Comparison of the Effect of Adding Ketamine to Sodium Thiopental and Propofol on the Quality of Sedation in Cataract Surgery with Phacoemulsification under Local Anesthesia and Intravenous Sedation

Due to the desired effects of combination therapy to provide lesser drug complication and better sedation quality during operation and the lack of any studies investigating the effects of Sodium thiopental and Propofol, in Combination with Ketamine During Phacoemulsification Cataract Surgery, we decided to do the present study.

In this randomized, double-blinded clinical trial, 60 candidates for elective cataract surgery were divided into two groups, A and B. Group A received sodium thiopental-ketamine, and group B received Propofol-ketamine. Sedation score, hemodynamic parameters of patients before, during, and after surgery, Side effects, and patients’ and surgeons’ satisfaction were recorded and analyzed by the anesthesiologist and compared in the two studied groups.

According to the statistical results, the surgeon's satisfaction was significantly higher in the group receiving thiopental sodium-ketamine. However, there was no significant difference in hemodynamic parameters in both groups during surgery and the recovery period. Heart rate and blood pressure in both groups first decreased and then increased. Also, there was no significant difference between the study groups regarding the sedation score during and after surgery. On the other hand, headache was seen in the two patients in the group receiving Propofol-ketamine. The patient's satisfaction was not significantly different in both groups, and demographic characteristics didn’t affect the results.

Based on current results, the thiopental sodium-ketamine combination is preferred to use during Phacoemulsification Cataract Surgery under topical anesthesia and intravenous sedation.