Lipocalin-2: Response to a Progressive Treadmill Protocol in Obese and Normal-weight Men

Lipocalin-2 (Lcn2) a newer adipocyte-secreted acute phase protein was recently reported to be correlated with potential effects in obesity and inflammation. The reactions of this protein in progressive exercise have not yet been evaluated. This study was designed to compare the serum Lcn2 and high-sensitivity C-reactive protein (hs-CRP) levels after participating in an acute bout of treadmill protocol in obese and normal-weight men. Nine obese (aged: 43.2±4.6 yrs and body mass index (BMI): 31.4±1.6 kg/m2) and 9 normal-weight (aged: 42.9±4.4 yrs and BMI: 23.03±1.7 kg/m2; mean ± SD) sedentary men that have been selected randomly through volunteers, performed a single bout of exercise with a treadmill Bruce protocol. Before the exercise, Lcn2 level in obese was higher than normal-weight individuals (P<0.05). A significant increasing in Lcn2, hs-CRP, white blood cells (WBC) and insulin resistance index were observed after the exercise in two groups (P<0.05). The level of Lcn2, hs-CRP and WBC were, also, elevated in obese than normal-weight subjects after the exercise (P<0.05). It seems Lcn2 and other inflammatory markers were elevated in obese and normal-weight men after participating in one exhaustive progressive exercise. These changes in obese men were considerable.