مجله دیابت و متابولیسم ایران
سال بیست و یکم شماره 3 (پیاپی 100، امرداد و شهریور 1400)

One consequence of diabetes mellitus is increased inflammation, which is exacerbated by training. The objective of this study was to evaluate the effect of eight weeks of aerobic moderate-intensity continuous training on Interleukin-1 beta, Interleukin-13 responses in male Wistar diabetic rats.

36 diabetic rats were randomly assigned into 3 equal groups (control (C), diabetic (D), and diabetes + training (D + T)), and subjected to eight weeks of aerobic moderate- intensity continuous training intensity at the first: the10 min on 10m/min and at the final: 55min on 26m/min speed. Interleukin-1 and interleukin-13 were measured in soleus muscle tissue to examine the pro-inflammatory and anti-inflammatory indicators. ANOVA and Scheffe post hoc tests were used for data analysis.

Induction of diabetes caused a significant increase in IL-1β and IL-13 (P<0.001) and continuous exercise intervention also significantly reduced IL-1β levels in diabetic rats (P = 0.02). However, there was no significant change in IL-13 in D + T group compared to D group (P = 0.985).

According to the results of this study, the effect of aerobic exercise is probably a positive effect on reducing the pro-inflammatory index of IL-1β and no effect on the anti-inflammatory index of IL-13 in diabetic rats. However, definitive confirmation of these results requires further research in this area.

Imbalanced production of adipokines as leptin and adiponectin in diabetic patients may lead to the development of metabolic complications. Therefore, the aim of this study was to determine the effects of 2-month of caffeine ingestion along with aerobic training on changes in serum leptin and adiponectin levels and leptin/adiponectin ratio (LAR) in type 2 diabetic men.

Thirty-two diabetic men participated in a quasi-experimental designs in the four groups for two-months period of a aerobic training (treadmill walking 3 times/week, 1.5 hour/session, 65-85% HRR) with and without caffeine ingestion (3 mg.kg-1.day). Serum changes in leptin and adiponectin were measured during two phases (baseline and 24-hours after completing of the training program). Data were analyzed by one-way ANOVA and bonferroni's post-hoc test at level P≤0.05.

Administration of two-months caffeine (CA) alone and combination with aerobic training (AT) were significantly could reduced and increased in leptin and adiponectin level, respectively (P=0.001). Thus, the combined group (AT+CA) effect were far more appropriate intervention in changing the studied indices (P=0.001). Also, the LAR method was notable reduced in all study groups, although these effects were more significantly in the combined group (AT+CA) (P=0.001).

It seems administration of caffeine supplementation and aerobic training for two-months have a positive effects on the improved relative of leptin and adiponectin levels as well as their ratio in diabetics, although the combination of these two variables has been shown to have far more dual effects.

Today, in most hospitals in Iran, there is an extensive database of patient characteristics that includes a large amount of information related to medical, family and medical records. Finding a knowledge model of this information can help to predict the performance of the medical system and improve educational processes.

Data mining techniques are analytical tools that are used to extract meaningful knowledge from a large data set. In this study, the information of 500 people referred to Shahid Bolandian Health Center in Qazvin has been used. In this research, a predicted model has been performed using decision tree data mining methods and neural network and Bayesian network.

The decision tree model has the highest accuracy and the Bayesian network has the lowest accuracy in diagnosing diabetic patients, and consequently the decision tree has the least error and the Bayesian network has the highest error. The decision tree model with 95.68% had the highest accuracy in prediction.

Fat has the greatest effect in predicting diabetes and gender has the least effect in predicting diabetes. Based on the decision tree analysis, the rules obtained among the stated characteristics of age and sugar variables have the greatest effect in predicting the occurrence of diabetes (according to software analysis) and by creating a proper diet can prevent this disease Prevented.

Exercise and the simultaneous use of progenitor cells is a new strategy aimed for reducing diabetic disorders. One of the known mechanisms is angiogenic disorders caused by diabetes. Therefore, the present study was performed to determine the simultaneous effect of resistance training with endothelial progenitor cell injection on the expression of angiogenic factors in the skeletal muscle of diabetic rats.

In this study, 30 rats were randomly divided into 5 groups: healthy, diabetic control (D) trained diabetic (DR), diabetic with endothelial progenitor cell injection (DI), diabetic trained with endothelial progenitor cell injection (DRI) were divided. VEGF protein expression was measured by Western blotting and insulin resistance index was measured by ELISA. The data were analyzed using two-factor analysis of variance test with SPSS software version 19 at a significance level of 5%.

In this study, 6 weeks of resistance training or progenitor cell injection caused a significant increase in VEGF and a significant decrease in insulin resistance index in diabetic rats. In the group that used simultaneous exercise and injection compared to the group with exercise and injection and these changes were significant in the group of simultaneous use of exercise and injection compared to the group of exercise with injection.

Based on the results of this study, it can be stated that resistance training or injection of endothelial progenitor cells can stimulate angiogenesis in skeletal muscle, also the simultaneous use of these two factors is a better way to increase angiogenesis in rats

Diabetes disorders can lead to muscular burnout. The aim of this study was to determine the simultaneous effect of resistance training and endothelial stem cell injection on the factor of degeneration in the muscles of diabetic rats.

36 male wistar rats (age 6 weeks with weight of 20±200g) were randomly divided into five groups of basic healthy, diabetic control (D), diabetic and resistance training (DR), untrained diabetic by injection of endothelial stem cells (DI), diabetic training by simultaneous injection of endothelial stem questions (DRI). Western blotting and insulin resistance index were measured by ELISA method to evaluate the changes in MURF1 expression. The data were analyzed by two-factor analysis of variance by SPSS software version 19 at a significant level of α≥%5.

In this study, 6 weeks of resistance training significantly reduced MURF1 and insulin resistance index. The interactive effect of resistance training and stem cell injection also resulted in a significant decrease in murf1 levels, but insulin resistance index was not significantly superior to only training or injection.

Based on the findings of this study, it can be stated that resistance training or injection of endothelial ancestral cells can improve muscular degeneration, but simultaneous use of these two strategies was not superior in reducing atrophy complications in diabetic rats.

People with diabetes face psychological challenges. Therefore, it is important to pay attention to cognitive therapies based on mindfulness in this field. The aim of this study was to evaluate the effectiveness of mindfulness-based cognitive therapy on anxiety tolerance and cognitive flexibility in patients with type 2 diabetes.

The research method was quasi-experimental with pre-test-post-test design with a control group. The statistical population of the present study was all type 2 diabetic patients referred to the Maternal Diabetes Center, Touba Specialized and Sub-Specialized Clinic and Mostafavian Clinic in Sari in 2019-2020. Simple randomization was substituted in experimental (n = 15) and control (n = 15) groups. However, no intervention was performed on the control group during this period. The Simon and Gaher (2005) Emotional Distress Scale and the Doyce and Woodwall (2010) Scale were used to collect data. mean, standard deviation and multivariate analysis of covariance were used to analyze the research data.

The results showed that the effect of Mindfulness-based cognitive therapywas on distress tolerance (F= 28.74, P<0.001) and on Cognitive flexibility (F= 31.57, P<0.001).

Considering the effectiveness of mindfulness-based cognitive therapy on anxiety tolerance and cognitive flexibility, it seems that this treatment can be used to reduce psychological problems in patients with type 2 diabetes.