Anti-inflammatory Effect of Thymus kotschyanus Boiss. & Hohen. Extract on Rat's Hind Paw Edema Induced by Carrageenan

Advantages of herbal drugs have been known to human being for many years and they have been used for treatment of many diseases. Nowadays, inflammation is known to be one of the basic pathologic causes of the diseases. In this study the anti-inflammatory effects of Thymus kotschyanus Boiss & Hohen was investigated. Forty two Wistar rats were used into three divided groups. In the first group, extract of Thymus kotschyanus Boiss & Hohen in doses of 50,100,150,200 mg/kg was injected intra peritoneal and after one hour they were treated with hind paw edema test with carrageenan. In the second group, Indomethacin with the dose of 5 mg/kg was injected one hour before carrageenan and in the third one, saline was injected before carrageenan, every hours after carrageenan injection to rat’s right hind paw; the inflammation was separately measured by the change in the volume of mercury (plethysmometer). Indomethacin and Thymus kotschyanus Boiss & Hohen extract had significantly reduced edema in all five measurements (p