Synthesis of Dithiocarbamate Ligands and Their Zn(II) Complexes and Studies of their Antibacterial Properties on the Eight Samples of Common Pathogenic Bacteria

The purpose of this research, is the preparation of Dithiocarbamate - Zn(II) Complexes and studies on their antibacterial properties in the different concentrations, against the pathogenic bacteria. A series of eight dithiocarbamate as sodium salts of formula R-NHCSSNa and LNa (where R is methyl-, ethyl-, propyl-, nonyland L is diphenyl-, piperidine- and morpholine) and piperazine-bis (dithiocarbamate) sodium salts were prepared by reaction between corresponding amine, CS2 and NaOH. Also, a series of eight complexes have been synthesized through reaction between each of the above eight dithiocarbamate ligands and Zn(NO3 2.6H2O. After the recognation of all compounds and test on their purity, all compounds were assayed for their antibacterial on the Eight Samples of Common Pathogenic Bacteria using, Paper Disk Diffusion method. Standard drugs such as Amoxicillin and Chloramphenicol were used for comparison purpose. Two variables as the length of hydrocarbon chain and the structure of the used amine in ligands and complexes caused different interactions toward microbes. Surveys on the complexes and comparision of their antibacterial properties showed their different effects on different types of bacteria which indicated the role of R groups in the structure. Comparison of the results with those of Amoxicillin and Chloramphenicol showed that the antibacterial activity of Zn dithiocarbamates complexes is better than the corresponding ligands. Among the tested Zn(II) dithiocarbamate complexes, Bis (nonyldithiocarbamato) zinc (II), Bis (piperidinedithiocarbamato) zinc (II) and Bis (morpholinedithiocarbamato) zinc (II) showed the most favorable antibacterial activity against E.coli, Y.entroculitica and P.mirabilis.