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Nutrition and Food Security - Volume:9 Issue: 1, Feb 2024

Journal of Nutrition and Food Security
Volume:9 Issue: 1, Feb 2024

  • تاریخ انتشار: 1402/11/24
  • تعداد عناوین: 18
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  • Amrollah Sharifi* Pages 1-6

    In food intake studies, converting eaten foods into calories and nutrients and other food components using books and tables of food ingredients is a very time-consuming and error-prone task. ShaFA is new Microsoft Windows-based software for food component derivation of individual and group food intake data. This software is developed using C sharp programming language. Microsoft Access has been used to put the information of 8790 food types and their 85 food components based on the USDA-SR28 in the database of software. The user is capable to search in the database for desired food by the name or special code of the food and select them for each person. Each person’s food intake data can be stored via allocating an exclusive ID. Finally, the user can get a report of the imported data in a new window, and also can get a Microsoft Excel export which can be imported into statistical software such as SPSS and STATA. Each research project data can be stored in a file with the unique extension (ShaFA) which can be opened and edited in any system that its operating system is Microsoft Windows, and has ShaFA software installed on it. This software can provide researchers with valuable information in a short time, especially nutritional epidemiology studies. It can also be used in food industry to extract the information needed to label and complete food information table for a variety of food industry products.

    Keywords: Nutrition assessment, Diet surveys, Nutrients, Food analysis, Software
  • Ameneh Marzban*, Fateme Sadeghi-Nodoushan Pages 7-9

    Disaster is a tragic event which causes excessive mortality, suffering, and financial damage. One of the most important basic needs of people after a disaster is food. Providing and distributing healthy, adequate, and hygienic food is one of the biggest challenges which managers always face in a crisis because disasters have different effects on food situation and nutrition of the affected area (Ireton-Jones et al., 2019). Therefore, one of the major consequences of disasters is the reduction of energy and food supply sources. Evaluation of available food sources, proper rationing, prioritization of high-risk groups such as children and pregnant or lactating women, and food distribution should be considered according to the assessment of minimum energy and nutrient requirements

    Keywords: disasters, nutrition, foods, crisis
  • Atefeh Kohansal, Kimia Leilami, Mozhgan Hafizi, Alireza Rafiepour, Mehran Nouri, Zahra Sohrabi, Marzieh Akbarzadeh* Pages 10-17
    Background

    Due to the increasing prevalence of body image concern (BIC), especially in adolescent girls, and its potential associations with lifestyle factors and anthropometric indices, the present study was designed to evaluate the associations between BIC with anthropometric indices and dietary intake in adolescent girls.

    Methods

    In this cross-section study, 210 adolescent girls aged 14-16 years were selected from high schools in Shiraz, Iran. Their anthropometric and demographic information were carefully recorded. Physical activity data were recorded through the International Physical Activity Questionnaire and information on dietary intake was collected using a 24-hour recall. To assess BIC, Littleton BIC questionnaire was applied. Regression analysis was used to assess the associations between variables.

    Results

    Based on the results, 121 girls (55.8%) of the participants had no BIC, 70 (32.3%) had little, and 26 (12.0%) had medium BIC. Mean values of BMI, BMI for age centile, and z-scores were significantly different between BIC subgroups (P=0.008, 0.023, and 0.009, respectively). Mean values of height, and height for age centile, and z-scores were significantly different between BIC subgroups (P=0.018, 0.021, and 0.029, respectively). Risk of BIC increased, by 77% with 1 unit increase in z-score of height for age. Also, 1 kcal increase in daily energy intake led to 1% decrease in the risk of BIC.

    Conclusion

    BIC was associated with lower calorie intake and higher z-score of height for age in adolescent girls.

    Keywords: Body image concern, Anthropometric indices, Dietary intake
  • Mahboubeh Mirhosseini*, Azadeh Afra, Fatemeh Barzegari Banadkooki, Fatemeh Banifatemeh Pages 18-33
    Background

    This research was conducted to design a bionanocomposite film for meat packaging with regard to environmental aspects.

    Methods

    Cellulose nanoparticles (CNPs) were used as nano-reinforcing factors were generated using non-edible agricultural by-products. The bionanocomposite film which was recently developed contains CNPs and chitosan (CS); then, the nanocomposites were explored via SEM, FTIR, agar disc diffusion tests and X-ray crystallography (XRD). Finally, the film was used to pack meat pieces.

    Results

    Investigation of the morphological and physical reports of the solid films indicated that the CNPs are well scattered in bionanocomposite film. The addition of CNPs within a CS improved Young’s modulus by about 12135% and the tensile strength by 583%. In addition, XRD photographs indicated that CNP peak appeared after being added to CS context. Antimicrobial activity demonstrated that nanocomposites exerted restrictive effect on Escherichia coli, Pseudomonas aeruginosa, Listeria monocytogenes, and Staphylococcus aureus bacteria. Using CS-nanocellulose composite as a packing film on meat surface leads to decreasing bacteria growth compared to nylon packing materials at 4˚C after 8 days of storage.

    Conclusion

    Findings indicated that the recently designed CNP-CS films are a better replacement for common food packaging substances.

    Keywords: Biodegradable plastics, Chitosan, Cellulose, Food packaging, Nanoparticles, Nanocomposites, Meat, Waste products
  • Reza Rahimirigi, Masoud Fehresti-Sani*, Ahmad Fatahi, Mohammad Reza Pakravan-Charvadeh Pages 34-44
    Background

    Food security and productivity are very important variables that affect social welfare and production level. Since a large proportion of employees in Semirom are engaged in apple gardening, this study aims to investigate the effect of increasing the productivity of all factors of apple production in improving the level of food security in Semirom city.

    Methods

    In order to answer the research questions, using Cochran's formula, 139 gardeners were selected and the required data were collected through interviews and completing a questionnaire by cluster sampling in 2020. First, the productivity of all factors of production and the level of food security of the surveyed households were measured using the Household Food Insecurity Access (HFIA) index.

    Results

    The results of this analysis showed that gardeners are not in a good food security situation. Then, using Shazam software and estimating the coefficients of the variables in the logit model, the relationship between productivity and food security was investigated. The results showed that productivity had a positive and significant effect on food security of the studied farmers. Based on the final effect, the variables of productivity, income, and savings had the greatest effect on food security of the farmers. In order to create more employment and increase income for gardeners and their families, apple-related processing industries should be established.

    Conclusion

    The results of the study showed that apple gardeners of Semirom do not have good food security. It is recommended that younger people be educated by experienced farmers in the region.

    Keywords: Food security, Organizational productivity, Social welfare, Multifactorial causality
  • Mohammad Reza Alipour, Vakil Asadolahi, Mohammadtaghi Sarebanhassanabadi* Pages 45-51
    Background

    Heart palpitation is a common complaint defined as an unpleasant or abnormal heartbeat feeling. This study aimed to investigate the effectiveness of Crataegus extract on the relief of heart palpitations and anxiety in adolescents.

    Methods

    This is an interventional quasi-experimental study performed from February 19, 2016 to February 19, 2017 on 120 adolescents aged 13 to 19 years with a complaint of heart palpitations, referring to heart clinic in Afshar Hospital of Yazd. The participants' demographic information, heartbeat feeling, Hamilton anxiety scaling, blood pressure, heartbeat rate, and electrocardiogram (ECG) were recorded. Patients were first treated with 20 drops every 8 hours for three days and then 25 drops every 8 hours for one month with Crataegus edible drops. They were then re-evaluated for heart palpations and anxiety.

    Results

    Of 120 adolescents referring to Afshar Hospital with heart palpitations, 98 of participants (81.7%) experienced improvement. Mean differences in systolic blood pressure, heart rate, and anxiety scores before and after treatment with Crataegus extract decreased significantly by 1.71, 8.52, 6.55, respectively, but the mean difference in diastolic blood pressure increased by 1.46 (P<0.05).

    Conclusion

    According to the results, Crataegus extract might be effective in reducing palpitation and anxiety in adolescents.  Further studies are suggested to approve the results of the study.

    Keywords: Crataegus extract, Heart palpitation, Anxiety
  • Elham Zarean, Pardis Sadeghi, Tina Jafari, Afsaneh Malekpour Tehrani, Samaneh Torkian* Pages 52-58

    Evidence suggests that dietary micronutrients may be associated with depression. The role of selenium as a risk or protective factor for depression was contradictory. Therefore, this study aimed to investigate the association between serum selenium concentrations and depression.

    Methods

    This case-control study was conducted from 2018 to 2020 in Shahrekord, Iran. The case and control groups included patients with or without depression, respectively. Seventy-two participants were selected using the conventional method. In addition to recording demographic variables, the blood selenium concentration of the participants was measured.

    Results

    There was no difference between case and control groups in terms of mean levels of blood selenium (P>0.05). Results showed that there was no statistically significant interaction between the effects of gender and group (P=0.51), age and group (P=0.13), Body mass index (BMI) and group (P=0.52) on blood selenium concentrations. However, females had significantly more selenium concentrations than males in both groups (P=0.005).

    Conclusion

    Despite some confirming evidence for the association of depression and blood selenium concentration, this study did not show such a relationship. However, blood selenium concentration was higher in women than men in both groups.

    Keywords: Selenium, Depression, Patients, Iran, Case-control studies
  • Marzieh Dehghani, Nasrin Omidvar*, Azam Doustmohammadian, Zeinab Tork, Ayoub Arvand Pages 59-68

    Formal education in any society should foster all aspects of students' growth. However, studying the curriculum of the country academic period indicates null food and nutrition. Nutrition, as an essential factor in the health of students, can play an effective role in their academic progress. This study aimed to analyze the content of school textbooks concerning food and nutrition literacy (FNLIT) concept and its components in Iran.

    Methods

    This study is a content analysis of school textbooks during 2020-2021 academic year. All school textbooks published in 2020 for elementary (grades 1st to 6th), junior high school (grades 7th to 9th), as well as high schools (grades 10th to 12th) were included. Content analysis of the textbooks was conducted based on Krippendorf framework using FNLIT component checklist. The reliability assessment using Holsti method was 85.29% for elementary school textbooks and 84.78% for junior high school and high school textbooks.

    Results

    The cognitive domain of FNLIT had the highest frequency (92%) within the text, images, and practice questions of the elementary school textbooks, followed by very few references regarding the skill domain (7%). The value-attitude domain was largely unnoticed (1%). In junior high school textbooks, the total number of FNLIT components was 439, of which the cognitive domain of 308 (70.16%) had the highest frequency, followed by the skill domain with 96 units (21.86%), while only 35 units were identified regarding the value-attitude domain (7.97%). In high school textbooks, 342 units of analysis were identified, 82.16% of which were related to cognition, 14.03% value-attitude domain, and only 3.80% were related to the skill domain.

    Conclusion

    Meager attention is given to FNLIT and its components in school textbooks in Iran, especially concerning skill and value-attitude domains.

    Keywords: Content analysis, Literacy, Schools, Textbooks, Iran
  • Payam Sharifan, Hamideh Ghazizadeh, Susan Darroudi, Alireza Ghodsi, Sara Saffar Soflaei, Davoud Tanbacoochi, Mohammad Reza Fazl Mashhadi, Mohammad Amin Mohammadi, Ali Ebrahimi Dabagh, Sara Moazedi, Maryam Mohammadi Bajgiran, Gordon Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan * Pages 69-80

    Vitamin D deficiency is a worldwide condition, which has been linked to a variety of health-related issues. Vitamin D can be beneficial to cardiovascular patients and those suffering from depression and anxiety, based on Survey of Ultraviolet Intake by Nutritional Approach (SUVINA study), ,showing the potential effects of vitamin D-fortified dairy products on anxiety, depression, and stress in subjects with cardiovascular disease (CVD) risk factors.

    Methods

    It was a quadruple-blind randomized controlled trial. Individuals were randomly allocated to one of four groups: fortified low-fat milk (FM), non-fortified low-fat milk (NFM), fortified low-fat yogurt (FY), and non-fortified low-fat yogurt (NFY). FM and FY groups were fortified with 1500 IU nano-encapsulated vitamin D3. Anthropometric parameters as well as depression, anxiety, and stress scores were measured at baseline and after a ten-week trial in Mashhad, Iran.

    Results

    Totally, 289 participants (143 men, 146 women) with a mean age of 41.86±7.81years were enrolled in the study. There was no statistical difference between the scores of depression, anxiety, and stress in participants with and without CVD risk factors (P>0.05).  No statistical difference was found in the subgroup analysis based on milk and yogurt consumption.

    Conclusions

    Fortified low-fat milk containing 1,500 IU of vitamin D has no impact on improving depression, anxiety, and stress during ten weeks. However, further studies with higher vitamin D doses for a longer duration are recommended.

    Keywords: Vitamin D, Fortification, Anxiety, Depression
  • Jemal Abdulkerime Mohammed, Asegie Asrat Mulat* Pages 81-91

    In order to combat malnutrition and micronutrient deficiencies, Nutrition Sensitive Agriculture (NSA) gives nutrient-dense foods, dietary diversity, and food fortification the highest priority. This micro-intervention project's goal is to increase home-gardening system's contribution to raising women's dietary diversity score (WDDS) by diversifying family farming practices.

    Methods

    In Ethiopia's Boru-Meda Kebele, The authors applied the intervention to 40 specifically chosen female beneficiaries between the ages of 15 and 49. FAO's standardized questionnaire was used as a tool to conduct an initial and end-line dietary diversity survey by giving careful consideration to cultural and religious elements. The qualitative information was also gathered using case studies, key informant interviews, and focus group discussions.  

    Results

    The local population's diet was dominated by staple cereal crops, and women were less knowledgeable about home gardening and diverse diets. Before intervention, the average number of food groups produced and consumed was 2.63±1.00 and 3.68±1.16 respectively. The intervention enhanced the WDDS to 6.13±0.76, and the production diversity to 5.63±0.90. The intervention changed the community's consumption and production patterns, especially among women.

    Conclusion

    Home-garden agriculture helps to increase WDDS. As a result, development partners must concentrate on farming system diversification by increasing the accessibility of vegetable seeds and educating local farmers about the contribution of diversified vegetable production and consumption. Strengthening the cooperation among stakeholders and maintaining monitoring of activities should also be given due emphasis

    Keywords: Dietary diversity, Diversified production, Home garden agriculture, Nutrition sensitive agriculture, Women dietary diversity
  • Zahra Veysi, Azadeh Dehghani, Mahnaz Sanjari, Zhila Maghbooli*, Khadijeh Mirzaei Pages 92-103

    There is a high prevalence of perceived stress among nurses. Recent studies have shown that omega-3 fatty acids and genetic variants contribute to perceived stress. This study aimed to examine interactions between vitamin D receptor (VDR) gene FokI polymorphism and omega-3 fatty acids on perceived stress score and serum cortisol levels in nurses.

    Methods

    A total of 268 Iranian nurses (248 women; 20 men) participated in this cross-sectional study. Omega-3 fatty acids and perceived stress score of participants were evaluated using a 3-day food record and the Perceived Stress Scale (PSS)-10, respectively. Serum cortisol concentrations were evaluated by ELISA. VDR FokI polymorphism was genotyped using the restriction fragment length polymorphism method.

    Results

    No significant relationship was found between omega-3 fatty acids with perceived stress score or cortisol level in FF genotype carriers, but lower intake of PUFA was related to higher cortisol level (P=0.04) in Ff carriers. Significant interactions were observed between VDR FOKI polymorphism and intakes of eicosapentaenoic acid (EPA) (P Interaction=0.06), linoleic acid (P Interaction=0.06), and docosahexaenoic acid (DHA) (P Interaction=0.06) on serum cortisol, so that lower intake of EPA, linoleic acid, and DHA was associated with an increase in cortisol levels in individuals with ff genotype. Moreover, in carriers of ff genotype, lower intake of EPA was related to the elevated perceived stress score (P Interaction=0.06).

    Conclusion

    FokI polymorphism interacts with omega-3 fatty acids (EPA, linoleic acid, and DHA) to increase cortisol level and with EPA to increase perceived stress score in nurses.

    Keywords: Fatty acids, Omega-3, Eicosapentaenoic acid, Docosahexaenoic acids, Linoleic acid, Receptors calcitriol, Gene-environment interaction
  • Kiumarth Amini, Adeleh Sahebnasagh, Ronak Amini, Solomon Habtemariam, Farhad Najmeddin, Mojtaba Mojtahedzadeh* Pages 104-115

    The coronavirus disease of 2019 (COVID-19) may be considered sepsis on the basis that all the pathological events and the subsequent organ-to-organ interaction in sepsis also occur in COVID-19. In this article, the authors first discussed the rationale for the use of vitamin C (Vit-C) in sepsis and septic patients. They also reviewed the role of a high dose of Vit-C in COVID-19, which included clinical trials designed for the management of this viral disease.

    Methods

    The researchers explored databases of PubMed, Scopus, ISI Web of Science, and Google Scholar. Data were extracted to assess the effects of Vit-C in septic patients and also the efficacy of supplementation with a high dose of Vit-C regarding the clinical outcomes of patients with COVID-19.

    Results

    Recent research findings indicate that severe inflammatory responses (cytokine storms) and oxidative stress are important causes for the high mortality in COVID-19 patients. It seems, however, that administering high doses of Vit-C can offer a therapeutic benefit. High doses of intravenous Vit-C, with its antioxidant properties and pleiotropic functions, could attenuate the tissue damage caused by excessive levels of free radicals following the cytokine storm and septic shock in severe cases of the disease.

    Conclusions

    Recent literature suggests that high doses of Vit-C have a potential role in reducing mortality and intubation rates in critically ill COVID-19 patients. However, determining the optimal duration and dose of Vit-C in these patients requires further studies.

    Keywords: COVID-19, Vitamin C, Cytokine storm, Critically ill, Sepsis
  • Mojtaba Fattahi Ardakani, Nasim Namiranian, Mohammad Afkhami Ardekani, Moradali Zareipour*, Ali Asadian, Sara Heydari Pages 116-131

    Diabetes mellitus is a chronic disease which affects all aspects of human life. Medical herbs have become increasingly popular as complementary therapeutic measures for patients with diabetes. Thus, the present research aims to explore the consumption of medical herbs in patients with diabetes in Eastern Mediterranean Regional Office (EMRO) countries through a meta-analysis.

    Methods

    The following keywords were searched: medicine, medicinal plants, healing plants, medicinal herbs, use, usage, frequency of use, prevalence, diabetes patients, type 2 diabetes, adults with diabetes, and EMRO countries. The databases searched included Scopus, PubMed, Web of Science, and Google Scholar.

    Results

    A total of 3,542 papers were found. After omitting repeated or irrelevant papers, 70 papers were retained. An analysis of the abstract and full text of papers led to the retention of 35 papers. A great variance was found regarding the rate of consuming medical herbs in the papers (16.8-97.7%). The relative frequency of consuming medical herbs was 38% (95% CI: 33-44). Moreover, the most prevalent herbs were fenugreek (19%), cinnamon (18%), black seed (14%), white lupinus (13%), and olive (13%) with a 95% confidence interval. About 70% of patients (95%CI: 62-79) did not inform their physician of their herbal medicine consumption.

    Conclusion

    In light of the present findings, it can be concluded that patients with diabetes use a wide range of medical herbs. Thus, health specialists and physicians need to be aware of the possible synergic or moderating effect of herbal medicine on the therapeutic measures taken for diabetes.

    Keywords: Systematic review, Diabetes mellitus, Complementary therapies, Plants, Medicinal
  • Fatemeh Toorang, Bahareh Sasanfar*, Hamed Pouraram, Soheyl Eskandari Pages 132-143

    There is a growing concern about the health-threatening effects of pesticide residues in fruits and vegetables worldwide. This study systematically reviewed the published data on pesticide residues in Iranian fruits and vegetables to clarify the gap in this issue.

    Method

    The authors systematically searched PubMed, Google Scholar, Scopus, SID, and Iran Medex to find published studies on pesticide residues in Iranian foods without time and language restrictions. The title and abstract of all articles were evaluated after removing duplicate articles (2289 articles) by two independent reviewers. Finally, 25 articles were found that reported pesticide residues in fruits and vegetables. There was a great variation in measurement methods and pesticides reported across studies, which precluded meta-analysis. Therefore, a summary of the included studies was only reported.

    Results

    Twenty-four studies reporting pesticide residues in Iranian fruits and vegetables were included. The percentage of Iranian fruits and vegetables contaminated with pesticides exceeding the maximum residue limit (MRL) was less than 10% in most studies. Contaminated samples were collected mainly from cultivated areas such as fields, orchards, or greenhouses.

    Conclusion

    Pesticide residues in food have not been systematically reported in Iran. It was found that only limited articles were published by academic societies on this issue. Considering the current scenario, there is an urgent need to facilitate reliable and continuous measurements of toxic residues in Iranian food.

    Keywords: Pesticide, Fruit, Vegetable, Systematic review, Iran
  • Mehrnoosh Shirdeli, Fatemeh Yaghoubi, Fateme Sadeghi-Nodoushan, Ameneh Marzban* Pages 144-151

    Fasting during Ramadan is an obligatory duty for all Muslims in the world. One of the most common side effects of fasting is constipation if fasted people do not follow a proper diet. Therefore, the purpose of this study is to review the effect of synbiotic foods on reducing and treating constipation in fasted people during Ramadan.

    Methods

    Search engines including PubMed, Scopus, Embase, Science Direct, Google scholar, Magiran, and scientific information database (SID) were applied with keywords such as Fasting, Synbiotics, Constipation, Ramadan, Digestive System, Probiotics and Prebiotics to find related articles published up to 2022. Finally, 45 articles were included in the review.

    Results

    Synbiotics are actually oral supplements and a mixture of probiotics and prebiotics. The use of these compounds, in addition to reducing the complication of constipation, has other benefits that can be a step towards reducing the use of drugs and changing lifestyle not only this month but also at other times.

    Conclusion

    The use of fiber-containing compounds, beneficial for the activity of the gastrointestinal tract, both microbial and to improve its peristalsis, is especially necessary in the elderly, whose peristalsis has decreased due to aging. The placement of synbiotic foods such as synbiotic dairy products will help to control this complication due to the presence of prebiotics and beneficial probiotics.

    Keywords: Fasting, Sinbiotics, Constipation, Ramadan
  • Ameneh Marzban, Mohsen Dowlati*, Fateme Sadeghi Nodoushan Pages 152-159

    Today, the world is facing the problems of population growth, urbanization, increasing need for food, depletion of water resources, and environmental degradation. Therefore, the present study investigates the impact of urban agriculture on food security.

    Methods

    Search engines including PubMed, Scopus, Embase, Science Direct, Google scholar, Magiran, and scientific information database (SID) were applied with keywords such as population growth, food security, sustainable development, urban agriculture, food system to find related articles published up to 2022.

    Results

    The impact of urban agriculture on food security can be seen through several factors such as nutritional stability, food availability, affordable food supply, and revenue generation through sales.

    Conclusion

    Urban agriculture refers to production of food products in urban environment, where food is produced on rooftops, backyards, gardens, or in public open spaces. This work proposes new opportunities for sustainable development and urban management to make significant changes in living environment, health and land management. Furthermore, this research provides the poor in the city a chance to achieve food security by reducing household food costs

    Keywords: Population growth, Food security, Sustainable development, Urban agriculture, Food system
  • Maryam Hamidian Shirazi, Alireza Mollaei, Atena Ramezani, Amirreza Hamidian Shirazi, Najmeh Hejazi * Pages 160-172

    There is a direct relationship between taking soy isoflavones and higher bone density, but there is a paucity of studies examining the relationship between flavonoid consumption and fracture risk. This study aimed to assess the bone fracture and its relationship to soy product intake by performing a systematic review.

    Methods

    Scopus, PubMed, and Web of science were searched to find studies on the effect of soy isoflavones on bone fracture, without any time and language of publication restrictions. Key words of SoyMilk, soymilk, soybeans, soybean, soy, soya, Isoflavones, Isoflavone, ipriflavone, equol, genistein, daidzein, glycitin, fractures, and broken bone were used.

    Results

    From a total of 1675 articles, 27 studies (cross-sectional studies (n=1), case-control studies (n=1), cohort (n=11), and randomized control trials (n=14)) were identified, and their quality was assessed. Eighteen studies highlighted mainly positive results in preventive influence of soy bone fractures. Two papers reported a positive effect was observed in men with cancer. No significant association was found between soy intake and bone prevention fracture in eight distinct papers.

    Conclusion

    Intake of soy isoflavones can make a significant preventive effect on bone fracture; however, the results of some studies are controversial.  Therefore, it is necessary to survey more studies to identify the relationship between isoflavones and bone fracture.

    Keywords: Isoflavones, Bone, Fracture
  • Seyedeh-Masomeh Derakhshandeh-Rishehri, Milad Rajabzadeh-Dehkordi, Saeed Ghobadi, Shiva Faghih * Pages 173-188

    Oxidative stress is the leading cause of chronic disorders. The aim of the present study is to assess the effects of conjugated linoleic acid (CLA) supplements on oxidative stress biomarkers in adults.

    Methods

    PubMed, Web of Science, Google Scholar, ProQuest, Scopus, and Embase were searched up to December 2020. All clinical trials that evaluated the effect of CLA on malondialdehyde (MDA), GSH-peroxidase (GPX), and 8-IsoprostanesF2α (8-iso-PGF2α) were included.

    Results

    Twelve eligible studies were included in the meta-analysis. A significant increase was observed in 8-iso-PGF2α level (SMD=1.48 nmol/mmol of creatinine; 95% CI: 1.11 to 1.85) with low heterogeneity level (I2= 31.5%, and P=0.199). This effect was also significant in both subgroups of healthy and metabolic disorder individuals. Moreover, after Hartung-Knapp adjustment, the results remained significant. No significant changes were found in MDA (SMD=-0.34 µmol/l; 95% CI: -0.82 to 0.14) and GPX (SMD=0.31 U/gHb; 95% CI: -0.03 to 0.66) levels. However, after Hartung-Knapp adjustment, the results became significant for GPX level (SMD=0.31, 95% CI: 0.04 to 0.59).

    Conclusion

    CLA supplementation could significantly increase some markers of oxidative stress such as 8-iso-PGF2α level and GPX level, without any significant effect on MDA level.

    Keywords: Conjugated linoleic acid, Oxidative stress, Malondialdehyde, Isoprostanes