The Effect of 12 Weeks of Broccoli Supplementation with Combined Training on Plasma Hepatokines in Men with Type 2 Diabetes

Diabetes is one of the main causes of death in developing countries, which can be improved by various factors such as physical activity and proper diet. The purpose of this study was to investigate the effect of broccoli powder consumption along with combined training on some selected hepatokines in men with type 2 diabetes. This research was semi-experimental and practical type and was pre-test and post-test. For this purpose, 44 diabetic male volunteers were randomly divided into 4 groups of 11 people including control (placebo recipient), supplement (supplement recipient), exercise + placebo groups, and exercise + supplement. The training protocol included 45 minutes of resistance training with an intensity of 60-70% of one maximum repetition, 30 minutes of aerobic exercises (running) with an intensity of 60-70% of the maximum heart rate. Broccoli (supplement) was also prepared in powder form and 10 grams per day was given to each volunteer for 12 weeks. Blood samples were taken 48 hours before the first training session and 48 hours after the last training session and were used to analyze the indicators. Intergroup analysis of data was done using a two-way analysis of variance and a correlated t-test was used for intra-group differences. A significant difference between the groups was observed in ANGPTL3 and ANGPTL4 (P<0.001). Also, the examination of changes within the group showed that in supplementary, exercise, and supplementary exercise groups, a significant decrease was observed in ANGPTL3 and ANGPTL4 (p < 0.05). The results of the present study showed that 12 weeks of combined exercise along with broccoli supplementation improves selected hepatokines and insulin resistance. This improvement was greater in the group that exercised and took supplements at the same time.