The effect of an intense resistance training course on the serum levels of ammentin 1, cystatin C and fasting glucose in overweight and obese prediabetic men

Modulation of amentin 1 and cystatin C through exercise may be a potential therapy in the recovery of obese prediabetic subjects. The aim of this study was to investigate the effect of a selected high-intensity resistance training course on the serum levels of amantin 1, cystatin C and fasting glucose in overweight and obese prediabetic men.

In this semi-experimental study, 30 obese prediabetic men were randomly divided into two experimental and control groups (15 people in each group). The experimental group participated in an intense resistance program with an intensity of 80 to 85% of a maximum repetition for 8 weeks and three sessions each week for 60 minutes. Serum levels of amantin 1 and cystatin C and fasting glucose were measured on two occasions before and after the test. Data analysis was done using covariance analysis and correlated t at a significance level of P<0.05.

The values of cystatin-C (P=0.001), glucose (P=0.001), insulin (P=0.001), insulin resistance (P=0.001) decreased significantly in the experimental group, while the serum level Amentin-1 (P=0.001) had a significant increase. The paired t results also showed a significant increase in amantin-1, a significant decrease in cystatin-C and diabetes indicators in response to exercise (P<0.05).

Probably, intense resistance training can have a beneficial effect on the biomarkers of amentin 1, cystatin C and fasting glucose and some indicators of diabetes and body composition in pre-diabetic obese men.