فهرست مطالب الهام اکبرزاده

Due to the importance of estrogen reduction during menopause and its relationship with NAFLD as well as the effect of exercise and calorie restriction on improving the risk factors for this disease, in this study the effect of aerobic training and calorie restriction on liver steatosis and hormonal changes in Postmenopausal Women with NAFLD was evaluated.

24 non-athlete women with type 1 non-alcoholic fatty liver (aged 53.00±2.77 years, BMI 29.64±1.38 Kg/m2) participated in this study. The Subjects were divided into 3 groups: aerobic training (EX: n=8), calorie restriction (CR: n=8) and combination (EX+CR: n=8). In the calorie restriction group, 25% of each subject’s daily energy requirement was reduced for 12 weeks. In the aerobic training group, 25% increase in energy expenditure through aerobic exercise was considered.

plasma estrogen and serum insulin levels in the calorie restriction group(-7.91%, -19.23%) and combined(-7.03%, -25.65%)decreased significantly(p < 0.05). Only in the combined group, the levels of cholesterol(-7.94%)and triglycerides(-9.58 %)showed a significant decrease(p < 0.05). There was no significant change in HDL levels in any of the groups after 12 weeks. all three groups significantly reduced the LDL levels(-2.41%, -1.54%, -2.27%),fasting glucose(-1.99%, -5.65,-6.99%),insulin resistance(-11.32%, -23.38%, -30.96%),and hepatic steatosis(-14.50%, -6.22% , -5.90%)(p <0.05).

aerobic exercise combined with calorie restriction can lead to more effective changes in improving lipid profile, and metabolic control, and aerobic exercise is more effective in maintaining estrogen and improving hepatic steatosis. Therefore it is recommended to use a combination of aerobic exercise along with calorie restriction in the treatment process.