فهرست مطالب alireza badiei

Hantzsch reaction is a popular procedure for the synthesis of dihydropyridines (DHPs) through the reaction of two equivalents of a β-ketoester with one equivalent of aldehyde in the presence of an ammonia source. The Hantzsch reaction of pyrazolone, aromatic aldehydes and ammonium acetate was studied in the presence of SBA-Pr-SO3H, as the catalyst, to gain tetrahydrodipyrazolopyridines. The high yield of products (80-95%) within a short reaction time (6-15 min) proves the efficiency of this methodology. Finally, molecular docking studies were used to show the binding mode of these compounds in the active site of 3-phosphoinositide-dependent kinase 1 (5OOT). Docking computations show the Gold Score value and the binding mode of resulting complexes. The synthesized compounds can bind to the receptor’s residues by forming hydrogen bonds and π interactions. The detailed analysis of the binding mode of the best-docked molecule exhibited a hydrogen bond between NH substituent and Tyr20. Moreover, π-π and π-cation interactions can be seen with the residues Tyr20 and Lys38, respectively.

Preparation of an efficient hybrid structure photocatalyst for photocatalytic decomposition has been considered a great option to develop renewable technologies for environmental remediation. Herein, ternary magnetic Fe3O4/GQD/g-C3N4 nanocomposite (FGC) was prepared using the ball mill method. Binary nanocomposites Fe3O4/g-C3N4 (F/CN) and GQD/g-C3N4 (G/CN) were prepared to compare photocatalytic activity with FGC. The performance of photocatalysts for degradation of rhodamine B (RhB) was studied. EDX results showed that Fe3O4, GQD and g-C3N4 nanoparticles (NPs) are uniformly distributed in the FGC. The FGC nanocomposite shows superparamagnetic behaviour with a saturation magnetization of 12 emu. g-1, which makes it favourable compound for magnetic separation procedure. Photocatalytic activity of FGC (100%) was much higher than those of the G/CN (88%) and F/CN (77%) photocatalysts. The superior activity of FGC compared to binary composites was attributed to broader absorption in the visible light band and greater suppression of electron-hole recombination. The photocatalytic degradation of RhB using FGC was consistent with pseudo-first-order kinetics. The reusability of FGC was examined for four runs and no noticeable decrease was observed with the same irradiation time for each run. Finally, it can be argued that FGC photocatalyst can be an efficient semiconductor for the degradation of organic dyes from wastewater.

In this study, the potential of SBA-15/di-urea nanoporous silica compound for the removal of Pb2+ and Cu2+ ions was investigated. The presence of organic groups in the silica framework of SBA-15/di-urea was demonstrated by the FT-IR spectrum. The functionalized product showed the BET surface area 518 m2/g and pore diameter 6.5 nm, based on adsorption-desorption of N2 at 77 K. SEM revealed a rod-shaped morphology, and the TEM image showed an ordered array of 2D hexagonal mesoporous SBA-15. The ions in the samples were identified by flame atomic absorption spectrometry. The effect of adsorbent amount, contact time, metal concentration, pH, and presence of other metals on removal efficiency has been studied. Simultaneous removal of Pb2+ and Cu2+ ions from 20 mL of the sample solution containing 60 μg of each ion were completely done at pH greater than 5.0 after stirring for 15 minutes. Langmuir, Freundlich, and Temkin adsorption isotherms were evaluated for both adsorbates and it was determined that the data fitted well with the Langmuir model (R2> 0.98). The maximum capacity of the adsorbent was found to be 147.0 ± 0.6 mg and 77.0 ± 0.5 mg of Pb2+ and Cu2+ ions/g SBA-15/di-urea, respectively. The lowest amount of 3M nitric acid for stripping the target species from adsorbent was determined as 20 mL. The application of this methodology for the real sample was tested by an Industrial wastewater sample.

In the past few years, scientists are looking for new methods to characterize materials and identify their features in natural media without any separation. The electric field is one of the most important parameters which affects the structure and changes all systems, including electron movement. The electric field affects all processes and transitions in systems that include electric charge. Electron-absorption (Stark) spectroscopy is a method to obtain absorption spectra that are investigated in the presence and absence of an electric field. The electric field makes changes in samples' dipole moment. These changes give much information about how different components approach each other and react, the type of interactions, and how they affect one another. We can predict the occurred processes in the reaction media with this type of information and use them in intermolecular interaction modeling. These spectroscopy methods' most essential usages are in the characterization and identifying the properties of polymers, proteins, nanoparticles, quantum dots, and optical devices' design.

Magnetic Fe3O4 nanoparticles coated with thiol functionalized mesoporous silica (TFMS) were prepared and usedas a novel adsorbent for Pb2+ and Ag+ removal. FTIR spectra confirmed the Fe3O4 nanoparticle cores coated with mesoporous silica and indicated the presence of thiol groups on the surface. XRD analyses showed that synthesized adsorbent has a face-centered cubic magnetite phase structure. The best removal results were obtained at pH=5-7 and a stirring time of 15 minutes. The lowest amount of 3M nitric acid for stripping the target species from adsorbent was 40 mL. The data was found to fit the Langmuir model, and the respective maximum capacities of the adsorbent for Pb2+ and Ag+ ionswas 1000.0 (±1.5) µg and 1111.0 (±1.2) µg of the target species per mg of the adsorbent. The developed adsorbent was successfully applied in wastewater samples.

In this research, pure Yttrium Aluminum Garnet (YAG, Y3Al5O12) nanostructures were synthesized through a two-step process by using chloride precursors in a solution of water–ethanol electrolyte with specific ratio. Also, the effect of cationic surfactant CTAB, on the size and the morphology of the prepared nanostructures were investigated. For the synthesis of YAG, a layer of hydroxide film was deposited on the surface of cathode via cathodic electrodeposition method and then, it was transformed to the final oxide product in the course of a thermal operation. X-Ray Diffraction (XRD) analysis was used for characterization of phase and crystal structure of prepared materials and also Fourier Transform Infra-Red spectroscopy (FTIR) was used for characterization of absorption bonds. Thermal behavior of deposited hydroxide during the thermal operation was studied by Differential Thermal Analysis and Thermal Gravimetric Analysis (DTA-TGA) technique. The morphology and particle size of obtained powder was determined by Scanning Electron Microscopy (SEM). The results of our studies showed that the cathodic electrodeposition method is a practical and very efficient method for preparation of YAG nanostructures and addition of a cationic surfactant like CTAB into the electrolyte during the electrochemical deposition can lead to the formation of smaller particles and also has an impressive effect on the homogeneity and narrower particles size distribution.

Researchers take a great interest in nanoparticles due to their unique properties and high level of performance. Yet, despite the functions of nanoparticles in various sciences and industries, their potential effects on human health especially fetal heart have not been fully investigated. The destructive effect of iron nanoparticles on the fetal heart is inevitable. Therefore, the aim of this study was to investigate the effect of iron oxide nanoparticles on fetal heart growth and development in vivo and in vitro on NMRI mice.

Materials and Methods: 

In this study, mice were divided into three groups: 1- Control: (without the effect of iron oxide), 2- Sham: (injection of solvent iron oxide and distilled water on the 9th day of pregnancy) 3- Treatment: (under the influence of different concentration of nano-iron oxide particles (10, 30, and 50 µg/kg body weight) on the 9th day of pregnancy). On day 16 of pregnancy, fetuses were taken out and their heart was removed (in vivo method) and analyzed by morphological, histological, and statistical criteria. As for in vitro method, pregnant mice were anesthetized on day 15. The embryos were removed from the body. Their hearts were separated and cultured in a culture medium containing a certain dose of iron oxide nanoparticles. Then, morphological and histological changes were examined.

Injection of iron nanoparticles at concentrations of 10, 30, and 50 g/kg caused a significant increase in fetal body weight and height. However, in the results of the examinations on the heart organs, no change in the diameter, weight, wall thickness of the ventricles and atria was observed both macroscopically and microscopically.

In the findings of our study, increase in body length and weight of fetuses can significantly indicate the possibility of increased cell division in the fetus and the ability of these nanoparticles to pass through the placenta and transfer from mother to fetus.

A mild procedure for the diastereoselective Diels-Alder reaction of methyl acrylate and cyclopentadiene was performed using modified silica with different concentrations of metal ions as Lewis acid support. According to the results, among the tested metal ions, cadmium ion supported on the silica was the best diastereoselective catalyst in this reaction.

In this study, the application of the Diels-Alder cycloaddition reactions between methyl acrylate and cyclopentadiene has been studied using a silica-supported catalyst with various concentrations of Zn2+ ion (Silica@Zn+2) as Lewis acid catalyst without using the solvent. The effective role of silanol groups in increasing stereoselectivities of products was also studied.

There is a huge scope for the removal of heavy metal ions from aqueous solutions. In this study, mesoporous silica materials, (MSMs), functionalized with (3-Mercaptopropyl) trimethoxysilane, (MPTS/MSMs), were prepared and used for adsorption of Pb(II) ions from aqueous solutions. The synthesis of MPTS/MSMs adsorbent was done using one-pot hydrothermal method by immobilizing 3-Mercaptopropyl trimethoxysilane onto mesoporous silica surface. The structure and properties of the adsorbent were explored using different techniques such as FT-IR, XRD, SEM, TEM, TGA, and N2 adsorption-desorption isotherms. The adsorption applicability of prepared nanostructure for removal of the Pb(II) ions from the aqueous solution was investigated and the results showed a good selectivity in the absorption of Pb(II) ions over other ions in aqueous solution. The effect of different parameters including the solution pH, Pb(II) concentration, sorbent amount, ion interfering effect, and the contact time onto the removal efficiency of the adsorbent was investigated systematically. The maximum adsorption efficiency (~ 97%) was found for the solutions with pH = 6, the best contact time was seen as 30 min for 50 mg L−1 of the analyte under the optimal conditions. The adsorbent was triumphantly used for the removal of Pb (II) ions from the three real water samples, including tap water, well water, and lake water with the removal efficiency of > 95%.

Multifunctional magnetic nanostructures were considered by different functional organic groups to use as a drug delivery arrangement in cancer therapy. The modulating nonmagnetic core-shell, yolk-shell structures, and the MRI-monitored drug release cells were applied in cancer therapy. Furthermore, magneto-fluorescent nanocarriers with fluorescent and superparamagnetic features were used in bioimaging and MRI, respectively.

Nowadays, provision of sanitary water is one of the main concerns of the world society, and heavy metals are one of the most important pollutants in water resources. Heavy metals, including copper, can enter the food chain and the body of living organisms and can affect humans through toxic and carcinogenic effects. Therefore, in this study, nanoporous SBA-15 functionalized with di and tetra carboxylic acid was synthesized and used for remove copper ions from aqueous solutions. The adsorbents were characterized by scanning electron microscopy, N2 adsorption-desorption measurements and infrared spectroscopy for investigation of porosity and functional groups of mesoporous silica. Flame atomic absorption spectroscopy was used for determination of ions. Effective parameters on removal process including amount of adsorbent, contact time, pH of solution and presence of other metal ions in the medium, were evaluated and optimized. The best removal efficiency with di and tetra carboxylic acid functionalized SBA-15 was obtained at pH>5 with 10 mg of adsorbent in the stirring time of 15 minutes. The recovery of copper from adsorbents was done with 20 ml solution of nitric acid (3 mol/L). Langmuir and Freundlich adsorption isotherms were evaluated for both adsorbents. According to the Langmuier model, the maximum adsorption capacity of 232.56 and 93.46 mg of copper per gram of adsorbent and correlation coefficients (R2) of 0.857 and 0.9688 for di and tetra carboxylic acid functionalized SBA-15 were obtained, respectively. But, the correlation coefficients (R2) obtained from the fitting of the data using the Friendlich isotherm were 0.991 and 0.972 for di and tetra carboxylic acid functionalized SBA-15 silicas, respectively, which indicates that this model is suitable to explaining the behavior of copper adsorption on both adsorbents. Finally, the removal of copper from real wastewater samples was performed. The results indicate that nanoporous SBA-15 silicas functionalized with di and tetra carboxylic acid are desirable adsorbents for copper ions removal.

In this research, pyrophyllite phase transfer to tobermorite group and sodic to calcic zeolites was investigated in presence of NaOH and CaCl2 solutions. The experiments were carried out in three separate stages under constant hydrothermal conditions (temperature 150 °C, time 72 h) in the Teflon-lined autoclaves. The chemical composition of the initial sample was determined by XRF. Morphology and mineralogy of samples were characterized by SEM and XRD, respectively. The results showed that leucite and sodic zeolites (analcime, sodalite) were formed at variable concentration of NaOH (1–8 mol/l). The calcic zeolite was not synthesized in the presence of Na+ (1.5–2.5 mol/l) and Ca+2 (0.25-1 mol/l), but riversideite, hibschite, halite, hydroxycancrinite and trikalsilite were detected. Riversideite (a member of tobermorite group) and hibschite (a type of hydrogrossular) were formed at highest concentration of Ca+2 (1 mol/l), and halite was produced as a main product at lowest concentration of Ca+2 (0.25 mol/l). The concentration of Ca+2 and Na/Ca ratio are the main factors in the synthesis of these products.

Efficient functionalization of Fumed silica by sulfonamides via copper-catalyzed Huisgen 1,3-dipolar cycloaddition (Click) reaction has been reported. Functionalization of Fumed silica by 3-azidopropyl groups leads to the formation of azide moiety as building blocks for Click reaction. Propargylation of three commercial sulfonamides (sulfadiazine, sulfadimidine, and sulfaquinoxaline), with propargyl bromide, leads to the formation of another building block for Click reaction. The Click reaction was catalyzed by freshly prepared Copper(I) iodide in DMF at room temperature after 72 hours. Antimicrobial activities of sulfonamides functionalized Fumed silica were measured against Staphylococcus aureus as gram-positive bacteria and Escherichia coli as gram-negative bacteria and checked by their Zeta potentials.

In this study, thiol-functionalized nanostructure silica type MCM-41 was successfully prepared via the facile one-pot hydrothermal method with low amounts of the directing agent. The mesoporous silica indicated a remarkable adsorption behavior toward Pb(II) ions without any interference of the competing ions. The main experimental variables affecting removal efficiency of the adsorbent were examined, and the optimized conditions were achieved as to be 6, 50 mg, and 30 min for solution pH, the adsorbent dosage, and contact time, respectively. The adsorbent was triumphantly used for the removal of Pb (II) ion from real water samples with a notable removal efficiency as 95%. The concentrations of the competitive ions in the solution were about 10 to 100 times more than Pb (II) ions. The results show that other ions had no interfering effect on the removal efficiency of Pb (II) ions. It means that SH-SiO2 has excellent selectivity for Pb (II) ions and is an appropriate candidate for removing Pb (II) ions from the real samples.

In this work, polyamidoamine dendrimer G(1.5) supported on SBA-15 nanoporous is used as a novel sorbent for extraction and determination of Pb2+ and Cu2+ ions from environmental water specimens utilizing flame atomic absorption spectrometry. FTIR spectrum and thermal analysis were used to represent the existence of dendrimer groups in the silica framework. The various parameters like pH, concentration of eluent, extraction time, interfering ions on extraction efficiency were studied. Pb2+ and Cu2+ ions were completely extracted at pH= 5-8 after stirring for 5 minutes. The minimum quantity of acid for stripping the ions from SBA- G1.5 was examined and the pre-concentration factor of the technique was 233 for both of ions. Under the optimized conditions the linearity of the technique was within 10-40 ng mL−1 Pb2+ and 2-20 ng mL−1 Cu2+. Detection limits for Pb2+ and Cu2+ were 5.0 and 1.2 ng mL-1 and the relative standard deviations (RSD, %, C=15 ng mL-1, n=5) were 2.9 % and 2.1 %, respectively. There was a good consistency between the measured and added amount of Pb2+ and Cu2+ in spiked distilled water which shows good accuracy of the method. Capability of the method in real sample was tested in various water samples.

In this study, N-methyl-N'propyltrimethoxysilylimidazoliummodified LUS-1 and MCM-48 nonoporous materials were prepared and employed as adsorbent for removing Reactive Blue-19 from aqueous solutions.LUS-1 and MCM-48 were made based on the previous procedure and modified with N-methyl-N'propyltrimethoxysilylimidazolium chloride. XRD analyses did not show any lattice alteration between modified and unmodified adsorbents. A hexagonal mesophase structure with the P6mm symmetry for LUS-1 and IM-LUS-1, and a cubic Ia3d space group for MCM-48 and IM-MCM-48 were observed. UV/Vis spectrophotometry was used to determine of the dye concentration in the solution. Batch studies were conducted in order to find the optimum adsorption conditions and investigation of different empirical parameters like the pH impact, contact time, the amount of adsorbent, and concentration of dye on adsorption process. The best dye removal efficiency of the adsorbents were more than 93% at pH= 3.0-7.0 after about 3 min for IM-LUS-1 and after 30 min for IM-MCM-48. RB-19 dye was desorbed from both of the adsorbents with 10 mL of sodium hydroxide 2 M during 5 min. There was well match between the data and the Langmuir model with maximum adsorption capacities 476.2 mg/g IM-LUS-1 and 277.8 mg/g IM-MCM-48. The reusability of the sorbents were higher than 4 cycles. In addition, removal percent of RB-19 dye from 50 mL of real textile wastewater with 20 mg of IM-LUS-1 and IM-MCM-48 were 93.0 (± 0.6) and 90.2 (± 0.7), respectively. The results showed that this method might be appropriate for removing the pollutant dyes from textile wastewater.

Breast cancer is a devastating disease related to women. The anticancer properties of 8-hydroxyquinoline (8HQ) and the increasing use of graphene oxide (GO), as a drug delivery system with anti-cancerous properties, led us to investigate the toxicity and apoptosis-induction capability of 8HQ-coated GO on breast cancer cells compared with normal breast cells. Breast cancer (MCF-7) and normal breast (MCF-10) cell lines were treated with several doses of 8-HQ-coated GO for 12, 24, and 48 hr. The toxicity of the nanocomposite was measured using MTT assay and the effect of the nanocomposite on cell apoptosis was determined by examining the expression of P53, P21, Bax, and BCL2 genes, as well as Annexin-V /PI apoptosis assay. There were significantly increased cell deaths in nanocomposite-treated MCF-7 breast cancer cells, compared with treated normal breast cells. Significantly increased expression of P53, P21, and Bax genes and reduced expression of BCL2 gene were found in the treated breast cancer cell line compared with the normal cell line. Annexin-V/PI assay also illustrated significant induction of apoptosis in MCF-7 following nanocomposite treatment. Overall, 8HQ-coated GO has toxicity for breast cancer cell lines and one of the mechanisms through which this nanocomposite can induce cell death is the induction of apoptosis. With complementary  in vitro and in vivo studies, this nanocomposite can be suggested as a nano-drug with anti-cancer properties.

Ordered nanoporous silica such as SBA-15 has a great potential for application in controlled drug release systems. Chemical modification of the silanol groups of SBA-15 allows better control over drug loading and release. Therefore, tris(2-aminoethyl) amine-functionalized mesoporous silica SBA-15 was evaluated as a potential carrier for the delivery of citalopram.

Tris (2-aminoethyl) amine-functionalized SBA-15 was synthesized and characterized by various methods. Citalopram was loaded on the functionalized SBA-15 and drug release into simulated body fluid (SBF) solution and phosphate buffers was investigated.

The optimal condition for loading of the citalopram was obtained at pH = 9 after stirring for 5 minutes. The release profile of citalopram was monitored in phosphate buffers with three different pH values of 5, 7, and 8. A faster release rate at lower pH value was observed, suggesting a weaker interaction because of the protonation of the amino group of the functionalized SBA15. The average release rate of citalopram from each gram of functionalized SBA-15 was 12 µg h-1 in the SBF.

The results showed that loading amount and release rate of citalopram depended on pH value and the release process showed a very slow release pattern. Therefore, tris (2-aminoethyl) amine-functionalized SBA-15 is a suitable carrier for controlled release of citalopram and has a great potential for disease therapy.

The acidic agent (SO3H) was stabilized on the silica coated Fe3O4 magnetic nanoparticles to produce Fe3O4@SiO2@Pr-SO3H, as a heterogeneous acidic catalyst, was designed, and then fully studied and characterized by FT-IR, XRD, TGA, DTA, TEM, and SEM analysis. Subsequently, the catalytic activity of Fe3O4@SiO2@PrSO3H was investigated by the one-pot four- component condensation reaction between 1,3-indandione, aromatic aldehydes, acetophenone or propiophenone and ammonium acetate under the solvent-free condition at 80 ℃. The main advantages of this magnetic and heterogeneous acidic catalyst are high product yields, being environmentally benign, short reaction times, and easily separated from the reaction mixture using an external magnet.

In this study, the potential of 8-Hydroxyquinoline grafted SBA-15 to extract of Cu2+ cations from aqueous solutions was investigated. SBA-15 nanoporous silica was chemically grafted with 8-Hydroxyquinoline groupsaccording to the procedure in the literature. The presence of organic groups in the silica framework was demonstrated by FTIR spectrum. The grafted product showed the BET surface area 458 m2g-1 and pore diameter 54 ºA, based on adsorption-desorption of N2 at 77 ºK.. Flame atomic absorption spectrometry was used to determination of the ions concentration in the recovery and sample solution. The effects of several variables (amount of adsorbent, stirring time, pH and the presence of other metals in the medium) were studied. Cu2+ ions were completely extracted at pH= 4.5-7 after stirring for 15 minutes. The maximum capacity of the adsorbent was found to be 31.25 mg of Cu2+ per each gram of 8-Hydroxyquinoline grafted SBA-15. The minimum amount of acid for stripping of ions from grafted SBA-15 was tested and the preconcentration factor of the method was found 50. Finally, the proposed method was successfully applied as a new solid extractor to preconcentration and determination of trace amounts of Cu2+ ions in spiked distilled and tap water samples.

In this study, Bis (2-hydroxyethyl)amine functionalized mesoporous SBA-15 was synthesized for utilization in amoxicillin drug-delivery. Amoxicillin could absorb on the prepared functionalized SBA-15.  A solution of amoxicillin in a suitable solvent was used for this purpose. Amoxicillin molecules release from the matrix into a simulated body fluid (SBF) solution, and phosphate buffers were studied. UV-Vis spectrophotometric method was chosen for amoxicillin determination. Thermogravimetric analysis (TGA), scanning electron microscopy (SEM), nitrogen adsorption–desorption, and powder X-ray diffraction (XRD) technique were applied for characterization of the synthesized materials. The best loading of amoxicillin was done at pH 8.5 after stirring for 30 minutes. The results showed that, at lower pH, releasing of the drug was done faster than it at higher pH. Also, the average release rate of amoxicillin in the body fluid samples that were simulated was about 7 µg h-1. A highly slow release pattern was observed. The proposed material can be used for enhancing the medical impact of amoxicillin and carrying amoxicillin.

The present work focuses on the synthesis and application of imine-modified silica-coated magnetic (IM-SCM) nanoparticles. The X-ray diffraction (XRD) tests indicated the presence of highly crystalline cubic spinel magnetite both before and after coating with the silica. The FTIR spectra also proved the successful surface coating and imine-modification of the Fe3O4 nanoparticles. Further investigations were performed to examine the capability of the modified IM-SCM nanoparticles for simultaneous removal of Ag+ and Cu2+ from the water samples. Atomic absorption spectrometry was used for ion determination. The best operating conditions for removing the target ions were a pH=5-9 and a stirring time=30 min. Only 20 mL of 3M nitric acid was used for stripping the ions using the IM-SCM nanoparticles. The resulting data were found to fit well with the Langmuir model, and the maximum capacity of the adsorbent was determined to be 270.3 (± 1.4) mg and 256.4 (± 0.9) mg of Ag+ and Cu2+ /g of IM-SCM, respectively. The adsorbent was successfully used for simultaneously removing the target ions from the wastewater samples.

Organic-inorganic hybrid mesoporous materials such as amino functionalized silica (SBA-Pr-NH2) have received considerable attention due to their basic catalytic applications and adsorption functions. In this work, we investigated the efficient role of SBA-Pr-NH2 as a heterogeneous nano catalyst in the synthesis of 9,10-diaryl-7H-benzo[d,e]imidazo[2,1-a]isoquinolin-7-one derivatives. Application of SBA-Pr-NH2 as an eco-friendly and reusable catalyst resulted in reducing reaction time and temperature in this method. The preparation method was developed using a green one-pot three-component reaction of acenaphthoquinone, benzils and ammonium acetate under solvent-free condition. Besides, the synthesis of benzil derivatives as starting material was carried out. The new compounds were characterized by IR, mass, and NMR spectroscopy. The significant merits of this protocol are its simplicity, short reaction times, low reaction temperature, catalyst reusability, and non-chromatographic purification of products. Also, imidazole and benzimidazole moieties represent significant substructures of a wide variety of bioactive compounds and also significant structural motifs in biological systems, natural products, and drugs.

In this study, highly ordered mesoporous silica material (SBA-15) functionalized with Diethyl 2 - (9 -fluorenyl) malonate as a flourophore is reported. The anchoring of flourophores to the hydroxyl group on SBA-15 surface was done with post synthesis method. The obtained materials were characterized by small and wide angle X-ray diffraction, N2 adsorption–desorption, Fourier transform infrared spectroscopy and thermogravimetric analysis that indicate the successful immobilization of Diethyl 2 - (9 -fluorenyl) malonate on the surface of mesoporous silica. This organic–inorganic hybrid displayed highly selective and sensitive to Fe3+ ion over other cations such as Mg2+, Cr3+, Co2+, Ni2+, Cu2+, Hg2+ and Zn2+. Turn-off photoluminescence of this material was remarkably observed for iron ions in comparing of the other cations. A good linearity between the fluorescence intensity of the prepared material and the concentration of Fe3+ ion is constructed, which enables this martial as a fluorescence chemo sensor for detecting the Fe3+ ion with a suitable detection limit.