Green synthesis of silver nanoparticle by the aqueous extract of Malva sylvestris L. and their effects of antibacterial activities

Since new evidence shows the anti-inflammatory effects of selenium, the aim of the present study was to conduct a systematic review and meta-analysis of clinical trial articles on the effect of selenium on serum C-reactive protein (CRP) levels in pregnant women.

In this study, Clinicaltrials.gov, ISI web of science, Cochrane Library, PubMed, and Scopus databases were searched until April 2024, and all randomized clinical trials that investigated the effect of selenium on serum CRP levels in pregnant women were selected. The DerSimonian and Laird random-effects model was used to calculate the overall effect size and heterogeneity. Cochran’s Q-test and I-squared tests were also used to assess statistical heterogeneity between studies.

The results of the meta-analysis conducted on the clinical trial studies showed that selenium supplementation reduced the serum CRP level by 3.99 mg/L, which was statistically significant (confidence interval (CI): -2.30, -5.6; 0.001˂P), and the heterogeneity between studies was also significant (0.001

The results showed that selenium supplementation can significantly reduce serum CRP levels in pregnant women. However, it seems that more studies in different parts of the world are still needed to confirm the beneficial effects or side effects of selenium supplementation on CRP levels among pregnant women due to the significant heterogeneity among studies.