The effect of Eight Week Aerobic Training with Omega-3 Fatty Acids Supplementation on Paraoxonase and Myeloperoxidase Levels in Sedentary Women

The effectiveness mechanism of aerobic training and omega-3 fatty acids supplement alone or combined together is remarkably unknown. In the present study, the effect of eight weeks aerobic training with omega-3 fatty acids supplementation on the levels of paraoxonase and myeloperoxidase in the sedentary overweight and obese women have been investigated.

Forty sedentary young women with age ranging 25-40 years were randomly divided into four equal groups (10 subjects in each group) including placebo (P), omega-3 fatty acids supplement (O), aerobic training (T), and aerobic training + omega-3 fatty acids supplement (TO) groups. The subjects in the T and TO groups participated in aerobic training for eight weeks, three session per week, and the TO and O groups consumed omega-3 fatty acids supplement in daily 2000 mg dose. Blood samples collected before and after eight weeks intervention and the level of paraoxonase, myeloperoxidase and some other related metabolites was determined.

Serum levels of paraoxonase in the O, T and TO groups significantly increased compared to the P group (P < 0.001). Myeloperoxidase indicated a significant decrease in T and TO groups compared to P and O groups (P < 0.05). Moreover, significant increase of Apo-A1 and significant decrease of Apo-B were observed in both trained (T and TO) groups (P < 0.05).

Despite increasing the paraoxonase levels following omega-3 fatty acids supplementation, the supplementation in combination with the aerobic training did not exert synergistic effect in the studied variables compared to the aerobic training alone.