Prevalence of Methicilin-Resistance-Staphylococcus-Aureus in different wards of Imam Hossein Hospital in Tehran, in 2007-2008

Always Staphylococcus aureus is among the most frequent causes of morbidity and mortality worldwide. The unique ability of this organism to develop resistance to virtually any new antibacterial agent reflects the extraordinary capacity of this organism to adapt and survive in a great variety of environments. The purpose of this study is the detection of prevalence of Methicilin-Resistance-Staphylococcus-Aureus (MRSA) in Imam Hossein Hospital, in Tehran. This prevalence helps us to apply the best & correct antibiotic for this pathogen. For this cross sectional study‚ all samples of admitted patients (with a suspicion of infection), were evaluated from Nov. 2007 to Aug. 2008. Isolated staphylococci‚ tested for methicilin sensitivity by disc diffusion method (Methicilin disc). Of 6640 tested samples, 143 (2.1%) revealed to be positive for Staphylococcus aureus of whom 113(79%) were MRSA. Logistic regression showed a significant association between wards with prevalence of MRSA (p<0.028). The prevalence was more visible in Orthopedic, Neurologic Wards, and ICU. In this study there was no association between gender, sample type and age of patients with MRSA rate. In our study, prevalence of MRSA infection in Imam Hosein Hospital was 79%. Different Hospitals should identify prevalence of MRSA in different wards and declare causes of more prevalence in some wards then a coordinated program would lead to measures designed to reduce this incidence. The results highlight the need for effective implementation of infection control measures in the hospital. There is a need for the judicious use of antimicrobial agents in the hospital and outside as their indiscriminate use can exert pressure in selecting out MRSA and other multidrug resistant organisms.