The Effect Of Combined Training On Aortic Atherosclerosis And FGF23 In Male Rats With Chronic Renal Failure

The aim of the present study was to investigate the effect of combined exercise on aortic atherosclerosis and FGF23 in male rats with chronic renal failure.

In this study, 20 male Wistar rats (mean weight 10 ± 250  g) were induced by NX5 / 6 method for chronic renal failure. After 2 weeks of recovery, they were randomly divided into two groups of control (n= 10) and combined training (n= 10) and performed a combined training protocol for 8 weeks. The combined training protocol consisted of two resistance training exercises on a ladder with 2 sets and 6 repetitions with percentages of body weight and aerobic exercise included 30 minutes of low-intensity treadmill activity.

The results showed that combined exercise reduced aortic atherosclerosis and decreased plaques, and FGF23 decreased significantly (p = 0.001). Parathoromon hormone also significantly decreased (p = 0.041) and calcium and phosphorus significantly decreased (p = 0.004 and p = 0.005, respectively).

Overall, the results showed that combined training could decrease FGF23, parathoromon hormone, calcium and phosphor on aortic atherosclerosis and cardiovascular disease indices in chronic renal failure patients.