فصلنامه دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زابل
سال چهارم شماره 2 (تابستان 1391)

Adipose-derived cells are immature and transformed cells which can in specific conditions, play different roles such as providing a source of stem cells for treatment of damages and injuries. The aim of this study was to determine therapeutic effects of human adipose-derived stem cells on cerebral cortex injury in cerebral ischemic rats.

The present study included 30 male Wistar rats. The cases were divided into three groups. For experimental and sham groups, the right Carotid stroke was occlused by Common Carotid Artery occlusion (CCA) for 30 minutes in 100-150 g male Wistar rats. Seven days after surgery, the rats were divided into two groups to receive intravenously either BrdU positive human adipose stem cells [(2×105 cells in 1ml saline, n=10) as experimental group] or the same amount of saline [as sham group (n=10)]. There was also one group (control) without any surgery or injections. The animals were evaluated for 14 days to test movement disorders by limb placing and corner turn tests. Transplanted stem cells were detected by immunohistochemistry.

The results demonstrated that the injected ASCs were settled in the injured area of the brain and helped to improve the movement's disorders due to bleeding, in the experimental groups (P<0.05), which was better, compared to the sham group. The data also revealed that size of damaged region in brain of experimental group was decreased significantly.

It is concluded that the adipose stem cell's transplantation has a beneficial influence on brain tissue reparation after hypoxic ischemic cell's death, especially in the hypothalamic area and cortical region.

The Neonatal Jaundice is a common and benign disease. With early discharge, many newborns have to be readmitted to hospital for evaluation and treatment of hyperbilirubinemia. In these situations, the main concern is the prevention of development of kernicterus. The objective of the present study was to evaluate the correlation between Bilirubin, NRBC and Reticulocyte levels of umbilical cord blood with Neonatal Hyperbillirubinemia in Kosar Hospital of Qazvin. in this analytical-descriptive study, a representative sample of 74 healthy full-term newborns that were heavier than 2500 grams and were born in spring 2011, were investigated. Cord blood was taken from umbilical cord for analysis of NRBC, Reticulocyte and Bilirubin levels, then newborns were monitored in terms of developing jaundice by clinical and laboratory evaluations in the fifth day. The cord blood level of NRBC and Reticulocyte in icteric newborns which required phototherapy was significantly higher than non-icteric newborns. The sensitivity and specificity of NRBC that were more than 5.5% for prediction of jaundice development were 66% and 90%, respectively (p<0.000). The above findings for Reticulocyte percentage more than 6.5% were 73% and 60%, respectively, (p<0.001). The routine evaluation of Bilirubin level in umbilical cord is not as effective for screening and recognition of high risk of Neonates. Instead, cord NRBC and Reticulocyte levels could be used.

Oral diseases are one of the most prevalent human diseases, especially among the children and more than 99% of people suffer these diseases. Factors that are associated with promotion of effective behaviors have an important role in reducing these diseases. Associated factors with oral health behaviors among female primary students were investigated in the current study, in Zabol, based on the health belief model. In this descriptive-analytical study that was conducted in 1390, 287 female primary students of Zabol were randomly selected and studied. Data were collected with completing the questionnaire that was designed based on health belief model. justifiability was determined through expert panel and reliability by Cronbach`s alpha (N=30, =0.77). SPSS18 software was used for data analysis. According to results, the mean score of student`s behavior was 3.72 from 10 and approximately 30% of them performed the desired behaviors. Among studied variables in this model, there was a significant correlation between perceived barriers and self-efficacy with the behavior. Also the main source of student's information was their parents. Oral health behaviors in the studied population were poor. According to the results, for improving oral health behaviors by training programs in the students, some factors such as increasing self-efficacy, overcoming the obstacles and considering the role of parents are necessary.

Delivery before 37 weeks is called preterm labor. Preterm labor is one of the major problems in obstetrics, and the greatest cause of morbidity and mortality in the infants. This study was designed to compare the effects of oral Nifedipine and injectable magnesium sulfate for treatment of preterm labor in Ali-ebne-abitaleb hospital in zahdan, from 1384 to 1386. This randomized and clinical trial study was performed on 110 pregnant women who were hospitalized for suppression of preterm labor pain. The participants were divided into two groups, randomly. The pain being not suppressed by bed rest and Fluid therapy, in the first group Magnesium Sulfate infused injection was performed, and the second group were given oral Nifedipine. Uterine contractions were controlled by touching. Descriptive statistics, an independent T-test and Chi-square calculated by SPSS (11) were used for statistical analyses. There were no significant statistical differences between groups, regarding the age of pregnancy and mother's parity. The results showed equal labor pains (83.6%) controlled in both groups in the first 24 hours. Also, comparison of labor pains suppression in both groups did not show significant differences after 48 hours. Overall, side effects in magnesium-sulfate-treated group (54.5%) were more than Nifedipine-treated group (22%). Neonatal outcomes were similar in both groups. Regarding the equal results of this study, ease of consumption and related side effects depend on the specific case. We can use one of these two drugs for suppression of labor pains, alternatively. Nifedipine can be used in suppression of labor pains instead of magnesium sulfate patients who do not have low blood pressure.

diagnosis, treatment, reversion, consequences, side effects of treatment and recurrence of breast cancer lead to psychological reactions such as depression, anxiety and stress. These reactions can reduce quality of life in breast cancer patients by interference in function, control of symptom, making decisions about treatment, adherence to treatment regimens and social interaction. This research is based on correlation method. Statistical population was containing all women with breast cancer who had medical records in Imam Reza hospital of Kermanshah in 2010. Sample of research was 294 women with breast cancer that selected based on purposive sampling. Psychological distress assessed by DASS-21 and quality of life assessed by WHOQOL-BREF. Data were analyzed statistically by version 11/5 of SPSS software. Statistic data analysis was based on descriptive statistics, Pearson correlation, inter regression analysis. P < 0/05 was considered significant. Results showed that psychological distress has a significant negative relationship with quality of life (P < 0/05). Based on inter regression analysis fifteen, twenty four, and twenty four percent of the variance in the physical health was explained by depression, anxiety and stress respectively. Also sixteen, nine, and nineteen percent of the variance in the psychological health was explained by depression, anxiety, and stress respectively. In the other hand, four, five, and six percent of the variance in the social relationship was explained by depression, anxiety, and stress respectively. Finally, twenty one, twelve, and fifteen percent of the variance in the environment health was explained by depression, anxiety, and stress respectively. Therefore, stress was strongest predictor of physical health, psychological health and social relationship and depression was strongest predictor of environment health. It is concluded that in women with breast cancer, psychological distress, especially stress and depression have important roles in reduce of physical and psychological health. This research showed that stress and depression lead to dissatisfaction of women with breast cancer from their social relationships and circumstances of their life environment. Therefore, attention to psychological distress and it’s reduce should be consider as one of the essential priorities in psycho-medical interventions.

Topiramate is an anti-epilepsy drug and its Consumption during pregnancy may induce skeletal and craniofacial malformations. The aim of this study was to evaluate the protective effect of folic acid on the reduction of topiramate- induced anomalies in Balb/c mice. In this study, 72 Balb/c timed-pregnant mice were divided into 6 experimental and 2 control groups. Experimental groups I,II and III received daily oral gavages of topiramate (50,100 and 200 mg/kg, respectively) and experimental groups IV, V and VI received similar doses of topiramate with 3 mg/kg/day folic acid supplement by gavage route. Control negative and positive groups received normal saline and folic acid, respectively. Oral gavages were done during GD6-GD15. Gavage of folic acid was done from 10 days before pregnancy to day 15th of pregnancy. Dams underwent Cesarean section on GD18 and were investigated by microscopic tools, and after determination of weight and crown- rump length, external examination was done and fetuses were stained with Alizarin red S and Alcian blue staining. The mean weight and crown-rump length of the fetuses in three experimental groups I, II and III were significantly reduced compared with control groups (P < 0.05). Orofacial deformities such as mandibular hypoplasia and open mouth were detected in experimental groups I, II and III. A significant decrease was seen in the incidence of these deformities in fetuses of groups IV, V and VI that received folic acid-topiramate co-administrations. Findings of this study showed that using topiramate during pregnancy may induce fetus malformations and consumption of folic acid can reduce topiramate- induced birth defects.

All human beings deserve healthy aging. The elderly are one of the groups that require special interventions in improving the health promoting behaviors to decrease the disability onset and to prevent the disease outbreak and premature deaths. Therefore, this study has been conducted to determine the health promoting behavior in elderly people admitted to hospitals in Zahedan. This analytical and descriptive study included 300 elderly people who had admitted to hospitals in Zahedan. The patients were chosen based on the convenience sampling method and questionnaire's data were collected through interviews. For data analysis, descriptive statistics (frequency and percentage) and inferential statistics (Chi-square test) were used. Of 300 elderly studied, 12.6% has smoked and 0.3 % has consumed alcohol. 26.3% has done exercise regularly, 51.3% had low-salt diet and57.7% had low-fat diet. 97.7, 64, 56 and 54.3% of the study group haven’t used vegetables, fruit, dairy and the recommended meat respectively. 31.3% had done the general examinations, and 9.3% had vaccinated against influenza in the last year. There was a statistically significant relationship between the most of health promoting behaviors and education, rural and urban residency while there was no statistically significant relationship between the health promoting behaviors and gender. According to the obtained results, planning for training and development of health promoting behavior in elderly people is essential.