Considering the heterogenicity of polycystic ovary syndrome (PCOS), the diagnosis is difficult. The aim of present study was to compare ovarian morphology, pattern of menstrual cycles and testosterone level in obese and non obese polycystic ovary syndromepatients. Clinical characteristics, hormonal profile and ovarian morphology were evaluated in 54 women with polycystic ovary syndrome, aged 21-48 years. They were devided in 2 groups regarding Body Mass Index; obese (BMI ≥ 25) and nonobese (BMI < 25). Fidings were statistically analyzed. Mean BMI was 28.5 ± 3.2 in obese group and 21 ± 2.6 kg/m2 in nonobese group. Menstrual cycles were regular in 11 patients (20.4%) and irregular in 43 patients (79.6%). BMI was 23.6 ± 3.6 in patients with regular cycles and 25 ± 5 in those with irregular cycles (P = 0.36). Mean testosterone level was 7.1 ± 1.7 in obese and 5.6 ± 2.9 ng/ml in nonobese group (P = 0.69). In obese group, ovarian morphology was normal in only 8 patients (29.6%) and abnormal in 19 patients (70.4%) (P = 0.039) and in nonobese group 12 patients (44.4%) had normal morphology and 15 patients (55/6%) had abnormal morphology. (P = 0.039). Our study suggests that there is significant correlation between BMI and ovarian morphology but there is no significant difference between BMI and menstrual cycle or BMI and testosterone level. Thus both obese and nonobse PCOS patients show different presentations and it is necessary to do more studies to compare clinical features of PCOS in obese and nonobese patients for early diagnosis and management.

Since little research, in Iran, has been carried out into the relationship between implicit and explicit memories and linguistic issues, the present research seeks to study the information-processing trend with regard to the vocabulary related to food, body style, and body organs in ordinary and obese female subjects. To achieve such a goal, ten women suffering from severe obesity, ten obese, and ten normal women were studied using implicit/explicit memory tasks. In memory tasks, the vocabulary related to food, body style, and body organs was used. The results showed bias in regards to the implicit memory. The subjects with severe obesity were more successful in completing word stems related to food. The obese women performed better on the vocabulary related to food and body style. Showing the same bias to different types of words, the normal group displayed no special tendency. The explicit memory task revealed no bias in any certain group.

The effective method of treatment of Polycystic Overy Syndrome (PCOS) is lifestyle modification. The aim of this study was to evaluate the effect of 12 weeks aerobic exercise on DHEAso4, 17OH-Progestron Concentrations, number of follicles and menstrual condition of women with PCOS. In this clinical trial, 40 PCOS patients lean (BMI<20) and obese (BMI>25) randomly divided into two trained and sedentary control groups. DHEAso4, 17OH-Progestron Concentrations, number of follicles and menstrual condition were measured before and after the program (12-week exercise training program, aerobic exercise at 60-80% of maximal heart rate, 25-30 min/day, 3 days/week). Decline of DHEAso4, 17OH-Progestron Concentrations were significant after exercise in obese group (P=0.023, P<0.0001). The number of follicles right and left ovaries decreased significantly after exercise in two groups lean and obese (Right; P=0.019, P=0.041 and Left ovary; P=0.005, P=0.008). Menstrual situation was improved after exercise in obese and lean groups (P=0.028, P<0.0001). The body weight decreased significantly after exercise in obese groups (P<0.0001). It seems that a term of exercise with weight loss can induce decline of DHEAso4 and 17OH-Progestron. In addition, exercise lead to improved menstrual condition and reduction of number of ovarian follicles per groups of lean and obese.

The effective method of Polycystic Ovary Syndrome treatment is lifestyle modification. The aim of this study was to determine the effect of a twelve-week aerobic exercise on Ovarian Androgens and Body Composition of women with Polycystic Ovary Syndrome. In this clinical trial، 20 obese patients (BMI>25 kg/m2) and 20 lean patients (BMI<20 kg/m2) with Polycystic Ovary Syndrome were selected. Lean and obese patients were randomly divided into intervention and control groups. The intervention group participated in a 12 week، 3 sessions per week with intensity 65-80% of maximal heart rate for 25 - 30 minutes of aerobic exercise، while this intervention was not performed in the control group. BMI، WHR، LH، FSH، prolactin and iestosterone hormones were measured before and after the intervention. The data were analyzed using the Paired and independent T tests. BMI decreased significantly after exercise in obese group (P<0. 0001). The reduction of prolactin was not significant after exercise in both lean and obese groups (P>0. 05). LH/FSH significantly decreased after exercise in the lean group (P=0. 049). The testosterone concentration was significantly decreased after exercise in both lean and obese groups (P<0. 05). A period of exercise with body weight loss and reduction of BMI can contribute to the decline of testosterone concentration، decrease of LH/FSH ratio، improvement of metabolic condition. It prevents the increasing of prolactin and also the side effects of hyperandrogenism.

The aim of the present study was to describe the clinical and laboratory findings among a series of patients with non-alcoholic steatohepatitis (NASH). The clinical, biochemical features of 26 patients with non-alcoholic steatohepatitis, observed for 4 to 44 mo (mean 15.2 mo) were analyzed. Eleven of the patients (42.3%) were women and the rest were men (57.7%). Mean age was 40.12  11.4 (range 17-67). Two of the 4 obese patients (BMI 30) were men (15.4%) and the only morbid obese patient (BMI 40) was a women. Totally thirteen patients were over weight (40 BMI<30) 6 of whom were women. Thirteen patients (6 men and 7 women) had BMI within the range of 25 to 30. Eight patients (6 men and 2 women) had normal weight. Twelve patients (46.2%) had hyperlipidemia, while only 2 had the past consumption history of drug-induced NASH (7.7%). Initially 10 patients were asymptomatic, another 10 had non-specific symptoms (totally 80.8%) and 5 patients had the symptoms related to NASH. Only 1 patient progressed to cirrhosis and 5 showed fibrosis in their liver biopsy. The finding of this study suggests that non-alcoholic steatohepatitis can be a progressive liver disease. Furthermore, it suggests that this disease should not be considered a disease predominantly seen in an obese women with diabetes mellitus.

difficult diagnosis in endocrinology, gynecology, and reproductive medicine. To help solve this issue, the Rotterdam consensus conference proposed to include the ultrasonographic follicle count as a new diagnostic criterion, in addition to hyperandrogenism and oligo-anovulation. Unfortunately, its assessment does not offer sufficient reliability worldwide. To explore the possible roles of altered circulating androgens and anti-mullerian hormone among PCOS women regarding their body mass index and their outcomes after IVF. In this preliminary prospective study, 195 women with PCO were included, they were divided according to their body mass index (BMI <27 kg/m2) as obese PCOS (n=91) and overweight PCOS (BMI ≥27 kg/m2) (n=104). Serum levels of androgens (dehydroepiandrosterone sulfate [DHEAS], testosterone and androstenedione [A4]), and anti-mullerian hormone [AMH]) were assessed and compared with the endocrine profile and cycles outcomes. AMH, A4, FSH, and TSH, concentrations and were significantly higher in obese than in overweight women (p˂0.001). Contrary, LH: FSH ratio values, E2, PRL and DAHE-S levels were significantly lower in obese than in overweight women (p˂0.0001). Total oocyte retrieved, mature and fertilized oocyte were significantly higher in obese than in overweight women. Among pregnant obese PCOS women both AMH and A4 were significantly increased and DAHE-S was significant decreased compared to pregnant overweight PCOS women. Obese PCOS women have a higher chance of getting pregnant over those categorized as overweight PCOS. Also, androgens and AMH levels recommended to be considered in IVF attributes among obese and overweight PCOS women.

Interleukin 10 (IL-10) is an anti-inflammatory cytokine that its levels decrease in the presence of obesity and related diseases. Due to the lack of sufficient studies in this regard on healthy or patient obese women; this study was performed with aim to determine the effect of short term aerobic training on serum IL-10 in obese women.
This study was performed in summer 2016 on 30 sedentary middle-aged obese females aged 30-40 years (30≤BMI≤36 kg/m2) in Tehran, Iran. Subjects were divided into experimental (n=15) and control (n=15) groups. Experimental group underwent an aerobic training program for 6 weeks, 3 sessions per week with 30-45 minutes at 60 to 75% of the heart rate max. Abdominal obesity and other anthropometrical markers. as well serum IL-10 were measured at 48 hours before and after exercise intervention. Data were analyzed by SPSS software (version 15) and independent-t and dependent-t tests. P Significant increase were observed in body weight, BMI, body fat percentage and abdominal obesity in experimental group (p Short term aerobic training with moderate to high intensity leads to decreased obesity determinative indexes and increased serum IL-10 in obese females.

According to various studies, obese women, have an increased risk of a number of pregnancy complications and adverse pregnancy outcomes. Worryingly, the prevalence of obesity is rising during pregnancy. The present study was done to determine the incidence of obesity and its relationship to pregnancy complications. In this prospective study, all pregnant women in their early stage were referred to women’s clinic of Fatemiyeh Hospital by all health care centers and private clinics as soon as diagnosed. Obesity was defined as having a body mass index (BMI) of ≥30 kg/m² or more. So, pregnant women were divided into obese and non-obese cases according to BMI. All the women had no previous systematic diseases and received routine prenatal care until their labor. Demographic and pregnancy data were obtained on arrival and were recorded in special files; and the cases’ economic status was determined by means of a special checklist. The obtained data was analysed by means of non-parametric variance analysis of, chi-square, Fisher exact t- test, Mann Whitney U, linear regression, and correlation co-efficient; and P≤0.05 was taken as the significant level. Totally 1194 pregnant women were studied. Prevalence of obesity was %13 (162 pregnant women). Obese women were older and had more childbirth. According to variance analysis and confounding factors including age and parity, obesity was found to be an independent factor in the occurrence of pre-eclampsia (P<0.001), gestational hypertension (P<0.01) and hydramnios (P<0.001) as well. Cesarean rate in obese women was greater and significant (P<0.001). Results confirmed that despite appropriate prenatal care, obesity was associated with an increase in pregnancy complications. So in order to improve the quality of care, pre-conceptual care is recommended. Weight losing, as an easy and inexpensive procedure in women who refer to the health centers to receive health care and family planning service, is essential and is recommended.

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder among women of the reproductive age.The complications of this syndrome such as Hyperandrogenism, infertility, Hirsutism and pregnancy complications increase in obese women with PCOS. This study aimed to compare the clinical and laboratory features of overweight and obese women suffering PCOS with women of normal weight. In this cross-sectional study, 368 PCOS patients were studied. According to the Rotterdam Criteria, they were divided into two groups of equal body mass index (BMI) ≥25 and <25. They were compared in terms of age, parity, infertility history, menstrual disorders, family history of diabetes, weight, BMI, waist to hip ratio (WHR), systolic and diastolic blood pressure and clinical and laboratory symptoms of PCOS. In both groups, the common phenotype was IM/ HA/PCO and the frequent menstrual pattern was Oligomenorrhea (81.2%). In group the overweight and obese group and the normal-weight group, respectively, the mean age was 26.84±5.28 and 25.59±4.66 (p=0.0001), the mean systolic blood pressure was 114.4±11.61 and 106.66±10.02 (p=0.01), the mean diastolic blood pressure was 73.24±8.97 and 67.29±8.36 (p=0.01), infertility was 45.5 % and 22.61% (p=0.0001) and the android obesity incidence was higher in the patients than normal individuals (p=0.0001). Infertility, android obesity and increased systolic and diastolic blood pressure was higher in the overweight and obses group than the normal weight group. Therefore, a follow-up for these patients in order to prevent the complications seems necessary.