The Short-term Effects of Aerobic Exercise and High-Fat Diet and Curcumin Extract on the Expression of Adiponectin and Interleukin Genes in Six Muscle Tissues in Male Wistar Rats

Adiponectin is a peptide hormone that is secreted from adipose tissue in humans and is effective on fat and glucose metabolism. Interleukin-6 also has the main role in various types of host defense mechanisms, including immune reactions and acute phase reactions. Therefore, the aim of the present study was to compare the short-term effects of aerobic exercise and high-fat diet and curcumin extract on the expression of adiponectin and interleukin genes in six muscle tissues of male Wistar rats. For this purpose, 50 two-month-old male rats were prepared and divided into five control groups, high-fat diet, curcumin and high-fat diet, exercise and high-fat diet, curcumin + exercise + high-fat diet. Data analysis was compared using one-way analysis of variance. The mean of intra-group differences was also compared using the one-way statistical test. The results showed that the average expression of the adiponectin gene of the subjects showed a significant difference among the 5 groups. The results of Bonferroni's post hoc test also showed a significant difference between the control group and other groups. Also, the expression of interleukin 6 gene increased in two groups - high-fat diet and high-fat + curcumin diet group compared to the control group. But in two groups of high-fat diet + exercise and high-fat diet + exercise + curcumin group, there was a significant decrease.