kazerani

To evaluate drought tolerance in rice recombinant inbred lines obtained from a cross between two cultivars of Ahlami-Tarom (tolerant) and Sepidrood (susceptible), a field experiment was conducted in spring 2016 in the research farm of Gonbad Kavous University. One hundered sixteen genotypes were studied using randomized complete block design with three replications in two environments (drought stress and non-stress conditions). MP, GMP, STI, RDY, HM, K1STI and K2STI indices had high correlations with grain yield under the two environments (drought stress and non-stress), therefore were identified as suitable indices for selecting drought-tolerant lines. A biplot analysis perfermed based on the first and second components of principle component analysis showed that lines No. 12, 112, and 113 were the most tolerant, and lines No. 43, 50, 64, and 89 were sensitive genotypes. Moreover, biplot also identified SNPI and SSPI suitable for identifying tolerant genotypes to drought stress. Grouping of lines based on 17 drought tolerantce indices and grain yield in the stress and non-stress conditions was performed by cluster analysis using Ward method, and four clusters were formed. The second and fourth clusters, with the highest and lowest K2STI, included the most tolerant and most sensitive genotypes to drought stress, respectively. Overall, according to the biplot and cluster analyses, lines No. 112 and 64 were identified as the most tolerant and most sensitive genotypes, respectively. Grain yield of line No. 112, in the drought stress and non-stress conditions was 5190 and 6640 kgha-1, respectively. However, grain yield of line No. 64, in the drought stress and non-stress conditions were 1640 and 2240 kgha-1, respectively.

Ischemic heart disease is the most prevalent cause of mortality in current populations. In recent years, many researchers have focused on plants to discover new natural therapeutic agents. The aim of this study was to evaluate the antiarrhythmic effect of the ethanolic extract of pomegranate mesocarp on rat isolated heart following myocardial ischemia and reperfusion. The hearts from Wistar rats were removed under deep anesthesia and were studied using Langendorff apparatus. The control and the test animals, in groups of 10, were gavaged with distilled water or the ethanol extract of pomegranate juice (200 mg/kg), respectively, daily for 3 weeks. At the end of the experimental period, the isolated hearts of the animals were studied. After 30 min stabilization, all hearts experienced 30 min global ischemia followed by 90 min reperfusion. Cardiac arrhythmias including single, salvo, ventricular tachycardia (VT), and ventricular fibrillation (VF) were characterized according to the guidelines of Lambeth Convention. The ethanolic extract of pomegranate mesocarp caused a remarkable significant reduction in all kinds of arrhythmias including single, salvo, ventricular tachycardia, and ventricular fibrillation. The results of this research suggest promising protective effects for the ethanolic extract of pomegranate mesocarp against ischemia and reperfusion induced arrhythmias in isolated rat heart.

As for the main role of the back of the book index (BOB Index) in retrieving the concept of a book, the aim of this study is to evaluate the BOB indexes of Persian medical books published from 1389 to 1393 according to ISO 999-1996.
This study is a descriptive survey. The research population consisted of all first-published medical printed books in the mentioned period from which 227 titles were selected randomly by means of Cochran's sample size formula. The data collection tool was a checklist based on ISO 999-1996. Descriptive statistics was employed to analyze the data using SPSS tool.
It was showm that only 3.75 percent of the books has BOB index. The highest frequency belongs to simple (73.6%) and fundamental (93.8%) indexes. In terms of content and coverage, on the one hand, and index level, on the other, the highest proportion belongs to subject index (87.24%) and single-level indexes (73.56%), respectively. The maximum compliance with the criteria related to the content and organization belongs to those of singular and plural with frequency of 223 (98.23). Also the highest rate of compliance with the criteria related to presentation and entry setting is the alphabetic order with the frequency of 225 (99.11%) and the lowest compliance belongs to the observation of indentions (6.6%). The mean compliance with ISO in books under study is 49.3%.
It is necessary that publishers of medical books pay attention to BOB index and, in this regard, “Ministry of Culture and Islamic Guidance” and “National Library of Iran” should develop appropriate programs and policies.

Reduced Beam Section (RBS) and Drilled Beam Section (DBS) are seismic moment resistant frame connections, introduced after 1994 Northridge earthquake. RBS connection has been tested under cyclic loading and showed acceptable performance. In this paper, seismic behavior of Drilled Beam Section (DBS) connection is studied numerically using finite element method. A drilled beam section of a cantilever H-beam has been subjected to cyclic loading at its free end and studied for its optimal shapes. 62 samples of DBS connections have been modeled and studied under cyclic and pushover loadings. Based on the results obtained in this research, the connection shows its positive seismic behavior if the biggest hole is near the column face and its diameter decreases as the holes move away from the column face. In this research the effects of dimensions, position and number of holes are investigated using Von Mises stress and elastic strain criteria under cyclic and monotonic loadings. In this drilled beam the smaller holes shift plastic hinges out of the connection zone.

Beam connections with reduced drilled section and slotted web have been presented after the Northridge earthquake (1994). Their new geometrical shapes have been resulted in weakening of beams and subsequently the bette rperformance of connections in the earthquakes. In this research, the advantages of both connections, mentioned above, have been studied in the Slotted Web Drilled Flange (SWDF) composite connections. Accordingly, the effects of different parameters of slot such as length, width and end hole dimension have been assessed as well. Based on the results obtained in this research,energy dissipation is reduced due to the increase of length of slot web in the SWDF connection, exceeded the values recommended in the codes. Besides, the stability of hysteresis curve decreases because of increasing in the width and end hole diameter of web slot.

Since stimulated telomerase activity provides nearly all of human malignancies including acute promyelocytic leukemia (APL) with unlimited proliferative potential، targeting telomerase seems to be an effective approach in cancer treatment. In this regard، BIBR1532، a small-molecule inhibitor of telomerase، has been shown to increase the therapeutic window of current chemotherapeutic regimens. This study was aimed to investigate the effects of BIBR1532 on cell proliferation as well as transcriptional alteration of hTERT (the catalytic subunit of telomerase). NB4 leukemic cells were treated with various concentrations of BIBR1532 and succeeding trypan blue exclusion assay، BrdU cell proliferation assay، and quantitative real-time PCR were applied to investigate cell viability index، cell proliferation and time-dependent alteration of hTERT mRNA levels. BIBR1532 decreased cell viability index and exerted an antiproliferative effect against NB4 leukemic cells; we found that exposing cells with BIBR1532 at 30، 60 and 90 μM for 72 h inhibited DNA synthesis rate by 24، 45 and 70%، respectively. Furthermore، transcriptional suppression of hTERT was found upon NB4 treatment by BIBR1532 in a time- and dose-dependent manner. Based on the short telomere length and high terlomerase activity in APL as well as antiproliferative effect of BIBR1532 against NB4 cells، anti-telomerase-based therapy might be regarded as a successful strategy in APL therapy.

Rosa damascena has been traditionally used as an herbal medicine for different therapeutic purposes. In order to preliminarily study the probable toxic effects of the plant، its infusion was orally administered to 5 groups of 5 dogs at doses 0. 5-8 times that of human use in traditional medicine (90-1440 mg/kg/d) for 10 successive days. The dogs in the control group (n=4) received placebo. Serum levels of urea، creatinine، alkaline phosphatase (ALP)، alanine aminotransferase (ALT)، bilirubin، albumin and protein weremeasured in all experimental groups at days 0، 1، 3، 7 and 10. Except for a transient increase in bilirubin levels (day 3) and a rise in serum ALT at day 10، both with the highest dose of the treatment، there were no statistical differences between different experimental groups compared to the control. The results suggest minimal nephrotoxic or hepatotoxic effects for the infusion of R. damascena، however، the medication may be hepatotoxic at extraordinary high doses.

Introduction & Cardiovascular diseases are the main cause of death in all countries in the recent century and congestive heart failure (CHF) is the reason of death in most pa-tients. The most common causes of CHF are ischemic heart disease، myopathies، valvular disease and hypertension. Mortality reduction is the aim in CHF treatment. Combination of glucose-insulin-potassium (GIK) has been used in the treatment of acute coronary syndrome and chronic CHF for two decades and different results reported. The current study performed to evaluate the efficacy of GIK to accelerate resolving signs and symptoms in patients with acute CHF. NT. pro BNP and H. s CRP are two components which increase in acute CHF and decrease after treatment. These parameters were evaluated in our clinical trial study. 50 patients admitted with the diagnosis of acute CHF and EF<40% were divided in two groups and the case group received GIK and control group placebo (half saline). Both groups received the classic treatment of CHF and the above mentioned parameters were measured in the first hour and third and fifth day. Appropriate reduction in both parameters، which means good result in treatment، was observed in both groups but without statistical significant difference. GIK has been used with good results in acute MI and chronic heart failure، but in order to prove better efficacy and decrease in mortality in acute CHF more research is needed.

premenstrual syndrome (PMS) is a psycho-somatic disorder that occurs in luteal phase of menstrual cycle and affects the social and individual behaviour of women. Different methods (medical and psychological) are used in the management of this disorder. The aim of this study was to determine the efficacy of Cognitive- Behavioral Stress Management (CBSM) on the depression and irritability of women with PMS. This semi-experimental study was conducted as a post-test and pre-test whit control groups. Statistical population included women of Rafsanjan city who referred to Nik-Nafs clinic in May 2009. from the women who referred to this clinic, 50 women were selected as available sample and then 24 of them, who acquired the highest score from the questionnaire estimating PMS, were selected as final sample and randomly assigned into two equal groups. Data were gathered by GHQ-28 and questionnaires for estimating PMS Symptoms. The women in the interventional group took part in a 90-minutes training program for 8 weekly sessions. Then, the post–test scores of the two groups were gathered. Data were analyzed by co-variance test and independent t-test using SPSS software. The mean scores of depression and irritability were 24.7 ± 5/6 and 26/6 ± 7.9 respectively. After intervention the scores for depression and irritability were 19/9 ± 7.4 and 20/77 ± 7.3 respectively. These values statistically significant (p= 0.01, p= 0.03). The results of this study showed that CBSM can improve PMS symptoms.

Supplementary feed exogenous enzymes have improved the growth rates of various food animals. In this research, the effect of Endofeed W, a multienzyme feed supplement, was investigated on the growth of carp. Accordingly, 134 fish (33.1 ± 0.8 g) were randomly allocated to 4 experimental groups. During the first stage of the experiment (10 days), groups 1-3 received 1, 2 and 3 g Endofeed W per kg diet, respectively. The fourth group (control) received a placebo. All fish were weighed and redistributed for the second stage of the experiment, during which the test groups received 0.25, 0.5 and 1 g Endofeed W per kg diet, respectively. During the first stage of the experiment, the multienzyme supplement reduced the fish weights, dose dependently, being statistically significant with the highest dose (P<0.05). During the second stage of the experiment, a rather similar weight loss, especially with higher doses of the supplement, was observed. However, the differences were not significant (P>0.05). The feed conversion rates were evidently higher in groups receiving Endofeed W. The present study suggests the enzyme supplement, Endofeed W, is not only ineffective in improving the growth and feed conversion rates of carp, it may even exert negative effects with higher doses.

Introduction & Heart failure that is a major health problem with increasing incidence with the aging of the population often occurs as a result of ischemia and coronary artery disease. Allopurinol can protect the ischemic heart muscle and improve the use of energy during myocardial ischemia. The aim of the present study was to evaluate the effects of allopurinol on the left ventricular function in patients with heart failure. In this clinical trial study eighty-two patients randomized to receive either allopurinol or placebo, in addition to the standard treatment. Echocardiography evaluation was performed.before the treatment and 6 months after the treatment At the end of the study, the rate of change in LVEF compared to the baseline was also significantly greater in the allopurinol-treated patients than the control. Improved New York Also Heart Association class(NYHA class) occurred more in the patients receiving allopurinol compared to the controls. In the patients with heart failure, long-term administration of allopurinol in addition to improving left ventricular function, has beneficial effects on their quality of life.

Staphylococcus aureus is one of the most prevalent causes of gastroenteritis worldwide. Knowing the precise boundary for the growth/no growth interface of S. aureus and also determining the period of time needed for bacterial growth initiation is necessary for food safety risk assessment. This study was designed to examine the combined effects of temperature, acetic acid, inoculum level and NaCl concentration on the growth of S. aureus in brain heart infusion broth. Growth was monitored by visible turbidity over a 20 days period. Statistical analysis of data showed significant effects for selected parameters on growth of S. aureus. Stepwise multiple regression was used to predict the growth initiation (R2 = 0.91, P<0.0001). To obtain a boundary model, logistic regression was used. The models accurately predicted the growth initiation and inhibition of S. aureus.

Blood-borne infections are important threatening problems for health care staff which needs more attention. Heart surgery and invasive heart procedures are major risks for transmission of viruses like HBV, HCV, and HIV to patients and medical staff. Therefore this study was performed to assess prevalence of such infections in these patients. This descriptive survey included all the patients who had been admitted for cardiac surgery or invasive cardiac procedures in Emam Ali Hospital in Kermanshah from 1999 to 2003. Data collected from medical records, were analyzed by means of T and X2 tests. P. value <0.005 regarded significant. Among 6820 cases, 112 patients had positive HBV and HCV tests (1.6 percent) with 89 HBV positive (1.3 percent) and 31 HCV positive (0.45 percent) cases. (8 patents were both HCV and HBV positive) 76 patients were male (74%), and the remainder were female.No HIV positive patient was detected. Positive cases were more common in hospitalized patients, those with history of previous surgery and blood transfusion, addicts and housekeepers. Data analysis by means of X2 test showed significant correlation between presence of HCV and HBV infection with history of transfusion (p. value=0.001) and previous surgery (P. value=0.015) but not with addiction (p. value=0.675). The variables of education level and job were not found to be risk factors. prevalence of hepatitis among cardiac Patients is similar to general population, so performing routine HBV, HCV, HIV tests in high risk groups should be regarded more important.

Manna taranjebin is produced by an insect, Poophilus nebulosus, on camel's thorn plant. The manna has been traditionally used in herbal medicine and recent studies have studied/confirmed some of its therapeutic effects. In this study, some potential toxic effects of taranjebin were studied. In the first experiment, 4 groups of 6 mice (25.60.40g) received different doses of taranjebin (0.6-4.8g/kg/d) orally. The control group (n=6) received similar volumes (10ml/kg) of normal saline. In the second experiment, different groups of mice (n=5, 25.6±0.45g) were injected similar doses of taranjebin or placebo intraperitoneally. In both studies, the mice were watched for clinical sings during 10 days of experiments. Weight gains were measured in both experiments, and the mice in the second experiment were blood sampled for assessment of serum urea, creatinine, total bilirubin, alkaline phosphatase (ALP) and alanine aminotransferase (ALT). No significant differences, regarding weight gain or the studied serum parameters, were observed between the control groups and those receiving taranjebin. It is concluded that even in high doses, taranjebin does not exert detectable toxic effects in the studied variables.

To determine the most suitable sowing date for rapeseed cultivars this study was carried out in Busheshr Agriculture Research Center, Borazjan in 1997-1998 cropping season using a strip plot design with four replications. Rapeseed cultivars were: Global, Regent, Tower, Pf7045/91, Pf5045/88 and Maluka which were sown on four different dates with fifteen days interval (oct.20, nov.5, No. 20 and dec.5). Each plot was four row (3m), with 50cm row distances. Results showed that mean seed yield was highest (1509 kg/ha) when sown on oct.20. Interaction between sowing date and cultivars indicated that Pf7045/91 and Pf5045/88 sown on oct. 20, produced the highest mean seed yield of 2010 and 1840 kg/ha, respectively. Results of correlation studies indicated that grain yield had a positive and significant relation with oil yield, plant height and height of first pod. The heighst correlation was determined between seed yield and oil yield(r=0.99) and there was no significant correlation between the other traits.

Chlorhexidine is bonded well to the oral mucosa and dental pellicle and is poorly absorbed from the astrointestinal tract, but in high concentration it is absorbed enough to produce liver necrosis. In this case a dentistry student accidentally ingested a shot of 20% chlorhexidine gluconate solution. Treatments included washing the oral cavity with lots of tooth paste, drinking of 5% alginate syrup and ingestion of 5g small pieces of cork. The following adverse effects were experienced: headache, giddiness, mild mist, euphoria, stomachache, diarrhea and complete loss of taste sensation for 8h, which recurred gradually during the last 48 hours. According to the poor absorption, low toxicity and low concentration of conventional mouthwashes, systemic toxicity following drinking of some shots of this solution is rare. Ultimately if may cause gastritis. Other treatments which are helpful in the same cases are: drinking of hard water, kaolin and tragacant syrup, bicarbonates such as baking soda, carbonates such as beverage, citrates such as lemon-juice and chlorides such as brine and so on.