مجله پزشکی دانشگاه علوم پزشکی تبریز
سال چهل و پنجم شماره 2 (پیاپی 164، خرداد و تیر 1402)

Enjoying family life and interpersonal or marital relationships as well as feeling satisfied are among the main desires of every person. Numerous studies show that self-differentiation is one of the most important intrapersonal and interpersonal elements in families, especially in Iranian ones, which is also associated with other psychological phenomena.

This study was performed using the meta-analysis technique by integrating the results of various studies conducted in the field of consequences and preconditions of their differentiation in Iranian families. To this end, 33 eligible and acceptable studies were selected and meta-analyzed. Data collection was performed using a meta-analysis checklist. This study was based on 6205 samples and 33 sizes of effect.

The findings indicated that the effect size of the predictors and consequences of self-differentiation in Iranian families had a large-sized average effect (r=0.46, SE=0.06,1, P<0.001).

Based on the findings, self-differentiation in the position of predictor and criterion variables was related to different psychological characteristics in Iranian families.

The results of this study, in addition to enriching national science and knowledge and guiding future studies, provided a comprehensive understanding of this psychological characteristic in the cultural and social context. Also, it can have special practical consequences in designing and developing treatment protocols based on self-differentiation in families according to the culture of our country.

Gastric Cancer (GC) is a common gastrointestinal tumor, and its incidence is increasing. The pathogenesis of GC is very complex and remains unclear. Recent basic studies of GC have focused on gene expression dysregulation. Accumulating evidence has demonstrated that thioredoxin-interacting protein (TXNIP) is abnormally expressed in a variety of malignant tumors but it is obscure in GC. This study aimed to compare the expression of the TXNIP gene in cancerous and adjacent tissue of gastric cancer and evaluate its clinical significance in the prognosis and survival analysis of gastric cancer patients.

A total of 50 tumor tissues and marginal non-tumor control tissues were obtained from GC patients. Also, TXNIP gene expression levels were evaluated by real-time PCR. Meanwhile, bioinformatic approaches were used to evaluate TXNIP expression in two different cohorts of GC patients. A data mining study was also performed to determine the prognostic role of TXNIP expression in the overall survival of GC. Furthermore, a pan-cancer analysis of TXNIP expression was performed using TCGA data.

The TXNIP gene was down-regulated in tumor samples with a fold change of 0.33, and the same results were repeated in bioinformatics analysis. Decreased expression of TXNIP was significantly associated with metastasis, poor differentiation, and drug abuse. Our results provided evidence that TXNIP gene expression level is positively correlated with the overall survival of GC patients. Pan-cancer analysis of TCGA data revealed down-regulated TXNIP in a variety of malignant tumors.

This study established low TXNIP expression as a prognostic biomarker in GC. It also revealed that the decrease in TXNIP expression likely favors metastatic GC.

Evaluation of TXNIP expression is informative in the prognosis of GC patients.

Iron deposits impair neurons and cause cognitive disorders through different pathways. Today, with the help of quantitative susceptibility mapping (QSM), iron accumulations in different brain areas can be evaluated and measured.This research aims to identify the changes of iron deposits in the brain nuclei in different stages of cognitive disorders using the QSM technique and introduces biomarkers for the early diagnosis of these disorders.

The data of thirty-five participants with normal cognitive conditions and forty six patients with cognitive disorders, classified into four different groups based on the severity of the disorder, were downloaded from the ADNI database. After determining the regions (ROIs) with the FSL automatic segmentation tool, the mean QSM values of twelve brain nuclei were determined with the help of Slicer software, and SPSS software was used for statistical analysis.

There was an inverse correlation in the left putamen nucleus of LMCI group (P=0.041). Direct correlation between age variable and QSM values of the left putamen nucleus (P=0.000078) and right putamen nucleus (P=0.000017) of the control group were reported.

As the severity of disorders increases in the LMCI group, the number of paramagnetic deposits, such as iron, in the left putamen nucleus increases. Therefore, the QSM values of the left putamen nucleus can be used as an indicator of the severity of the disorder in the advanced stages of cognitive disorders.

Iron deposits cause damage to neurons and cause cognitive disorders through various pathways. Today, with the help of the quantitative susceptibility mapping technique, the numeral of iron accumulations in different brain areas can be evaluated and measured. This research aims to identify the changes of iron deposits in the brain nuclei in different stages of cognitive disorders by using the Quantitative susceptibility mapping (QSM) technique to introduce biomarkers for early diagnosis of these disorders.

Breast cancer is still considered as one of the most important diseases, the most common cancer, and the second cause of death among women. It is necessary to evaluate the factors responsible for breast cancer (e.g., marital stress) since majority of the breast cancer cases in Iran are active young women hoping to live a normal social and sexual life, and because breast emptying has destructive effects on self-image and marital satisfaction. Therefore, this study aimed to determine the relationship between satisfaction and marital stress in mastectomy surgery.

In this cross-sectional study, 120 married women with breast cancer were selected using available methods. The data were collected using a questionnaire with three parts including demographic questions, Enrich marital satisfaction, and Stockholm marital stress. Parametric tests and analysis of variance were used to analyze the data.

There was no significant relationship between marital satisfaction/marital stress and type of mastectomy surgery (P>0.01). Also, there was no significant relationship between marital satisfaction/marital stress and demographic variables (P>0.01).

It was concluded that the marital satisfaction and marital stress had no significant relationship with the type of breast surgery.

Type of breast surgery had no effect on marital stress and satisfaction.

Poor landing mechanics and core stability are risk factors contributing to knee injuries, especially Anterior Cruciate Ligament injury, in military cadets. This study aimed to investigate the effect of the Stop-X injury.

In this quasi-experimental study, 40 cadets were purposefully recruited and randomly assigned either to an intervention (INT, n=20, age=19.05±0.68 years, height=1.75±0.06 m, weight=72.70±4.18 kg, BMI=23.77±1.68 kg/m2) or control group (n=20 participants, age=18.70±0.65 years, height=1.77±0.06 m, weight=74.10±4.90 kg, BMI=23.53±2.24 kg/m2). Landing Error Scoring System and McGill’s stability tests were used to evaluate landing mechanics and core stability at the baseline and the end of the study. Then, the INT group performed the Stop-X program as a warm-up program before each training session for eight weeks, whereas the CON group carried out their routine warm-up program during this time. Mann-Whitney U and ANCOVA tests were used to evaluate the changes.

The results obtained in the intervention group in post-test in comparison with the control group showed that there was a significant reduction in Landing Error Scoring System test scores (P=0.001), and there were significant enhancements in core stability tests (P=0.001). Moreover, the results in the intervention group revealed significant reduction in Landing Error Scoring System test scores (P=0.001) and significant enhancements in core stability tests (P=0.001), but there no significant differences were observed in the control group (P>0.05).

In sum, the Stop-X injury prevention program may have improved landing mechanics and enhanced core stability in military cadets. Thus, Stop-X program may have reduced the risk factors associated with knee injuries in military cadets.

Our findings suggested that the Stop-X injury prevention program may have been used as a suitable warm-up program in military service instead of traditional warm-up to improve the neuromuscular and biomechanical risk factors.

The birth of a premature baby needing to be hospitalized in the neonatal intensive care unit (NICU) endangers the initial mother-baby relationship, affecting mother-baby attachment. Therefore, it seems necessary to provide mothers of premature babies with appropriate nursing support. In the present study, we aimed to investigate the effects of spiritual self-care training on the mother-baby attachment of mothers giving birth to premature babies hospitalized in the NICU.

This was a semi-experimental study with pre-test/post-test design conducted on 60 mothers with babies admitted to the NICU of Taleghani Hospital of Ilam (30 participants in each of the intervention and control groups).Two questionnaires were used for data collection, including a demographic information questionnaire and the Maternal Postnatal Attachment Scale (MPAS). Five self-care training sessions (45 minutes each) were held for mothers of the intervention group according to a self-care booklet prepared by the researcher. The attachment questionnaire was again completed after one week of the last training sessions by all participants, and the data were analyzed using SPSS version 22 software. Descriptive statistics were used to present quantitative (mean ±SD) and qualitative (frequency, %) variables. The normality of the data was checked using the Kolmogorov Smirnov test, and the MANOVA and univariate analysis of covariance (ANCOVA) tests were used to investigate the effects of the training on mother-baby attachment. The statistical significance level was considered P<0.05.

The means of the total attachment score in the intervention and control groups were obtained as 51.73 and 56.43 at the pretest and 53.36 and 49.77 at the post-test, respectively, indicating that spiritual self-care training was effective in improving mother-baby attachment (P<0.05).

Our results showed that spiritual self-care training augmented mothers’ attachment to their babies hospitalized at the NICU. According to the results of the present study, it is suggested to pave the ground in clinical environments by educating nurses and caregivers and supporting the mother and the baby through spiritual self-care interventions to promote maternal attachment and improve their conditions.

According to the results of the present study, it is suggested to pave the ground in clinical environments by educating nurses and caregivers and supporting the mother and the baby through spiritual self-care interventions to promote maternal attachment and improve their conditions.

Organizational socialization is a process of teaching employees to successfully integrate into a new organization. Socialization needs to be presented in the form of a coherent pattern.

This study aimed to design a model for the organizational socialization of employees in Iran’s healthcare system using the grounded theory method. Semi-structured interviews were used to extract the main factors influencing the socialization of employees. In-depth interviews were conducted with 19 experts, including specialists, managers, and employees of the healthcare system using the purposeful sampling method. We extracted 49 concepts and 19 categories using the foundation data method in the open coding stage.

The findings showed that developing a model for organizational socialization in Iran's banking system requires the senior managers’ constant support, social responsibility, and socializing organizational culture. The values, norms, and roles expected from the individual should be transmitted clearly.

An organizational socialization model can enhance the socialization of employees in Iran’s healthcare system.

The development of socialized human resources, socialized competitiveness, and socialized basic management requires the Bdesign of socialized human resources processes, an evaluation system, a resource allocation system, socializing succession, and value creation.

Most common oral lesions during pregnancy are subjected to oral hygiene and gaining knowledge about them can improve oral health during this period. Thus, this study aimed to assess the knowledge of pregnant women in Isfahan about common oral lesions.

This descriptive-analytical cross-sectional study included 210 pregnant women aged 18-45 years who were non-dentists referring to private offices in three areas in Isfahan. A researcher-made questionnaire was used for data collection which determined the average knowledge and performance scores of the subjects as well as the relationship between knowledge and age, education, pregnancy, occupation, and their living area. Also, a one-way analysis of variance as well as Pearson correlation coefficient and Spearman's rank correlation coefficient were used for data analysis.

The knowledge and performance levels of most women were average. The knowledge level of pregnant women were directly related to their performance. That is, the more knowledge level, the higher performance score. The knowledge score was not related to age, employment in the non-healthcare section and being a housewife, place of residence and birth, but was directly related to employment in the healthcare section and education. The performance score was related to age, employment in the healthcare section, place of residence and education, but was notrelated to birth rank.

The knowledge of pregnant women in Isfahan was moderate and needed to be increased. This knowledge was not much different in various groups of society, thus it should be increased in different ways.

Increasing the knowledge of pregnant women about the types of lesions and their prevention methods can reduce their prevalence which also will lead to a decrease in worries during this period.