hadis mohammadi

Glioblastoma is one of the most malignant brain tumors, which is also known as primary neuroepithelial tumors. Glioblastoma malignant tumors include 20-40% of brain tumors. The LMO1 gene is located at position 11P15.4 and is introduced as an oncogene in some cancers. This study was conducted for the first time in Iran to identify and investigate the relationship between LMO1 gene mutations and glioblastoma.methodIn this research, the Touchdown PCR technique and DNA sequencing method were used in 35 blood samples of people with glioblastoma multiforme and 40 control samples. Bioinformatics analyses were also performed to investigate the pathogenic effect of nucleotide changes in this gene.

In this study, four point mutations were identified, of which two of the new mutations were misense and led to amino acid changes in one of the important domains of the protein (p.M135K and p.N148H), which indicates their potential pathogenicity. Our results of bioinformatics databases predicted that both of these mutations affect protein function, such that they can disrupt this domain and impair its function. Also, a nucleotide change was observed in the 3'UTR region of this gene (c.*74A>G), which is located at the binding site of two regulatory miRNAs and is expected to disrupt the binding of these miRNAs to the target sequence.

These findings predict that any mutations in the LIM-sensitive domains in the LMO1 gene are significantly related to the pathogenesis of glioblastoma and most likely have a significant impact on the function of this transcriptional cofactor.

The issue of soil contamination with petroleum compounds in Iran, a country renowned for its abundant oil reservoirs, presents a formidable challenge. The infiltration of oil pollutants in oil exploration sites results in soil contamination with hydrocarbons. The development of construction projects in oil-rich areas and the leakage of oil pollutants, the implementation of such projects requires sufficient knowledge of the geotechnical characteristics of oil contaminated soils. The estimation of soil dynamic parameters has a decisive role in the analysis of the structures and stress-strain behavior of soils. In this research, clay soil with highly plastic properties and different amounts (0, 2, 4, 6, 8, 10, 12, 14%) of Kermanshah refinery crude oil were used as hydrocarbon pollutants. The analysis of XRD, FESEM, EDAX and BET were used to characterize the mineral and morphology of the soil, and the results showed that the clay soil mineral was of kaolinite type. The results of the Atterberg limit test on clean and contaminated soil samples showed that with increasing pollution, the plastic limit and liquid limit decrease, and the plastic index decreases up to 10% of pollution and then increases. According on the compaction test, porosity ratio and the optimum moisture content of clean and contaminated samples obtained. The results showed that the maximum dry density of soil is equal to 1.61 gr/cm3, which is created in the clay sample with 12% contamination. Shear wave velocity and maximum shear modulus (Gmax) of clean and contaminated clay samples prepared with maximum dry density, in the range of 100 to 400 KPa confining pressure and frequency of 5 to 20 kHz, were measured by a bender element device. The graph of changes in shear wave velocity according to the porosity ratio for clay with different percentages of oil contamination showed that, with the increase of porosity, the shear wave velocity has decreasing trend. The results showed that the highest shear wave velocity and maximum shear modulus were observed in clay with 12% contamination in condition of 300 KPa confining pressure and 20 kHz frequency obtained 320 m/s and 512 MPa, respectively, Also with the increase of confining pressure and frequency, the shear wave velocity increases.

The purpose of the present study was to compare the mental Toughness, grit and motivational differences among individual and team athletes.

The present study is a descriptive post-event study with a causal-comparative design according to the purpose of the applied studies and in terms of the nature of the subject. The statistical population of the study included all athletes in Gorgan in individual and team disciplines. Research samples were accessible and selected by stepwise method. The research sample consisted of 116 people including 57 team athletes and 59 individual athletes who were selected by available sampling method and stage. Platter’s sports motivation questionnaire, abortive mental toughness and Duckworth steadfastness questionnaire were used to collect data.

Data analysis was performed by one-way analysis of variance. The results showed that individual athletes are steadfast than athletes in the lower level. Subjective hardiness and components of assurance, stability and control of individual athletes are lower than team athletes. Also, the amount of motivation and components of internal motivation, mixing regulation and self-regulating individual athletes are less than team athletes.

Therefore, it can be concluded that individual athletes are steadfast, mentally stiff and motivational differences are lower than team-mates athletes.

Proton exchange membrane fuel cells (PEMFC) have gained more attention as promising successors to fossil fuels due to their high efficiency and power density, low operating temperature, and no need for maintenance. In this research, first, the cell performance is investigated based on the step changes of current density using the Nernst equation and the governing equations of the fuel cell. Then, an equivalent electrical circuit model considering the effects of current density, temperature, and pressure on the fuel cell performance is presented. MATLAB software is utilized to solve governing equations of the cell. Comparison of the model results with experimental data shows that the model’s performance at low current densities is very well in line with the experimental results (with an error of less than 3.62%). Also, the proposed model shows an acceptable estimate (with an error of about 17.66%) of the cell performance in the whole range of simulated current densities (0 to 0.6 A/cm2). Finally, the effect of operating temperature and anode and cathode pressures on the fuel cell’s performance is investigated and shown that the cell voltage increases by increasing these parameters which, implies their constructive effect on the cell performance.

Non-alcoholic fatty liver disease (NAFLD) is associated with such symptoms as steatosis, fibrosis, and liver cirrhosis. Kelussia has attracted assiduous attention due to its protective effects on the liver. The PNPLA3 gene is mainly expressed in the liver and plays a major role in the degradation rate of hepatic triglycerides. Therefore, the present study aimed to assess the effect of Kelussia extract on PNPLA3 gene expression in rats with fatty liver and healthy rats.

This experimental study was conducted on 24 male Wistar rats in the control group (no treatment), obese group (which received a high-fat diet), treatment group 1 (which received a high-fat diet with Kelussia extract 400 mg/kg) and treatment group 2 (a high-fat diet with Kelussia extract 800 mg/kg) for six weeks. Blood samples were taken from rats and the factors of (LDL, HDL, Cholesterol, Triglyceride, and fasting sugar) were measured. After sampling the rat liver, the effect of Kelussia on PNPLA3 gene expression was investigated using the Real-time reverse transcription-polymerase chain reaction (RT-PCR) technique and analyzed in SPSS software (version 22).

Based on the results, Kelussia extract at a dose of 800 mg/kg resulted in a more dramatic decrease in PNPLA3 gene expression in rats with fatty liver, compared to a dose of 400 mg /kg, and this reduction was statistically significant, compared to the fatty liver group (P<0.05). The results of biochemical tests confirmed liver improvement in the rats treated with Kelussia extract at a dose of 800 mg/kg.

It can be said that Kelussia had a beneficial effect on the reduction of blood lipids; moreover, it reduces the accumulation of triglycerides in the liver and improves the tissue structure of the liver by reducing the expression of PNPLA3 gene; therefore, with more studies, it can be considered a supplement to reduce blood lipids.

Medication errors can be a threat to the safety of patients. Preventing medication errors requires reporting and investigating such errors. The present study was conducted with the purpose of investigating medication errors in educational health centers of Kermanshah. The present research is an applied، descriptive-analytical study and is done as a survey. Error Report of Ministry of Health and Medical Education was used for data collection. The population of the study included all the personnel (nurses، doctors، paramedics) of educational health centers of Kermanshah. Among them، those who reported the committed errors were selected as the sample of the study. The data analysis was done using descriptive statistics and Chi 2 Test using SPSS version 18. The findings of the study showed that most errors were related to not using medication properly، the least number of errors were related to improper dose، and the majority of errors occurred in the morning. The most frequent reason for errors was staff negligence and the least frequent was the lack of knowledge. The health care system should create an environment for detecting and reporting errors by the personnel، recognizing related factors causing errors، training the personnel and create a good working environment and standard workload.

the goals of HRM system in Naja touched by organization strategic goals which itself conformed with national defense strategies and establishing security in society. The research method was library and documentary review. At first the authors review previous researches about strategic human resources management in military organizations, then define initial conception and in second section they surveyed the different functions of strategic HRM in organizations and affiliated strategies. In section 3, the authors explain strategic HRM in military organizations. The findings indicate that collecting, executing and evaluating any of functional human resources strategies should be done according to futuristic view and in a some way which arised to more organization flexibility, increasing job prestige for employees and organization feeling job satisfaction, increasing employees commitment, subjugation, increasing employees militarization and motivating.