The Effect of Aerobic Exercises and StragolTM Consumption on Serum AST, ALT and ALP Following a Myocardial Infarction in Male Wistar Rats

Stragol drops and Aerobic exercise may have additional positive effect on Liver hurt Indices after myocardial infarction. Thisstudy is aimed to analyze the effect of Aerobic exercises and stragol consumption on Serum AST, ALT and ALP following a Myocardial Infraction in male Wistar rats.

The present research was conducted experimentally. For this purpose, male Wistar rats were subjected to coronary artery occlusion surgery and then MI was confirmed by electrocardiography. 32 male rats aged 8-10 weeks were randomly divided into 4 groups (control, stragol, aerobic and combined exercise) and the aerobic exercise protocol for 6 weeks and 3 sessions every week was performed. The stragol group and the combined group received 9.58 microliters of straggle per day. Data were analyzed by one-way ANOVA test and Bonferroni test. The results have shown that the level of AST had a significant decrease in the groups of aerobic exercise (11.53 ± 0.206), consumption of straggle (11.56 ± 0.207) and the combined intervention (10.54 ± 0.217). The level of ALT also decreased significantly in the groups of aerobic exercise (20.405 ± 0.420), Stragal consumption (20.662 ± 0.419) and the combined intervention (18.669 ± 0.418). Meanwhile, the combined intervention had the greatest effect on reducing AST (10.54 ± 0.217) (P < 0.01). The Stragal consumption had no significant effect on the ALP level (227.747 ± 0.208). However, the ALP level decreased significantly in the aerobic training group (226.830 ± 0.207) and the combined intervention group (226.035 ± 0.209) (P < 0.01), while there was no significant difference between the effect of aerobic exercise and combined intervention (P < 0.01).

The research results show that all three interventions of aerobic training, consumption of Stragol and combined intervention have a significant effect on the level of AST and ALT and reduce the level of AST and ALT(P ≥ 0.05). This is while; combined intervention has the greatest effect on reducing AST (P < 0.01). Consumption of Stragal has no significant effect on ALP level. However, aerobic exercise and combined intervention significantly reduced ALP (P < 0.01), while there was no significant difference between the effect of aerobic exercise and combined intervention (P < 0.01).

Taking Stragol and performing aerobic exercises at the same time can have an effect on improving the condition of the liver tissue caused by MI due to the significant reduction of liver enzymes.