Iranian specialists’ approach to treatment escalation in multiple sclerosis patients with cognitive impairment

Author(s):

Fereshteh Ghadiri , Elnaz Asadollahzadeh , Zahra Ebadi , Mohammad Ali Sahraian , Amirreza Azimi , Samira Navardi , Hora Heidari , Zohreh Abna , Marzieh Aboutorabi , Iman Adibi , Seyed Mohammad Baghbanian , Sepideh Paybast , Maryam Poursadeghfard , Samaneh Hosseini , Sareh Shahmohammadi , Mehran Ghaffari , Hamidreza Ghalyanchi-Langroodi , Masoud Ghiasian , Hoda Kamali , Ebrahim Kouchaki , Farzad Mehrabi , Ehsan Mohammadianinejad , Mohammad Ali Nahayati , Abdorreza Naser Moghadasi *

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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
People with multiple sclerosis ‎(MS) and their physicians recognize cognitive retention as an important desired outcome of disease-modifying therapies (DMTs). In this study, we attempted to gather the opinions of Iranian MS experts regarding the treatment approach toward clinical cases with different physical and cognitive conditions.
Methods
Opinions of 20 MS specialists regarding the best approach to 6 case scenarios (with different clinical, cognitive, and imaging characteristics) were gathered via a form.
Results
The estimated kappa of 0.16 [95% confidence interval (CI): 0.159-0.163; P < 0.001] suggested a poor degree of agreement on the treatment choice among the professionals.
Conclusion
Although most specialists agreed with treatment escalation in cases with cognitive impairment, there was no general agreement. Furthermore, there was not enough clinical evidence in the literature to develop consensus guidelines on the matter.
Keywords:

Cognitive Dysfunction , Multiple Sclerosis , treatment escalation , specialist , Iran

Language:
English
Published:
Current Journal of Neurology, Volume:22 Issue: 1, Winter 2023
Pages:
1 to 7
https://magiran.com/p2577163  
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