The effect of hesperetin on serum level of aspartate and alanine amoinotransferase and hepatic and cardiac level of malondialdehyde in diabetic rats
Diabetes mellitus accompanies increasedmalondialdehyde as a marker of oxidative stress and increased serum level ofaspartate and alanine aminotranferase due to tissue damage. Due to antidiabeticeffect of hesperetin, this study was done to evaluate its effect on level of thesefactors in diabetes.
Male rats (n = 32) were divided into control, treatedcontrol, diabetic, and treated diabetic groups. For induction of diabetes,streptozotocin at a dose of 60 mg/kg (i.p) was injected. Hesperetin wasadministered at a dose of 10 mg/kg/day for 4 weeks one week post-experiment.Serum levels of aspartate and alanine aminotranferase were measured before thestudy and at the end of the study. In addition, level of malondialdehyde (MDA)was measured in liver and heart tissues.
A significant increase in serum level of aspartate and alanine aminotranferase (p<0.05-0.01) was observed in diabetic rats and hesperetin treatment significantly reduced only serum level of alanine aminotranferase (p<0.05). In addition, diabetes was followed by increased level of MDA in liver and heart tissues (p<0.01) and hesperetin treatment significantly reduced MDA level in these tissues (p<0.05).
Treatment with hesperetin could attenuate serum level of alanineaminotranferase and oxidative stress in hepatic and cardiac tissues, as indicatedby a lower tissue level of MDA.
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