Reduction of fetuin B in adaptation to pyramidal aerobic exercises and its role in modulating insulin resistance and serum aminotransferases in patients with type 2 diabetes

Fetuin B is one of the hepatokines associated with insulin resistance and liver function. The aim of this study was to investigate the effect of pyramidal aerobic exercises on insulin resistance and serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and fetuin B in patients with type 2 diabetes.

In this semi-experimental research, 60 patients with type 2 diabetes were selected by random sampling and randomly divided into two groups of exercise and control.The training protocol consisted of eight weeks of training, three sessions per week, and each session included 40-55 minutes of pyramidal aerobic training. The exercise was performed with 35-50%, 50-65%, and 65-80% of the resting heart rate (RHR), respectively. Fasting blood samples were collected 48 hours before and after the intervention. Dependent t-tests and covariance analysis were used for statistical analysis.

After the pyramid aerobic exercise period, a significant decrease was observed in the levels of insulin resistance, fetuin B, ALT, and AST compared to the control group (p<0.05).

Pyramidal aerobic exercises by reducing fetuin B have positive effects on reducing insulin resistance and improving liver disorders in patients with type 2 diabetes.