Investigating the effect of adaptogens on anxiety and stress ; a systematic review study

Adaptogens are a group of plants known for their innate ability to fortify the body's nervous system. They achieve this by influencing the hypothalamus-pituitary-adrenal axis, regulating cortisol secretion (stress hormone) and enhancing endorphin production. By bolstering the body's resilience against fatigue, adaptogens hold promise in improving the overall quality of life. However, it is imperative to substantiate their efficacy through rigorous scientific investigation, thereby fostering tranquility and enhancing societal well-being. Consequently, this study aims to examine the impact of utilizing plant adaptogens on three key phenomena: anxiety, stress, and fatigue.

The current study takes the form of a comprehensive systematic review, where an assortment of trials and studies were meticulously gathered using well-defined search terms. These were sourced from both internal and external databases, with a particular emphasis on article titles. The inclusion criteria encompassed articles published in either English or Farsi between the years 2000 to 2023. Moreover, the focus primarily revolved around the clinical trial aspect. Additionally, the articles selected for analysis were those that involved a combined intervention of chemical medicine. To aid in the screening and management of resources, EndNote version 7 software was employed diligently.

Out of the 2707 pertinent articles, a meticulous examination led to the inclusion of 27 fully qualified articles in this study. The comprehensive evidence substantiates the efficacy of botanical adaptogens in bolstering performance, enhancing the body's resilience against fatigue, and fostering mental well-being in the face of stress.

By affording appropriate opportunities for the utilization of these plants in the human diet or medicinal formulations, a significant stride is taken towards enhancing the collective mental well-being of society