Design and in vitro evaluation of polyamidoamine polymer (PAMAM) based nanocarrier containing artesunate

In this study, a novel system of artesunate polymer based nanocarrier has been produced and characterized. The drug was grafted on the surface of the polyamidoamine dendrimer, then by cross-linking with ethylene glycol dimethyl acrylate, the polymer based nanocarrier was prepared. Then the prepared sample was analyzed by nuclear magnetic resonance spectroscopy (1HNMR), ultraviolet-visible spectrometer (UV-vis), and the scanning electron microscope (SEM). The results confirmed that the prepared nanocarrier has high water solubility, low density, the ability to load a large amount of drug, and sustained release. After pH dependent nanodrug degradation artesunate controlled released from the polymer network. According to the prolonged release time, the drug remains stable in the cellular environment. On the other hand, since drug release is pH dependent, by changing the pH in different environments, the amount of drug release can be controlled, this properties is one of the characteristics of targeted drug delivery, and effectively and significantly, the efficiency of this nanopolymer will be suitable for artesunate drug delivery.