محبوبه مهربانی نطنزی

Burn infections are one of the leading causes of death in the world. Antibiotic resistance is a major concern among the medical community. In this study, we investigated the effect of common probiotic strains on multidrug-resistant Pseudomonas aeruginosa strains.

Strains of Pseudomonas aeruginosa from burn wounds of patients were isolated. Then pathogens were biochemically identified and their antibiotic resistance pattern against imipenem, gentamycin, ciprofloxacin, tetracycline and chloramphenicol were examined. Susceptibility of multidrug-resistant pathogens to 5 commercial and 5 native strains of probiotics were investigated using disc diffusion method. The probiotic strain, with the highest anti-pathogen activity was tested either alone or in combination with five previously tested antibiotics.   

The Lactobacillus plantarum 299V strain showed the highest inhibitory effect against the antibiotic-resistant Pseudomonas aeruginosa pathogens compared to the other probiotic strains. In most isolates, probiotic alone, had a higher mean diameter of growth inhibition zone compared to the combination with antibiotics, except for tetracycline antibiotic, which is synergistic with probiotic bacteria and has the highest anti-pathogenic properties (P <0.001).

According to the results of this study, Lactobacillus plantarum can be used as an adjunct in the treatment of antibiotic-resistant bacterial infections in the treatment of burn wounds.

The common cause of stomtitis is the oral dandruff of candida albicans in the Microbial flora of the oral cavity of healthy young people. The base of acrylic dentures is usually made of the polymethacrilate resin. The various factors make it possible for the cavonisusion candida to be cooled in to these materials, which there are various protocols to prevent this. The probiotics may be among these factors.

In this study, discs of acrylic resins in different groups after exposure to Candida albicans were exposed to are solution including a probiotic bacteria L-rhamnosus GG ,a solution containing probiotic K12 streptococcus salivarius a sodium hypochlorite , nystatin solution, normal saline, then the number of candida albicans was counted and their comparison was made Statistical analysis was performed using ANOVA.

The results showed a significant decrease (p<0/001) in the number of C.adbicans in discriples in probiotic solution to normal saline solations. Also, the lowest number of C.adbicans sticking to discs plates in a solution Containing nystatin and sodium hypochlorite has been

According to the results of this study, probiotic Solutions can be used to reduce the number of C.alhicans adhearing to the removable denture base.

Periodontal diseases in smokers are 2.6 to 6 times higher than non-smokers and their response to treatment is much lower. Reducing levels of antioxidants and consequently increasing oxidative damage in the pathogenesis of periodontitis is effective. Regarding the importance of free radicals in the pathogenesis of periodontal diseases, the aim of this study was to investigate the effect of cigarette on the oxidative and antioxidant status of saliva in chronic periodontitis patients and compare it with healthy controls.

In this case-control study, 20 patients with chronic cigarette smoking periodontitis, 20 patients with non-smoking chronic periodontitis and 20 healthy individuals who had no history of periodontitis and smoking, were among those referring to dental clinics and clinics of Karaj were chosen. Uninstivated saliva was collected and salivary total antioxidant capacity was measured using a kit in saliva. Statistical analysis was performed using ANOVA.

Total antioxidant capacity of saliva in smoker periodontitis and non-smoker periodontitis was significantly (P <0.05) less than normal Persons.

Based on the results of this study, chronic periodontitis reduces the total antioxidant capacity of saliva, on the one hand, due to the increased production of oxidants in inflammatory responses to this disease, and, on the other hand, the presence of compounds such as nicotine cigarette that disturbs the chain Respiratory mitochondria and increased oxidants.