Comparing Different Brands of Omeprazole with Pantozole® in GERD Patients

Gastro-esophageal reflux disease (GERD), a chronic and relapsing condition with increasing prevalence, can affect quality of life very drastically (1, 2, 3, 4, 5, 6, 7) therefore different studies have been done to compare the effectiveness of each drug in comparison to the others and to determine the priority of each one to others regarding the efficacy and fewer side effects (15). In this study we aimed to make a comparison between Pantoprazol and different brands of omeprazol regarding their efficacy and meanwhile determine if different brands of omeprazole can have various effects on different cases.

In this clinical trial One-hundred GERD patients were studied to compare the effects of pantozole® and three different brands of omeprazole regarding their efficacy in treating GERD symptoms.

Among all cases 64.3% were female and mean age was 37.1 years (min: 16, max: 76, standard deviation: 15.0). 15.1%, 36.0%, 29.1% and 12.8% had BMI less than 20, 20-25, 25-30 and more than 30 consecutively. Both follow ups were successful in 73.5% while 14.2% had just one successful follow up and 12.2% were excluded from the study because they had no successful follow up after first visit. 25.5% were treated with A, 24.5% with B, 25.5% with C and 24.5% with D. Although the response rate in different drug groups showed various results, the differences were not statistically significant (all P values> 0.05). Sex and BMI category of patients had no significant effect on response rate between patients (all P values> 0.05).

According to our data, Pantozole®, Exiprazole®, Dr Abidi’s Omeprazole and Losec® have similar efficacy for control of GERD symptoms among Iranian patients with GERD.