Aerobic Training and Curcumin can Improve Adiponectin Gene Expression in Adipose Tissue and Body Mass Index of Rats Fed with High-Fat Diet

Obesity has been recognized as a global problem that is increasing day by day. Although t

Obesity has been recognized as a global problem that is increasing day by day. Although the favorable effects of training and herbal supplements have been reported in this regard, the synergistic effects of the two are still a challenge for researchers. The purpose of this study was to investigate the effect of six weeks of Aerobic Training (AT) and Curcumin (Cu) consumption on adiponectin gene expression in the visceral adipose tissue and some anthropometric indicators of rats fed with High-Fat Diet (HFD).

In this experimental study, 40 rats with HFD (1.5 mg/kg/day high-fat emulsion) were randomly divided into five groups, including: (1) Healthy Control (HC), (2) High-Fat Diet Control (HFD), (3) HFD+Cu, (4) HFD+AT, and (5) HFD+Cu+AT. Aerobic training was carried out for six weeks, five sessions per week and each session of training was performed 10-50 minutes at a speed of 25-30 meters per minute and a slope of 15 degrees. Also, curcumin was fed to rats by gavage in the amount of 1.5 mg/kg/day. One-way analysis of variance with Tukey's post hoc test was used to analyze adiponectin and ANCOVA test with Bonferroni's test was used to analyze BMI. Data were analyzed in Prism GraphPad PRISM 3.8.3 software (P≤0.05).

Adiponectin gene expression levels in the HFD+AT, HFD+Cu and HFD+AT+Cu groups were significantly higher than the HFD group (P≥0.05). Weight and BMI levels in the HFD+AT and HFD+AT+Cu groups were significantly lower than the HFD (P≥0.05). Also, in the HFD+AT+Cu group, the weight and BMI levels were significantly lower and the adiponectin levels were significantly higher than the HFD+Cu group (P≥0.05).

It seems that exercise training and curcumin consumption both individually and synergistically can be effective in improving anthropometric characteristics by affecting adiponectin levels.he favorable effects of training and herbal supplements have been reported in this regard, the synergistic effects of the two are still a challenge for researchers.