khairollah asadollahi

Gastric Cancer ranks as the fourth most common cancer globally, with the second highest mortality rate. Given its significance, this study aims to ascertain and explore the 1-5-year survival rates of patients diagnosed with Gastric Cancer.

This descriptive analytical study examines data from patients diagnosed with Gastric Cancer in Sagheze city, Kurdistan province, spanning from 2010 to 2018. Data from 236 patients with confirmed Gastric Cancer diagnoses, including demographic information, date of diagnosis, tumor morphology, tumor site, and tumor stage, were collected from the Cancer Registry Center at Kurdistan University of Medical Sciences and the Digestion and Liver Research Center at Tohid Hospital in Sanandaj. The data were then analyzed using SPSS 22 software, employing survival analysis based on the Kaplan-Meier method, the Log-rank test statistic, and Cox regression.

Of the patients, 159 (67.4%) were male, with a mean age at diagnosis of 68.46±15.50 years. Tumor morphology varied, with 132 (55.9%) categorized as unspecified neoplasms, 39 (16.5%) as invasive types, 35 (14.8%) as adenocarcinomas, 22 (9.3%) as intestinal types, and 8 (3.4%) as diffuse types. Gender (p=0.190), tumor site (p=0.084), and tumor stage (p=0.739) showed no significant relationship with the 1-5-year survival rate. However, age at diagnosis (p>0.001) and tumor morphology (p>0.001) were found to influence survival rates, which were estimated at 43%, 40%, 39%, 39%, and 36% for years 1 to 5, respectively.

 Age at diagnosis, tumor site, tumor morphology, tumor differentiation, and treatment type emerge as crucial factors influencing disease prognosis and patient survival.

Abortion, a common pregnancy complication, is influenced by multifaceted reproductive, economic, social, and cultural factors. This study investigates abortion determinants among pregnant women in Khorramabad, Iran, from September 2020 to March 2021.

This case-control study involved 416 pregnant women (208 cases, 208 controls) selected from Khorramabad health centers through census and random sampling during the COVID-19 pandemic. Data on demographics and pregnancy history were collected using a checklist and analyzed with STATA16.

Among the 416 pregnant women, the mean age was 31.00 ± 5.53 years in the control group and 32.27 ± 6.85 years in the case group. Furthermore, 74 (35.58%) mothers in the case group had a diploma, 192 (92.31%) were housewives, and 106 (50.96%) had A+ blood group. The majority of mothers (46.63% in case, 39.42% in control) had an overweight range of pre-pregnancy BMI (25-29.9) (kg/m2). The mean height was 162.97 ± 5.30 in the control group and 160.86 ± 5.39 in the case group. Multiple regression logistic analysis confirmed significant associations between abortion and mother's age (OR=4.67, 95%CI=1.11-19.62), previous cesarean delivery (OR=4.33, 95%CI=1.94-9.66), not taking folic acid pills during pregnancy (OR=14.92, 95%CI=6.25-35.61), low income (OR=7.00, 95%CI=2.02-24.35), not smoking (OR=0.28, 95%CI=0.08-0.94), and absence of pre-diabetes (OR=0.13, 95%CI=0.03-0.47) (p < 0.05). No significant relationships were found between abortion and other studied risk factors.

 Older mothers with lower income levels are more likely to experience abortion. Additionally, factors such as pre-existing pre-diabetes, previous cesarean deliveries, smoking, lack of folic acid supplementation, and maternal infections are identified as risk factors for abortion. Providing education, healthcare, and continuous support from healthcare workers can promote safe pregnancies, reduce the risk of abortion, and enhance maternal and child health outcomes.

The Apgar score, assessing newborns' health at birth, indicates adverse conditions and the need for medical attention. This study investigates its predictive value for neonatal outcomes.

This retrospective cohort study involved 207 neonates in Ilam city hospitals (2015-2016). It compared two groups: 69 neonates with Apgar scores <7 (exposed) and 138 with scores ≥7 (unexposed) at birth. Neonates were followed through the neonatal period, and outcomes were compared. Statistical analysis used SPSS Statistics software.

At the fifth minute, the exposed group had higher rates of resuscitation need (51% vs. 26.7%, p=0.01), re-admission (51% vs. 31.1%), and mortality (60% vs. 12.2%, p=0.03) compared to the unexposed group. Relative risks for the exposed group were 3.8 (resuscitation), 6.1 (NICU admission), 2.94 (re-admission), and 2.5 (mortality) at the first minute, and 2.9, 2.7, 2.3, and 19.9, respectively, at the fifth minute.

 Apgar scores <7 increase the risk of adverse neonatal outcomes including NICU admission, resuscitation, and higher mortality rates. The Apgar score serves as a valuable predictor of adverse neonatal outcomes.

Strokes rank among the leading causes of death and disability worldwide, with acute ischemic stroke (AIS) on the rise in Iran. Thrombolytic drugs constitute a primary treatment for ischemic stroke. However, due to limited studies in Iran, there exists hesitation among physicians regarding their administration. This study aims to assess the efficacy of these drugs on AIS patients.

In a clinical trial, 80 patients with ischemic stroke were divided into treatment and control groups. Both groups were assessed upon admission and 72 hours later using the National Institutes of Health Stroke Scale (NIHSS) and the Modified Rankin Scale (mRS) scores at discharge. The treatment group received Alteplase (0.9mg/kg), while the control group received standard care. Statistical analysis was performed using SPSS 20.

The mean NIHSS ± SD scores at admission and 72 hours later in the treatment group were 10.0±3.51 and 4.55±8.75, respectively, compared to 8.53±3.52 and 7.88±9.21 in the control group, showing a significant difference in favor of the treatment group (P < 0.001). Similarly, the mean mRS± SD score in the treatment group was 1.68±1.79, significantly lower than the control group's 3.15±1.61 (P < 0.001).

 Intravenous Alteplase administration proved effective in treating patients with ischemic stroke, significantly reducing neurological complications and disabilities compared to standard medical care.

Behavioral and personality traits of family members, especially the parents can affect a child's behavior. According to high prevalence of mental disorders in Iran, this study was conducted to determine the relationship between personality disorders in parents and psychiatric disorders in children and adolescents.

A cross-sectional-analytical survey was performed in children and adolescents aged 6-18 years in Ilam and its suburbs, west of Iran, 2018-2019. A total of 1022 children and adolescents were selected using multi-stage cluster sampling. Semi-structured interviews were carried out and data were collected using Kiddie-SADS-Present and Lifetime Version (K-SADS-PL) and Millon Clinical Multiaxial Inventory. Data analysis was done applying descriptive statistics and calculation of odds ratio with 95% confidence interval.

The prevalence of psychiatric disorders was 10.80% in boys and 8.15% in girls. The most prevalent disorders in boys were depression (0.81%), enuresis (3.67 %), hyperactivity (1.84 %), and specific fear (1.22 %) and in girls separation anxiety (4.17%) was more common. Findings showed significant direct relationships between depressive personality disorder in mothers and depression in children (OR= 1.07, 95% CI: 1-1.14, P=0.02) and between depressive personality disorder in fathers and nocturnal enuresis in children (OR= 1.07, 95% CI: 1.01-1.14, P=0.02), and also between avoidant personality disorder in fathers and specific fear disorder in children (OR=1.09, 95% CI: 1-1.20, P=0.04).

In this study, we observed high prevalence of psychiatric disorders in children and adolescents that are significantly linked to the personality traits of parents and should be taken into account in making diagnosis and designing interventions.

Short children face many problems throughout their lives. Consumption of growth hormone and the drugs such as Letrozole, Oxandrolone, and Anastrozole can increase the growth of children and adolescents. There is not an overall estimate of the effects of Letrozole, Oxandrolone, and Anastrozole on the growth of children and adolescents with Idiopathic Short Stature (ISS). There are different estimates of the effect of growth hormone and the drugs Letrozole, Oxandrolone, and Anastrozole on growth in children and adolescents with Idiopathic Short Stature. Therefore, the aim of this study was to compare the efficacy of growth hormone, Letrozole, Oxandrolone, Anastrozole, and a combination of growth hormone and aromatase inhibitors on height gain in children and adolescents with idiopathic short stature using meta-analysis method.

Search was done in databases such as; Scopus, Web of Science(ISI), and PubMed using keywords: Idiopathic, Short Stature, Body Height, Aromatase Inhibitors, Growth hormone, Letrozole, Oxandrolone, Anastrozole. Randomized clinical trial studies ,that have investigated the efficacy of growth hormone and aromatase inhibitors on height gain in children and adolescents with short stature, were selected. Height standard deviation score (HSDS) before intervention and after treatment has been used to measure the rate of height increase in various studies. This study was written based on the PRISMA checklist and the heterogeneity of this study was evaluated using the Q statistic and I2 index.

Height increase index (HSDS) was obtained with the use of growth hormone combined with one of the aromatase inhibitors (0.38-3.58=95%CI) (SMD=0.98), with the use of growth hormone (0.62-1.14=95%CI) (SMD=0.88), with the use of Letrozole (0.51-16.51=95%CI) (SMD=0.83), with the use of Oxandrolone (0.99-0.99=95%CI) (SMD=0.56), and with the use of Anastrozole (0.00-0.63=95%CI) (SMD=0.31), which shows that all these drugs have a significant effect on height increase. (P<0.05)

Although the effect of growth hormone on height increase was greater than that of aromatase inhibitors, but according to our results, adding an aromatase inhibitor to growth hormone can increase the effectiveness of it.

Pulse pressure has recently been considered as a predictor of coronary heart disease. The difference between systolic and diastolic blood pressure is called pulse pressure. Various factors including increased age, vascular stiffness, stenosis, and hypertension are associated with pulse pressure. The present study, therefore, aimed to investigate the relationship between some cardiovascular function indicators such as vascular stenosis, blood pressure and cardiac output with pulse pressure as a predictor of cardiovascular diseases.

This case-control study was performed on 544 patients who were referred to Imam Ali Hospital in Kermanshah, Iran, from March 2015 to February 2016. In this study, according to the angiographic findings, individuals with artery stenosis were considered as the case group (n=272) and those without artery stenosis were considered as the control group (n=272). Statistical analysis was performed using descriptive statistics, Chi-square and odds ratio estimation by SPSS22 software.

According to the findings of this study, ages over 50 (OR: 3.3, 95% CI: 2.1-5.2), high systolic blood pressure (OR: 8, 95% CI: 4.3-15.2), high diastolic blood pressure (OR: 4.9, 95% CI: 2.0-11.7), cardiac output less than 50% (OR: 1.8%, 95% CI: 1.3-2.7) and vascular stenosis (OR: 3.5, 95% CI: 2.4-5.1) were associated with high pulse pressure. The male gender had a preventive role in increasing of pulse pressure (OR: 0.7, 95% CI: 0.5-0.9). A significant relationship was demonstrated between systolic blood pressure and pulse pressure (P<0.0001).

Based on the findings of the present study, the chances of having high pulse pressure are high among individuals over 50 years of age, female gender, those with elevated systolic and diastolic blood pressure, and individuals with high coronary artery stenosis. This chance is associated with decreased cardiac output and coronary stenosis. Increased pulse pressure is a predictive indicator of cardiovascular disease and it is recommended that pulse pressure measurements of all referrals, especially those who are being referred to cardiology clinics, are taken into account by medical professionals to prevent adverse clinical outcomes.

Apgar score is a method for clinical evaluation of neonate at birth, and predicts their clinical conditions and physical or mental development. This study aimed to investigate the relationship between some neonatal and maternal factors during pregnancy on the Apgar score.

This case-control study was conducted on 234 neonates born in Ilam hospitals during 2015-2016. The case group included 81 neonates with Apgar score

The mean maternal weights in the case and control groups were 66.8 ± 13.5 and 67.1 ± 11.1 Kg, respectively. The mean± SD for maternal age 29 ± 5 vs. 29 ± 5.7 years, marriage age 22 ± 3 vs. 22.2 ± 4.9 years, BMI 24.5±3.2 vs. 26.1 ± 4.1 and weight gain during pregnancy 13.8 ± 6.2 vs. 12.7 ± 6.8 kg among cases and controls, respectively. The odds ratio for the following factors was significantly higher among cases than the control group: preterm delivery (OR: 3.3, 95% CI: 1.2-17), twin birth (OR: 8.9, 95% CI: 2.6-27.2), abnormal presentation of the fetus (OR: 6, 95% CI: 2.3-15.6), birth weight (OR: 6.9, 95% CI: 1.4-28.6), and placental abruption (OR: 9.4, 95% CI: 2.2-22.5) for Apgar score at five minute.  

Based on the findings of the present study, preterm labor, multiple birth, and abnormal fetal presentation, and low birth weight, premature rupture of membrane, placental abruption and anemia, led to an increase in Apgar score less than 7.

Suicide is a preventable social harm in the field of health. The present study aimed to design a prediction model for suicide incidence based on Box-Jenkins model in Ilam province.

Using a retrospective method all completed and attempted suicide data were collected during 1993-2013. Then, using the autoregressive integrated moving average (ARIMA) model, the time series analysis of the Box-Jenkins model was conducted to predict suicide status in the coming years (2014-2015).

According to the actual results obtained from the suicide data in 2014, a total of 1078 suicides were recorded and compared to the predicted results, according to the fitted model of the time series, which showed the selected model predicted 931 suicide cases, showing 86% accuracy of prediction. The series’ prediction indicated 931 suicides in 2014 with a negative growth rate of 25.3% compared to 2013 and 969 suicide cases in 2015 with a positive growth rate of 3.93% compared to 2014.

The results of this study showed the designed model provides a high diagnostic value to predict suicide rates. These types of models can help to predict suicide in future and plan to control and prevent suicide attempts.

Osteoporosis is one of the most common bone diseases that is caused by an imbalance between the activity of osteoblasts and osteoclasts. Osteoprotegerin (OPG) plays an active role in inhibiting osteoclasts by binding to the receptor activator of nuclear factor kappa-B ligand (RANKL). The balance in the OPG/RANKL ratio is important in bone remodeling. The current study investigated and compared the effects of mumie extract and chemical drugs on cell proliferation, expression of OPG and RANKL in MG63 cells.

The effects of 100, 200 and 300 μg/ml of mumie extract on cell proliferation, expression of OPG and RANKL in MG63 cells were investigated in experimental groups, positive and negative control groups. Data were analyzed by ANOVA test.

Significant increases were observed in the proliferation of MG63 cells after exposure to 100 and 200 μg/ml concentrations of mumie extract. 200 μg/ml concentration of the extract significantly decreased the expression of RANKL and increased the expression of OPG. It also increased OPG/RANKL ratio significantly in the experimental groups, compared to those in the negative control groups. Although the effects of 100 μg/ml and 200 μg/ml concentrations were similar to each other, they showed no significant effects on the variables. 300 μg/ml concentration of the extract showed a reverse and insignificant effect.

200 μg/ml concentration of mumie extract had a significant effect on the expression of two important factors in bone remodeling. Therefore, individuals susceptible to osteoporosis can use mumie extract as an alternative to chemical drugs.

Among Middle East countries, the prevalence of Metabolic Syndrome (MetS) and Type 2 Diabetes Mellitus (T2DM) dramatically increased in Iran. Very few evidence-based studies have been performed on the relationship between metabolic disorders and colorectal cancer (CRC) in developing countries at least in Iran.

This case-control study aimed to determine the relationship between MetS and CRC risk.

A case-control study with 414 participants (207 cases and 207 controls) was conducted among referral hospitals (Imam Reza, Shahid Madani, and Sina) in Tabriz, Azerbaijan province, Iran. Cases with CRC confirmed by positive pathology and colonoscopy findings were selected and compared with the controls without neoplastic and chronic diseases at the same time and hospitals for the cases. Group matching was used based on sex and age variables for the case and control groups. MetS was defined by the International Diabetes Federation (IDF) criteria. Multiple logistic regression was used to estimate adjusted odds ratios for the association between MetS and odds of CRC.

Out of 414 participants, 220 (53%) were men. Among the cases, 134 (64.73%) patients had MetS, while in the control group, 82 individuals (39.61) had MetS history. After adjusting for the confounders, MetS and DM history were significantly associated with elevated odds of CRC (OR: 2.79, %95 CI: 1.58 - 5.15, P = 0.001) and (OR: 2.57, %95 CI: 1.25 - 4.58, P = 0.006), respectively. We have observed also a dose-response relation and a trend between the components of MetS and CRC risk. So, the odds of CRC increased by rising numbers of MetS components.

It seems that MetS and its components are associated with an increased risk of CRC

This study compares the effects of two drug regimens for Helicobacter pylori (H. pylori) infection resistant to the first line drug regimen among patients referred to Ilam clinics, Iran. Single drug regimen is not effective for H. pylori infection and therefore, application of triple or quadruple drug regimens are currently applied. This study was performed by a before-after comparative method and patients were randomly selected among those consecutively referred to Ilam gastrointestinal clinics. Patients with failure in the first line treatment, were randomly divided into two equal groups and each group was treated by one of the PPI+Amoxicillin+Rifampicin or PPI+Amoxicillin+Levofloxacin drug regimens for 14 days. Six weeks after treatment, patients were tested for H. pylori stool antigen and the results were compared between two groups. In this study, 100 patients including 49 (49%) men and 51 (51%) women were examined. There was no statistical difference between the two groups for gender, age and living location at the start of study (p = 0.068). The mean age of the patients was 44.55 ±15.1 years old ranging from 17 to 85 years. Response to treatment among the levofloxacin group, was 90% and in rifampicin group 72% with a significant difference (p<0.04). The response rate of H. pylori infection to the Levofloxacin based regimen was 90%; however, the application of rifampicin in combination with other drugs against H. pylori infection (72% response rate), should be limited to reduce the possibility of drug resistance in case of tuberculosis infection.Keywords: Helicobacter pylori, Levofloxacin, Rifampicin, PPI, Drug resistance.(Please cite as: Abangah GH, Raughani A, Asadollahi P, Asadollahi KH. Comparison between the two drug regimens of PPI+Amoxicillin+Rifampicin and PPI+Amoxicillin+ Levofloxacin for the treatment of H. pylori infections resistant to the first line drug regimen among patients referred to Ilam clinics Gastroenterol Hepatol Bed Bench 2019;12(3):209-216).

Congenital hypothyroidism is an endocrine disorder and is one of the main causes of mental retardation in the newborns. Genetic, environmental and geographical factors are associated with the disease. This study aimed to evaluate the incidence rate and correlation of geographical factors with congenital hypothyroidism in Ilam Province. This study was a descriptive analytical study and evaluated the incidence rate and geographical distribution of congenital hypothyroidism in the newborns in Ilam Province from the beginning of 2006 to the end of 2016. We studied the results of heel samples of the newborns between 3 to 5 days of age who had been screened for congenital hypothyroidism in the referral laboratories of the health centers of the health department of the Ilam University of Medical Sciences in all cities of Ilam Province. We used ArcGIS (ver 10.3) software for evaluation of geographical distribution. Statistical tests of Poisson regression and scatter plot were used to investigate the relationship between geographical factors and the incidence rate of congenital hypothyroidism. Data analysis was performed by use of SPSS 16 software. Based on the findings of the screening of 106900 newborns born in Ilam Province, the incidence of congenital hypothyroidism in this study was 2.61 in 1000 live births (2.7 male newborns / 1000 live births, and 2.48 female newborns / 1000 live births). Among all the patients 55.4% were male and 44.6% were female. There was a significant correlation between the mean annual rainfall and herbal coverage with congenital hypothyroidism (p0.05). Based on the findings of this study, incidence of congenital hypothyroidism is high in Ilam Province. Abdanan and Ilam cities had the highest incidence rates of hypothyroidism and are among the high risk hotspots of the disease. As a result, authorities should take appropriate measures in order to control and reduce the incidence of this disease in the province. Also, among the geographical factors, the mean annual rainfall, herbal coverage and sunlight were associated with congenital hypothyroidism.

Congenital anomaly is a disturbance in fetal growth and development during pregnancy and is one of the main causes of morbidity and mortality in the first year of life. In addition, this anomaly causes a large waste of heath care resources. We aimed to determine the prevalence and proportion rates of different congenital anomalies in Iran via a systematic review and meta-analysis.
The present study was performed to estimate the prevalence and proportion rates of different anomalies in Iran via a systematic review and meta-analysis. Therefore, all the studies performed in Iran between 2000 and 2016 were evaluated. For this purpose, Medlib, Scopus, Web of Science, PubMed, Cochrane Library, Science Direct, Google Scholar, Irandoc, Magiran, IranMedex, and SID databases were searched by two different expert individuals independently. For the qualification survey of the papers, the Strengthening the Reporting of Observational Studies in Epidemiology checklist was applied. Then, the extracted data were entered into STATA (ver.11.1) and analysed using statistical tests of stability and random effects models in meta-regression, a tool used in meta-analysis. The 95% confidence intervals were calculated by I-square models. Meta regression was introduced to explore the heterogeneities among studies.
Overall, 36 papers with a total sample size of 909,961 neonates were analysed. The total prevalence rate for congenital anomalies was 18/1000 live births, 23.2/1000 and 18/1000 for boys and girls, respectively. Moreover, 55.8% of all congenital anomalies pertained to boys. The greatest prevalence and proportion rates of congenital anomalies belonged to musculoskeletal disorders followed by urogenital anomalies (9.3/1000 [34%] and 5.7/1000 [20%], respectively), and the lowest figures belonged to chromosomal and respiratory system anomalies (0.8/1000 [6%] and 0.3/1000 [2%], respectively).
According to the findings of this meta-analysis, the prevalence of congenital anomalies is notably high in Iran and annually imposes huge visible and non-visible expenses on individuals, societies, and heath care systems. Therefore, preparation of tools and centres for the early diagnosis and prevention of birth defects and rehabilitation of those with congenital anomalies throughout Iran are essential.

Spinal cord injury (SCI) is a serious clinical disorder, which involves the patient’s family as well as the community. After sever SCI, astrocytes of the central nervous system become reactive astrocytes, and produce glial scar which is a major obstacle to axons regeneration in the spinal cord. However, some studies have confirmed a spontaneous partial locomotor recovery in injured animals in the course of time and without any therapeutic interventions. Thus, in this study, locomotor function of animals with SCI was assessed to determine the exact scope of such a recovery through BBB (Basso, Bresnahan and Beattie) locomotor test during 20 weeks.
In this research, 18 adult male Wistar rats were used and randomly divided into 3equale groups: the normal control, the sham, the injured. Animals in the normal control group did not received any intervention, but for the sham and injured groups, laminectomy and contusion model in segment T10 of spinal cord were accomplished, respectively. Locomotor improvement of animals in all the groups was evaluated for 20 weeks.
Findings: According to our investigation, comparison of the results of locomotor assessment of the second week against that of the 20th week of the spinal cord injured group without treatment demonstrated a partial locomotor recovery, since the BBB score of lesion in these animals was 1.4 in the second week and reached up to 16 in the Twentieth week.
Discussion & Our Results showed that spontaneous locomotor recovery in animals with spinal cord defects increases after 20 weeks (from 16 21 score) in the course of time and without any therapeutic interventions

Spinal cord injury (SCI) causes constant irreversible functional deficits. Poor prognosis of such a disease prompts scientists to work on an effective way of treatment. Stem cell transplantation provides a promising strategy for such researchers. Using olfactory ensheathed cells (OECs) has, so far, indicated very good results. Hensce, the purpose of this study was to evaluate the effectiveness of transplanted OECs on functional recovery of delayed phase of SCI in rats.
In this survey, eighteen adult male wistar rats were divided into sham, control, vehicle, and treatment groups. Sham group received only laminectomy in the T9 segment of spinal cord, while in other groups, contusion model was induced following laminectomy.7 days after injury, DMEM medium alone or with OECs was injected to the vehicle and treatment groups, respectively. For cell culture, the olfactory mucosa of 7-day-old male wistar rats was used. Locomotor behavior of animals in all the groups was evaluated by BBB, (Basso, Bresnahan and Beattie) test.
Findings: Comparison of the results by the second week to the end of the study illustrated significant changing differences between the OECs receivers and the control group, (pDiscussion & Our investigation demonstrated a positive impact of the OECs on functional recovery in the delayed phase of SCI.

Premature neonates are hospitalized until they can get full mouth feeding and this often leads to increasing the hospitalization period. This study compared two neonatal care policies: early discharge of stable preterm infants with home gavage feeding and discharge when they reached to full oral feeding.
By a case-control study, all stable premature neonates admitted in Alzahra teaching hospital, Tabriz, Iran, who were not able to feed orally, were divided into two groups. Study group included 48 neonates who achieved full oral feeding through oro- gastric tube and were discharged for outpatient follow-up. Control group included 50 neonates with the same feeding conditions who remained hospitalized and fed up by their mothers. Within one month, early clinical criteria were compared between both groups.
The mean gestational age for the control group was (30.6 ± 2.5 weeks), study group was (30.2 ± 1.8 weeks) and average admission weights for control and study groups were 1409.0 ± 363.6gr and 1352.7 ± 272.3gr, respectively. Infants at the early discharge program, spent less time to reach the full oral feeding (13 days vs. 16 days) than the control group (p = 0.025), and had lower risk of sepsis and feeding intolerance compared to those in the control group and their difference for feeding intolerance was significant (p= 0.03).
This study showed that after an appropriate education for parents the early discharge of stable preterm neonates with home gavage feeding not only revealed a positive impact on their feeding and sucking improvement but also did not show any complication or negative impact on their growth parameters.

Intrauterine growth retardation (IUGR) is a physiological and pathological process resulting in a slow fetal growth, and not only increases fetal mortality, but also is associated with adverse outcomes during infantile and adulthood. Therefore, this study was performed with aim to determine the prevalence and risk factors associated with IUGR in Ilam province.
In this descriptive-analytical study, at first, the prevalence of IUGR was measured by cross-sectional method among all newborns during 2014 in Ilam province. Then, by designing a case-control study, 781 newborns (247 cases and 534 controls) were enrolled. All the newborns with birth weight below than 10th percentile were selected as case group and the newborns with birth weight above the 10th percentile were considered as control group. They were selected via simple randomization method. The required information including demographic and clinical data was obtained from hospital records. Data was analyzed by SPSS software (version 16) and Chi-square and Fisher exact tests and logistic regression model. P The prevalence of IUGR among 9503 neonates in Ilam province during the study period was 2.8%. There was a significant relationship between IUGR and multiple pregnancy (P=0.0001), history of IUGR (P=0.02), mother's residency place (P=0.001), autoimmune diseases (P=0.03), kidney diseases (P=0.01), preeclampsia (P=0.0001), hyperemesis gravidarum (P=0.01), treated hypothyroidism (P=0.009) and mode of delivery (P=0.001).
The prevalence of neonates born with IUGR in Ilam province was in accordance with global standards. Multiple pregnancy, history of IUGR, preeclampsia, hyperemesis gravidarum, autoimmune and kidney diseases and rural residency increase the chance of IUGR.

The deficiency of enzyme glucose-6-phosphate dehydrogenase (G6PD) is among the most common genetic diseases in human. The deficiency of G6PD enzyme is one of the most common encountered enzymes, affecting about 400 million people and causing a wide range of undesirable clinical complications worldwide. The performed studies have reported a variety of statements about the relationship between malaria and survival of people with defect, but these kinds of studies are limited in Iran. This study aimed to estimate the incidence of G6PD deficiency among newborns in malarious areas of Fars province.
The present study was conducted ecologically and descriptively-analytically on 59745 neonates with G6PD deficiency in Fars province, Iran from April 2011 to March 2015. To determine the defect, a point fluorescence test and Kimia commercial kit (KimiaPajoohan Co., Tehran, Iran) were used. To determine the areas with malaria, factors associated with malaria-causing cells in Fars province, including the presence of carriers, the presence of malaria, the incidence of new malaria and the presence of malaria activated sites were studied. The incidence of defect was calculated using the statistical method of estimating the annual incidence rate. ArcGIS software, version 10.3 (ESRI, Redlands, CA, USA) was used to provide geographic mappings and distribution patterns in malarious areas.
The total incidence of G6PD deficiency in newborns was estimated as 15.58 per 100 live births, including 16.25 for boys and 14.85 for girls. The incidence of this defect in malaria-prone areas was higher than other areas. As a region was more malaria-prone, the incidence of G6PD deficiency increased too, which was statistically significant (P= 0.039).
Based on the findings of this study, Fars province is among areas with high incidence of G6PD deficiency. The incidence of G6PD deficiency in malaria-prone areas of Fars province, Iran, is higher than other regions, which indicates better survival of patients against malaria in the past.

Glucose-6-phosphate dehydrogenase deficiency (G6PD) or fauvism is the most common enzyme deficiency in human, so that 400 million people are living with this disease worldwide. This study aimed to investigate the role of some neonatal factors among newborns suffering from G6PD deficiency and neonatal outcomes associated with this disease.

In this study, two methods including case-control and retrospective cohort regarding some neonatal factors associated with G6PD deficiency were used. These methods were performed on 142 children with this kind of deficiency and 142 healthy infants in the city of Marvdasht during 2013- 2014. The analysis of data was based on chi-square tests, t-test, logistic regression, descriptive statistics and estimation of odds ratios or relative risks via SPSS16 software.

Totally 284 newborns including 132 (46.6%)/ 152 (53.4%) boys/girls and mean weight on birth of 3163 ± 471 (gr) were analyzed. Comparison of case and control samples did not show any significant differences between sex and involving with G6PD deficiency but the chance of having a baby with this defect in pregnancy intervals between 6 to 8 years was increased (95% CI: 1- 4.4, OR: 2). Relative risk of jaundice in infected and healthy infants was estimated as 3.73, which demonstrated a statistically significant association (95% CI: 1.33- 10.4). The frequency of low birth weight, birth order and type of delivery was associated with the disease, but their differences were insignificant compared to the healthy group.

The results of this study showed that the number of hospitalization is increased due to jaundice in infants with G6PD. There is also an insignificant relation between low birth weight, rank of birth and type of delivery. Thus, it is recommended that other consequences of this deficiency need to be revealed by screening other populations with more samples.

Suicide is one of the main health problems in different societies and is associated with different risk factors. The result of a suicide attempt is directly related to the selected method. Invasive suicides are known as violent methods of self-harm and are usually happened in different patterns of age and gender. The aim of this study was to investigate the outcome and varieties of suicide via invasive methods in a long-term period in Ilam province, Iran.
In this retrospective study, the required data, including demographic variables, outcomes and the kind of invasive method was extracted from a comprehensive registration system of suicide cases, recorded by Ilam University of Medical Sciences (IUMS), to investigate the invasive suicides during the 1993-2013 years. The study was approved by the Ethics Committee of Ilam University of Medical Sciences and based on this approval the permission to access the suicide data was issued. Data were entered into the SPSS 20 software (SPSS Inc., Chicago, IL, USA) and using descriptive statistical methods and chi-square were analyzed based on completed or attempted outcome of suicide.
Among a total of 1516 cases of invasive suicide, 643 (42.6%) were attempted and 867 (57.4%) were completed suicides. Self-immolation method showed the highest frequency of suicide (both completed and attempted). The highest frequency of completed suicide was occurred in females (52.8%) but the attempted suicide was higher in males (63.6%). The age groups of 25-34 years and above 65 years indicated the highest frequencies of attempted and completed suicides respectively.
One of the main objectives of this study was identification of high risk groups who used the invasive methods for suicide commitments, based on their epidemiological characteristics such as gender and age. The results showed that women and elderly individuals were among the high-risk groups who committed completed suicide using the invasive methods and self-immolation attributed the most frequent method among invasive methods for suicide in Ilam province which resulted in death.

To date there is no effective drug treatment for transient tachypnea of the newborn (TTN) and respiratory support is the only means to handle this disease. This study was performed to evaluate the effect of albuterol (Salbutamol) in improvement of respiratory distress in involved neonates.
We conducted a randomized, blinded, placebo-controlled clinical trial Neonates with TTN received either nebulized albuterol (30 neonates) or placebo (30 neonates), and early clinical parameters were measured during and after treatment.
Totally 60 neonates including 31 males and 29 females, mean gestational age of 36.9 ± 1.69 weeks, mean weight of 2703 ± 589 gr, were analyzed. Respiratory distress score was significantly decreased in treatment compared to placebo group (from 5.6 at the start to 1.7 at the end of study vs 5.6 to 3.9 respectively) and the PO2 was significantly increased in neonates receiving nebulized albuterol compared to the placebo group (from 58.5% at the start to 84.8% at the end of study vs 58.2% to 70.2% respectively). No adverse effects were observed in either group. The duration of continuous positive airway pressure (CPAP) application was significantly decreased in the treatment group compared to the placebo group (1.6 ± 0.77 vs. 3.3 ± 0.98 respectively) (P = 0.0001).
Application of nebulized albuterol caused a considerable improvement in the respiratory distress of neonates at its primary hour of using via reduction of respiratory scores, duration and concentration of oxygen requirement, and duration of CPAP without any side effects. Therefore, this drug can be applied in the treatment of Transient Tachypnea of the Newborn appropriately.

Spinal cord injury (SCI) is one of the most serious clinical diseases, which not only affects the patient's physical and mental status, but its effects will be spread to family and community. After severe spinal cord injury, astrocytes of the central nervous system (CNS) become reactive astrocytes, and play the main role of glial scar formation. The scar is a major obstacle to regeneration of axons in the spinal cord. However, the studies have found that over time, a spontaneous partial motor recovery is observed in animals with injury without intervention. Thus, in this study, the recovery of animals with spinal cord injury was assessed after 12 weeks.

In this study, 12 adult male Wistar rats weighing approximately 265±15gr were used to assess spinal cord injury and randomly divided into 3 groups: normal control (n = 3), sham (n = 3), injury (n = 6). Healthy animals in the normal control group received no laminectomy or injury, and laminectomy with or without contusion model using weight drop in segment T10 of spinal cord were carried out in injury and sham groups, respectively. Locomotor function of animals in all groups were evaluated by BBB test at the first 48 hours per day and then weekly for 12 weeks.

Comparison of the results of motor evaluation from the second week to the twelfth week of the group with injury without treatment showed a relative functional recovery as the BBB score of animals from 1.4 in the second week after the injury reached to 6.5 in the twelfth week.

The results indicate a spontaneous partial recovery in injured animals without intervention.

Spinal cord injuries (SCI) lead to permanent irreversible functional deficits. Poor prognosis of patients is the motivation of searching a treatment for the chronic injury. Planting stem cells provides us with a promising strategy. In the meanwhile, the use of olfactory ensheathing cells (OECs) has shown very good results. This study aims at evaluating the effect of transplanted OECs on functional recovery of acute SCI in rats.

In this study, eighteen adult male Wistar rats weighting approximately 210 ± 10 gr were used to study spinal cord injury. They were randomly divided into four groups: Sham (n = 3), Control (n = 6), Vehicle (n=3) and Treatment (n=6). In the Sham Group, only laminectomy was performed in the area of T9 spinal cord. In three groups of Control, vehicle and Treatment, after laminectomy, spinal cord contusion model was performed using the Weight drop technique. Immediately after the injury, 10μl Dulbecco's Modified Eagle Medium (DMEM) alone or with 106 cells were injected to vehicle and Treatment Group animals. For culturing cells, the olfactory mucosa of 7-day-old male Wistar rats was used. Motor function of animals in all groups, was evaluated in the first 48 hours daily and then weekly for eight weeks.

Comparing the results of the second to eighth week of the study showed significant differences in the group receiving the OECs with the control group (P<0.05).

The results indicate a positive influence of the olfactory ensheathing cells in functional improvement of spinal cord injury in the acute phase of injury.

Considering the high incidence and prevalence of nonalcoholic fatty liver disease (NAFLD) in the Iranian society and the limited number of studies to investigate its associated risk factors, the current study was designed to identify any relevant risk factor of this disease.
The present case-control study was performed among 150 nonalcoholic fatty liver disease patients and 150 normal liver participants who attended to gastroenterology clinics in Ilam city, Iran during 2014-2015. All demographic data, clinical trials and health behaviors associated with lifestyle such as nutritional status, smoking, physical activities were collected and compared between two groups.
Among a total of 300 participants in the current study, the male female ratio was 46.54% and the mean±standard deviation of all participants was 42.13±12.15 years. The mean values of total cholesterol, triglycerides (TG), low density lipoprotein (LDL), alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were significantly higher in cases than controls group (P The results of this study showed that waist circumference, BMI, serum level of ALT and TG concentrations can predict the occurrence of non-alcoholic fatty liver disease. BMI, ALT, and AST seem to be associated with the ultrasonography staging of liver in NAFLD. Therefore, these parameters could be used to predict the ultrasonography staging of liver in these patients.