Chronic Chlamydia pneumoniae infection and acute coronary syndrome

Various infectious agents like Helicobacter pylori and Chlamydia pneumoniae have been suggested for the development of atherosclerosis. The seroepidemiological association between Chlamydia pneumonia infection and coronary artery disease is still controversial. The purpose of this study is to investigate the association between anti-chlamydia pneumoniae antibodies(IgG and IgA) and acute coronary syndrome. 87 patients and 87 controls (matched by age and sex) were recruited into this case-control study from Febraury 2009 to January 2010. Sampling was done and anti-Chlamydia pneumoniae antibodies were measured using microimmunofluorescence method. Characteristics of population were recorded and statistical analysis was performed using SPSS software. The overall prevalence of anti-Chlamydia pneumoniae IgG and IgA were 43% and 10%,respectively.38 (43.7%) patinets and 38 (43.7%) controls were positive for IgG (OR=1). 8(9.2%) patients and 11 (12.6%) controls were positive for IgA (OR=0.69). There was no statistically significant difference between patients and controls in seropositivity of Chlamydia pneumoniae in uni- and multi-variate analysis. There is no association between Chlamydia pneumoniae seropositivity and acute coronary syndrome in this case-control study. More investigations are suggested because of controversial results.