Review on the Laboratory Diagnosis of Crimean-Congo Hemorrhagic Fever
Author(s):
Abstract:
Background
Crimean-Congo hemorrhagic fever (CCHF) is a potentially fatal zeonosis disease caused by a tick-borne virus from the Bunyaviridae family. The CCHF virus is transmitted to humans through the bite of the Ixodid ticks or contact with the blood or tissues of CCHF patients or infected livestock. Human infections begin with the nonspecific febrile symptoms, but progress to a serious hemorrhagic syndrome with a case fatality rate of 2-50%. As Rapid and precise diagnosis approach is critical for control, treatment and detection of patients and is useful for epidemiological studies.Materials And Methods
We conducted a review study on the different research works on diagnosis field in the world and Iran scientific databases, according to laboratory diagnosis of CCHFin bio safety, sampling and diagnosis assays aspects.Results
Laboratory Diagnosis of CCHF is based on three approaches: Virus Isolation, Serological assays (IIF, RPHA, and ELISA) and antigen detect assays (ELISA, RT-PCR, Real Time RT-PCR and Microarray)Conclusion
Early diagnosis is critical for patient therapy, prevention of potential nosocomial infections and in biological attacks. Also, the ability to distinguish between an infection with a reassortant and a non-reassortant variant may have prognostic value. According to Iranian health center facilities, we should design and established domestic methods in each three approaches especially in BSL4 facilities in Iran.Language:
Persian
Published:
Annals of Military and Health Sciences Research, Volume:9 Issue: 4, 2012
Page:
275
magiran.com/p942235
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!