Efficient Synthesis of Thiazolo[4,5-d]pyrimidine derivatives without solvent

Author(s):

Mohsen Nikpour *

Message:
Article Type:
Research/Original Article (بدون رتبه معتبر)
Abstract:
4-Amino-5-bromo-2-substituted-aminopyrimidines were successfully reacted with various isothiocyanates in the alkaline alumina under Microwave irradiation to achieve a group of reported 2- aminothiazolo[4,5-d]pyrimidine derivatives . These compounds also carried out a multicomponent condensation with carbondisulfid and alkylhalides to furnish a group of reported 2- alkylsulfanylthiazolo[4,5-d]pyrimidine derivatives.
Keywords:

pyrimidine , thiazolo[4 , 5-d]pyrimidine , 5-Bromo-2 , 4-dichloro-6-methylpyrimidine , 4-Amino-5-bromo-2-substituted-aminopyrimidines

Language:
English
Published:
Journal of Chemical Reactivity and Synthesis, Volume:9 Issue: 3, Summer 2019
Pages:
1 to 8
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