مجله دانشکده پزشکی اصفهان
پیاپی 678 (هفته دوم شهریور 1401)

Methicillin-resistant Staphylococcus aureus (MRSA) causes various infections in susceptible individuals who are resistant to antibiotics, resulting in high morbidity and mortality rates. This study aimed to investigate the adjuvant effect of selenium Nanoparticles (SeNPs) for the purpose of developing an effective vaccine to prevent and reduce the complications of MRSA.

Autolysin recombinant protein, expressed by IPGD and purified by Ni-NTA chromatography was used to develop the vaccine. Together with alum adjuvant, SeNPs produced in two synthetic and biogenic forms were used as a co-adjuvant to increase the vaccine’s efficacy. Four groups of BALB/c mice were subcutaneously injected with three doses of different vaccine combinations. In order to evaluate humoral immunity, the ELISA test was used to measure total IgG, IgG1, and IgG2a levels. The 30-day survival rate of experimental mice was recorded after they were exposed to a bacterial challenge test of MRSA (1.5 ×108 CFU).

In both groups receiving autolysin recombinant protein with synthetic SeNPs and with biogenic SeNPs, total IgG were higher than the control group. Compared to the control group, IgG1 and IgG2a increased more in the two previously mentioned groups. After the bacterial challenge test, the survival rate of vaccinated mice was higher than that of the control group.

The results showed that, as a co-adjuvant, synthetic and biogenic SeNPs in combination with autolysin recombinant protein could improve the humoral immune system against MRSA.

Patients who suffered coronary artery disease (CAD) experience a lower quality of life.This study aimed to investigate the mediating role of the illness perception variable in the relationship between mentalization and personality type D with quality of life in patients with coronary heart disease.

The present study was performed using correlation modeling using structural equation modeling. Based on Cohen's sample size determination table, 210 patients with coronary heart disease were enrolled by random sampling method. Questionnaires of personality type D, quality of life (SF-36), mentalization (Ment S) and disease perception (IPQ) were used to gather data for this study which were completed by the patients themselves. After data collection, the relationship between the two variables with Pearson correlation and the interactive relationship in the structure of the theoretical model drawn in this study was evaluated using structural equation modeling.

The final research model had a very good fit. The results showed a direct effect of D personality type and disease perception on quality of life but the direct effect of mentalization on quality of life was not significant. Also, the indirect effect of personality type D and mentalization through disease perception on quality of life was statistically significant.

Cognitive and emotional representation of the disease, which is the illness perception, can mediate the relationship between psychological and personality variables with quality of life. Therefore, in improving the perception of the disease to improve the quality of life of patients, personality, behavioral and psychological variables can serve as targets of intervention.

The aim of this systematic review was to evaluate and identify the latest evidence on the feasibility and accessibility of telerehabilitation services in the prevention, diagnosis, treatment and control of patients with COVID-19.

The studies were retrieved from the authoritative scientific databases Embase, Web of Science, Scopus, PubMed on November 25, 2021. Then, the gray literature was scrutinized using the Google search engine to identify the latest possible evidence. Randomized controlled trial studies and protocols that used the telerehabilitation approach as an intervention to improve the condition of distant COVID-19 patients were part of the inclusion criteria. In order to assess the quality of the studies entering this study, the Joanna Briggs Institute Critical Appraisal Checklist for Randomized Controlled Trials was used. The same checklist was used for data extraction.

A total of 7 eligible articles were obtained in this review. The quality assessment results showed that there was no significant bias in the studies and all studies were eligible to be included in our study. In two studies (3.7, 43%), telerehabilitation was used to support COVID-19 patient, both of which reported significant improvement in endurance, functional and physical condition of patients with telerehabilitation. However, no significant improvement was found in patients' pulmonary function parameters. In contrast, another study showed a significant improvement in shortness of breath and aerobic capacity of patients in the intervention group compared to the control.

The results of the systematic review showed that a small number of small-scale studies on telerehabilitation have been performed for patients with COVID-19. However, it seems telerehabilitation has great potential to improve the functional, respiratory, physical condition and ultimately improve the quality of life of patients with COVID-19.