The comparison between palatal connective tissue graft as a membrane with collagen membrane in combination with Bio-Oss and PRGF for the treatment of intrabony defects: (A Randomized Clinical Trial)

This randomized clinical trial was aimed at comparing the outcomes of palatal connective tissue+ Bio-Oss + PRGF versuscollagen membrane + Bio-Oss+ PRGFin the treatment of intrabny defects.

Fifteen patients affected by chronic periodontitis were enrolled. Each patient had at least two intrabonydefect (≥3mm). They were randomly assigned into two groups: patients treated i)with collagen membrane+PRGF+Bio-oss (control group) and ii) with palatal connective tissue as membrane + PRGF+Bio-Oss (experimental group). Clinical and intrasurgical examinations included probing depth(PD), clinical attachment level(CAL),gingival recession(GR),defect fill(DF), alveolar crest level(AC) and defect resolution(DR) were measured at baseline and after 6 months with re-entry surgery. Statistical analysis was performed usingTwo-way Repeated Measure ANOVA and Wilcoxon.

After 6 months, all of the evaluated clinical parameters showed statistically significant changes from baseline within each group (p< 0/05). The test group showed a significantly smaller amount of gingival recession as compared with control group.(0/8mm versus 1/7mm respectively; P<0/05) But there were not any statistically differences in other clinical parameters between the test and control groups(P>0/05): pocket depth reduction (3/7mm versus 3/5mm), clinical attachment gain (1/8mm versus 1/6mm), alveolar crest loss (1/8mm versus 1/7mm), defect fill(2/3mm versus 2/2mm) and defect resolution (4/1mm versus3/9mm).

According to the results obtained from this study it can be suggested that clinical effects of application of palatal connective tissue as a membrane and collagen membrane, in combination with Bio-Oss and PRGF in treatment of vertical bone defects, did not have any statistical significant differences except for gingival recession that was statistically smaller in connective tissue group.