A relation between hypothyroidism and membranous glomerulopathy

A 14 years old male patient referred to our clinic with generalized edema, weakness and faintness, which had initiated from 3 weeks ago. He had not any medical problems in his past history, only his father had history of hypothyroidism. In physical examination, he was pale and had ascite and lower extremities edema. His vital signs were normal. Renal biopsy was carried out and showed membranous nephropathy. The patient was treated with levothyroxin. By increasing of drug doses, proteinuria was gradually disappeared during 3 months and return to normal range completely. Therefore, we recommend that in all cases of nephrotic syndrome (massive proteinuria), thyroid function must be assessed and if the TSH level was higher than normal range, in the first step, levothyroxin is administerted for normalizing of thyroid function.