امیرحسین اسماعیلی

Traffic pollution is one of the most serious health problems in the world. Oxidative stress caused by free radicals leads to a wide range of cellular damage such as enzyme inactivation, lipid peroxidation, protein and lipoprotein oxidation and a variety of diseases. The aim of this study was to evaluation of oxidative stress parameters in the serum of urban drivers compared to suburban drivers with the impact of traffic pollutants.

The present research is a prospective Cohort study. The statistical population of the study was male drivers that referring to Ghaemshahr, Iran occupational medicine in 2019 to 2020. 45 drivers of urban vehicles exposed to traffic pollutants and 45 suburban drivers were selected as a control group by systematic probabilistic sampling to determine the oxidative (NO and MDA) and antioxidant (TAC, CAT) parameters in serum. Data were analyzed using chi-square and T-test in SPSS 22 software.

The data from this study showed that the mean of nitric oxide, total antioxidant capacity and catalase enzyme indexes in the group of drivers exposed to traffic pollutants were lower than the control group, while lipid peroxidation was higher in the group of drivers exposed to traffic pollutants compared to the drivers in the control group, which is significant at the level of statistical probability level of 1% (p <0.001).

The results of the research showed that oxidative stress caused by traffic Pollutants decreased the total antioxidant capacity (TAC) and increased oxidative conditions in the group of drivers exposed to traffic pollutants, which can threaten the health of these people.