Effect of High Intensity Interval Training on Adipose Tissue Levels of Piezo1 and Insulin Resistance Index in Diabetic Rats

Piezo1 is a mechanically sensitive caution channel associated with obesity and its related disorders such as insulin resistance. Purpose of this study was to investigate the effect of six weeks of high intensity interval training (HIIT) on Adipose Tissue Levels of Piezo1 mRNA and Insulin Resistance Index (HOMA-IR) in diabetic rats. For this purpose, 20 male wistar rat (10-12 weeks old, 370/25±13/76 gr) selected and type 2 diabetes induced by high fat diet and Streptozotocin. Then, the diabetic rats were randomly divided into experimental and control groups (n=10 in each). The rats in the experimental group participated in six weeks of high intensity interval training of running on treadmill at maximal velocity in exercise intervals for 40 seconds with 2 seconds of active rest interval between) 30 minutes per session and five sessions per week. All rats were dissected 48 hours after the last training session and the blood indices were evaluated using appropriate laboratory methods. The results of the present study showed that six weeks of HIIT resulted in significant increases in adipose tissue piezo-1 mRNA in addition to significant decreases in levels of insulin (P=0.000) and fasting blood glucose , HOMA-IR and body weight . Moreover, six weeks of HIIT lead to significant decreases in body weight . In general, it seems that in addition to improve body composition, six weeks of HIIT play a role in improving insulin resistance by increasing the levels of piezo-1