Yogurt is a fermented dairy product, which is a popular product throughout the world and has positive effects on public health, due to its nutritional properties. Aloe vera extract is a kind of vegetable derivative, which has high nutritional value and antibacterial properties. In this research the effects of Aloe vera extract (0.5, 1, 1.5, 2% w/w) addition on the textural (syneresis), chemical (pH, acidity), viability of yoghurt probiotic microorganisms, yeast and mold, antioxidant properties and sensorial attributes of stirred probiotic yogurts were investigated during the shelf life (1st, 7th, 14th and 21thday of production). The results showed addition of Aloe vera extract decreased the pH value and increased acidity but decreased syneresis. Bifidobacterium and Lactobacillus viability increased with Aloe Vera extract addition but yeast and mold counts decreased. The addition of Aloe vera extract increased antioxidant properties of yoghurt. Sensorial analysis indicated that panelists preferred yogurt samples with low Aloe vera extract rates. However, higher rates of Aloe vera extract affected the flavor and overall acceptability and lowered their panelist scores. During time, pH decreased and acidity and syneresis increased. Overall, it was concluded that the best treatment from all aspects, was 0.5% Aloe vera extract.

The aim of this study was to determine the effects of six weeks of endurance training and aloe vera consumption on COX-2 and MMP-9 levels in mice with breast cancer.
This is an experimental study. 35 BALB/c mice were randomly divided into 5 groups: control (healthy), control (cancer), training (cancer), aloe vera (cancer) and aloe vera training (cancer). Induction of breast cancer tumors were done in mice by implantation method. The training groups performed a swimming endurance training for 6 weeks, Aloe Vera group consumed Aloe Vera for 6 weeks to the amount of 300 mg/kg of body weight via intraperiotoneal injection and the control group were kept in cages for 6 weeks. Sampling was performed 48 hours after the last training session. To determine the changes between the groups, one way ANOVA was used and if the changes were meaningful the Tukey's test was used.
The data analysis showed that six weeks consumption of Aloe Vera extract made a significant decrease in the level of cyclooxygenase-2 in mice with breast cancer. Also, a significant reduction in the amount of extract group (Cancer) compared to the controls (cancer) was observed. There was found a meaningful decrease on the matrixmetalloproteinase values in the endurance group and consumer groups of Aloe Vera extract in mice with breast cancer after 6 weeks of training. In addition, significant reduction in Matrix metalloproteinase levels in the training group (cancer) and extract group (Cancer) compared to the controls (cancer) was observed.
The results of the present study showed that the induction of the cancerous tissue into the mice caused increased levels of COX-2 and MMP-9 values. This increasing is the early symptoms of breast cancer. It also seems that endurance training and Alovera extract can reduce the levels of COX-2 and MMP-9.

The Aloe vera plant of the Liliaceae family is a known medicinal plant and contains compounds that play an important role in the improvement of inflammatory diseases. On the other hand, exercise plays an important role in the rehabilitation of cancer patients. The aim of this study was to investigate the effect of Aloe vera extract and swimming exercise on serum levels of epidermal growth receptors in mice with breast cancer.
The experiment was implemented for six weeks. Thirty-five mice were randomly divided into five groups: 1- healthy control, 2 - control (cancerous), 3 - exercise (cancerous), 4 - aloe vera (cancerous) and 5-practice extract (cancerous) groups. Aloe vera extract at 300 mg/kgBW/day, was given to the mice. The workout time for the first day was 10 minutes, increasing by five minutes to 60 minutes daily. At the end, serum levels of epidermal growth receptors were measured by the ELISA method.
Consumption of Aloe vera extract had a significant effect on levels of HER2 (P=0.017) but did not have a significant effect on EGFR (P=0.576). Endurance swimming training had a significant effect on levels of HER2 (P=0.002), but had no significant effect on EGFR (P=0.769). Also, the use of Aloe vera extract with endurance training had a significant effect on HER-2 level (P=0.002), but there was no significant effect on the EGFR (P=0.558).
It is possible that Aloe Vera extract and swimming exercise has beneficial effect on the improvement of breast cancer by reducing the excessive expression of HER2 and pro-inflammatory cytokines.

Diabetes disease can have destructive effects on different organs such as the liver. At this situation, alanine aminotransferase and aspartate aminotransferase increase in the blood. This study aimed to review the effect of aloe vera with swimming training on alanine aminotransferase and aspartate aminotransferase levels of streptozotocin induced diabetic rats.
84 rats divided into seven groups; -week healthy control, fourth-week healthy control, first-week diabetic control, fourth-week diabetic control, Aloe Vera extract, swimming training, and swimming training with Aloe Vera extract. The training program included 30 minutes of swimming, three times per week, for 4 weeks. At the end, alanine aminotransferase and aspartate aminotransferase levels were measured by gathering blood samples from the heart. One-way ANOVA and Tukey post hoc tests were used for statistical analysis of data (α = 0.05).
The results showed that induction of diabetes significantly increases alanine aminotransferase and aspartate aminotransferase (p= 0.001) Also swimming training and Aloe Vera consumption for four weeks have significant effect on reduction of alanine aminotransferase and aspartate aminotransferase (p= 0.001), whereas the four-week swimming training together with Aloe Vera consumption has more effect on the reduction of alanine aminotransferase and aspartate aminotransferase (p=0.001).
It can be concluded that although swimming training and Aloe Vera consumption separately have lowering effect on alanine aminotransferase and aspartate aminotransferase, but swimming training together with Aloe Vera consumption has more effect on the reduction of alanine aminotransferase and aspartate aminotransferase.

The adipocytokine visfatin is secreted by the adipose tissue and is associated with plasma glucose level and can affect diabetes. Furthermore, aloe vera is used in traditional medicine as an anti-diabetic drug. The current study aimed to determine the effects of swimming along with taking aloe vera extract on visfatin serum level, glucose level, and the ratio of triglycerides to high-density lipoproteins in diabetic male rats.
In this experimental study, 28 diabetic male rats were chosen and placed in four groups of 1) control, 2) swimming, 3) aloe vera extract and 4) swimming along with aloe vera. The swimming program began with 6 minutes in the first week and increased to 36 minutes in the sixth week. Groups 3 and 4 received 300 mg/kg of aloe vera extract per day. Control group didn’t performe any regular exercise and also didn’t receive any extract. Data were analyzed by using ANOVA and the Tukey post hoc test.
In all the three groups (swimming group, extract group and swimming along with extract group), there was a significant reduction in blood glucose, ratio of triglycerides to high density lipoproteins and the visfatin level compared to the control group (p≤0.05).
Results indicated that swimming together with aloe vera extract reduce the ratio of triglycerides to high density lipoproteins and glucose and increase visfatin receptor's sensitivity, and thus reduce visfatin serum levels in diabetic male rats.

Studies show that there are relations between various types of stress and liver function. The main aim of this study was to determine the effects of immobilization stress and Aloe vera extract on serum level of Serum Glutamic Pyruvic Transaminase (SGPT) and Serum Glutamic Oxaloacetic Transaminase (SGOT) in male rats. In this laboratory experimental study، male Wistar rats were randomly divided into control، Aloe vera extract or normal saline receiving، under acute or chronic immobilization animals of 5 in each group. After 6 weeks blood samples were collected using cardiac puncture method. Following serum collection، SGOT or SGPT level was measured by spectrophotometry method. Data were statistically analyzed and compared between groups using ANOVA. Serum SGOT level was significantly increased in rats enduring acute or chronic immobilization animals compared with control rats (p<0. 01 and p<0. 001، respectively). Serum level of SGOT level was significantly increased (p<0. 01) and of SGPT was significantly decreased (P<0. 01) in extract receiving animals compared with control rats (p<0. 001). Our findings indicate that immobilization and Aloe vera extract is serum SGOT enhancer. In this respect، in clinical considerations، pathological effects of immobilization or Aloe vera intake is important in the field of SGOT biochemical alteration.

Breast fissure is a common problem in lactating mothers, which causes early discontinuation of breastfeeding. This study was performed to compare olive oil with aloe vera extract and breast milk on pain severity and breast fissure in lactating mothers.
In this clinical trial, 90 lactating mothers with breast fissure in Gonabad city (2015), were divided into three groups of 30 subjects using random allocation. In the first group, mothers rubbed 0.5ml of olive oil and in the second group 0.5ml of Aloe vera extract and 3-4 drops of their milk on nipple and areola 3 times a day, after each breastfeeding. The third group rubbed 3-4 drops of milk on the nipple and areola after each breastfeeding. The visual analog scale (for determining pain severity) and store scale (for determining intensity of breast fissure), were completed at the first day (before intervention), the third day (during intervention), and the seventh day (end of intervention). Data were analyzed using one-way ANOVA and Kruskal-Wallis tests.
At the end of the intervention, there was significant differences among the three groups in terms of the pain severity and breast fissure, so that pain severity and breast fissure was least in the group received aloe vera extract. There was no significant difference between breast milk and olive oil groups.
The findings of this study revealed that olive oil, Aloe vera extract, and breast milk reduce pain severity and breast fissure in lactating mothers, but aloe vera extract is more effective than olive oil and breast milk.

Aloe vera (Aloe barbadensis) and Teucrium (Teucrium polium) are used in traditional medicine as anti-diabetic herbs. The present study examined the effects of TP and aloe vera extracts on some metabolites like glucose، total cholesterol، LDL، HDL، VLDL and triglycerides in streptozotocin-induced diabetic Wistar rats. In this experimental research، forty rats were randomly divided into five equal groups. Trials in the study included the control group، diabetics (50 mg/kg STZ)، diabetics+extract of Aloe vera (300mg/kg)، diabetics+Teucrium (300mg/kg)، and diabetics+glibenclamide (5mg/kg). All solutions were given orally for 14 days. Blood samples of the rats were derived from their hearts on the 15th day of the experiment and their serum was isolated. Blood glucose in diabetic rats significantly reduced by aloe vera and Teucrium extracts (P≤0. 05). It was found that concentration of total cholesterol، HDL، VLDL and triglycerides in rats receiving Aloe vera and Teucrium extracts and glibenclamide was significantly lower than diabetic rats (P≤0. 05). Aloe vera and Teucrium were more effective than glibenclamide in reducing blood cholesterol levels. Compared with Aloe vera and glibenclamidettreatment with Teucrium had less effect on serum triglycerides. Serum insulin levels in diabetic animals receiving the herbs extracts significantly increased in comparison with diabetic rats. The use of Aloe vera and Teucrium extracts improve insulin secretion and reduce blood glucose and LDL

Medical treatment of tooth decay is associated with the possibility of allergic reactions and increased bacterial resistance to antibiotics. This study aimed to evaluate the phenolic compounds and antimicrobial effects of the hydroalcoholic extracts of Aloe vera and Glycyrrhiza glabra against four cariogenic bacteria in vitro.
In this empirical study, hydroalcoholic extracts of Aloe vera and Glycyrrhiza glabra were obtained using the percolation method. Then preparing standard strains of Streptococcus mutans, Streptococcus salivarius, Streptococcus sanguinis, Actinomyces viscosus. Antibacterial activity of extracts were determined by micro broth dilution method. Concentration of phenolic compounds, flavonols and flavonoid were determined using the optical density (OD) method.
FINDINGS: In this study, total phenolic content and concentrations of flavonols and flavonoids were 3, 37 and 10 mg/g in the Aloe vera extract, respectively, while they were 36, 78 and 14 mg/g, respectively in the extract of Glycyrrhiza glabra. Regarding the frequency of cariogenic bacteria, MIC and MBC of the Glycyrrhiza glabra extract for Streptococcus mutans were 0.5 and 1 mg/ml, respectively, while they were 0.25 and 0.5 mg/ml for Streptococcus salivarius, 0.125 and 0.5 mg/ml for Streptococcus sanguinis, and 0.25 and 0.5 mg/ml for Actinomyces viscosus, respectively. Moreover, MIC and MBC of the Aloe vera extract were 4 and 16 mg/ml for Streptococcus mutans, 0.5 and 2 mg/ml for Streptococcus salivarius, 1 and 4 mg/ml for Streptococcus sanguinis, and 1 and 2 mg/ml for Actinomyces viscosus, respectively. MIC and MBC of Aloe Vera extract (4 and 16 mg/ml) was significantly higher than the Glycyrrhiza glabra extract (0.5 and 1 mg / ml) (p According to the results of this study, the hydroalcoholic extract of Glycyrrhiza glabra exerted greater antibacterial effects against the studied bacteria compared to the Aloe vera extract due to the higher concentration of phenolic compounds. In addition, Streptococcus mutans showed higher resistance against the herbal extracts compared to the other bacteria

Herbs have a long history in treating diseases and are usually side effect free. The Aloe vera plant is well known in wound healing in human skin. This study was carried out to evaluate the healing effect of Aloe vera on experimentally wounded Mugil cephalus. For this purpose, four aquaria, each containing six wounded M.cephalus weighting 110±30g were prepared. Fish were anesthetized with clove oil (150 mg/L) and then skin wounds with 5 mm diameter and full thickness and circular shape were created by surgical punch on the left side of each fish biopsy. Aloe vera extract with different concentrations (0.1, 1,2 g/L ) was two times a week in three aquaria and one aquarium was used as a control treatment. Tissue samples were taken from the skin wounds at day 21 after wounding fish fixed in 10% formalin and then processed through routine histological methods. The results showed that fish wounds in the concentration 0.1 g/l Aloe vera were cured after three weeks (P