فهرست مطالب mahdi azad

According to statistics provided by the Small Industries Investment Support Fund in 2017, Iranian businesses accounted for only 10% of the country's export volume. Furthermore, technology-oriented businesses with advanced products made up only 1.5% of Iran's non-oil exports, according to the United Nations Development Fund. This indicates that Iran has not been successful in this area, and its rank in this field is lower than that of other countries in the region. Developed countries, on the other hand, emphasize the expansion of agriculture and technological industries. Therefore, there is a significant performance gap and unfavorable state of Iran's economic drivers when comparing the country's statistics and current position with the lofty goals set. Also, since each of the researches have dealt with specific dimensions of the variables affecting the internationalization of businesses and the lack of research that has discussed the intensity of internationalization in relation to strategic agility and entrepreneurial orientation and digital technologies is felt, And since until the research, these structures have not been examined with this combination, this research is innovative in this sense. The purpose of this research is to investigate the impact of digital technologies on the intensity of internationalization of technology-oriented businesses, with the mediating role of strategic agility and the moderating role of entrepreneurial orientation.
The current research is a descriptive-correlational type of research with a practical purpose and data collection through a questionnaire. The statistical population of the research includes technology-oriented businesses in Iran since April 2023, which have a history of exporting. To be considered a technology business, the goods and services of these businesses must be in the field of high or medium to high technologies, and the goods offered must be in production or at least at the level of a laboratory sample (capable of technical review) and services must have sales documents. The population of this research includes 305 employees of these businesses who are active in the fields of international trade. A sample size of 170 people was obtained using available sampling based on Cochran's formula and with an error level of 5% at a confidence level of 95%. The researchers used a 13-item questionnaire with a 5-point Likert scale (5 = completely agree to 1 = completely disagree) derived from standard questionnaires to collect information. The relationships between variables were investigated using the SmartPLS3 software and the structural equation modeling method, which is a statistical model to investigate the relationship between latent variables and manifest variables.
The analysis of SmartPLS3 software showed that digital technologies have a direct and positive effect on the intensity of internationalization of technology-based businesses. Entrepreneurial orientation as a moderator and strategic agility as a mediating variable have a positive and significant effect as well. Therefore, businesses, especially technology-oriented ones, should consider the impact of digital technologies on the intensity of internationalization. They should digitize their processes by using digital technologies to enter and operate more successfully in international markets. Additionally, they should increase the intensity of internationalization by raising the level of strategic agility and using entrepreneurial orientation in their activities.
Technology-oriented companies operating in technology-intensive environments can expand the market for their technologies through internationalization of sales. They may do so in response to small, mature, or highly competitive domestic markets, or because they perceive greater opportunities in foreign markets. In general, the internationalization of technology-based firms is likely to increase as the world integrates, trade barriers decrease, and transportation and communications become more efficient. Therefore, the use of digital technologies can help businesses build better relationships with customers and suppliers, improve productivity, and facilitate faster internationalization. Therefore, it is better for businesses to consider their strategic agility while investing in the use of digital technologies so that they can quickly change their innovations according to the demands of customers and obtain specific information from competitors and improve their products. Design and develop faster and send to international markets.

Psoriasis has a wide range of mental health effects due to its clinical features and physical presentations. Psoriasis is associated with depression, anxiety, suicidal ideation, and negative body image. Body image includes a person's feelings about the characteristics and structure of the body. A negative body image is formed when a person experiences a negative evaluation or is ridiculed by others. High anxiety scores are always seen in patients with psoriasis. Depression is the most common mental disorder worldwide and is one of the major causes of disability. Psoriasis and depression reinforce each other. Many researchers have suggested a broader role for psychiatric and psychotherapeutic interventions to reduce the symptoms and severity of skin diseases. Therefore, this study aimed to evaluate the effectiveness of behavioral activation therapy and metacognitive therapy on body image concern, anxiety, and depression in psoriasis patients.

This research was quasi–experimental with a pretest–posttest design and a control group. The study's statistical population include all psoriasis patient referring to dermatology clinics in Razavi and Emam Reza (PBUH) hospitals in Mashhad City, Iran, in 2019. Of whom, 45 patients who obtained a higher score than the cut–off point in Body Image Concern Inventory (BICI) (Littleton et al., 2005), Hamilton Anxiety Rating Scale (HAM–A) (Hamilton, 1959), and Beck Depression Inventory–II (BDI–II) (Beck et al., 1996) were selected with available sampling method and randomly assigned to two experimental groups (15 in behavioral activation therapy, 15 in metacognitive therapy) and one control group. The inclusion criteria were as follows: providing informed consent to receive psychological treatment, having psoriasis, being between 15 and 45 years old, and obtaining a score higher than the cut–off point in the mentioned measurement scales. The exclusion criteria were the patient's lack of consent to receive psychological treatment, absence of more than two sessions, and not answering the questionnaires completely. The experimental groups underwent behavioral activation and metacognitive therapy in 8 sessions during 2 months, while the control group received no intervention. The participants completed Body Image Concern Inventory (BICI) (Littleton et al., 2005), Hamilton Anxiety Rating Scale (HAM–A) (Hamilton, 1959), and Beck Depression Inventory–II (BDI–II) (Beck et al., 1996). Descriptive statistics (frequency, percentage, mean and standard deviation) and inferential statistics (univariate analysis of covariance and Bonferroni post hoc test) were used to analyze the research data. Data were analyzed in SPSS software version 26 at a significance level of less than 0.05.

After controlling the effect of the pretest, findings showed significant differences between the experimental groups and control group in body image concern (p<0.001), anxiety (p<0.001), and depression (p<0.001). There were no significant differences between the behavioral activation and metacognitive therapy groups in depression (p=0.821) and anxiety (p=0.192). Still, there was a significant difference between behavioral activation and metacognitive therapy in body image concern (p=0.047). Behavioral activation was more effective in body image concern.

According to the result, behavioral activation therapy and metacognitive therapy have a significant effect on reducing body image concern, anxiety, and depression in psoriasis patients. The use of these therapies by therapists seems essential. Also, the effectiveness of behavioral activation therapy in reducing body image concerns is more than metacognitive therapy.

Psoriasis is a chronic skin disease that has many effects on patients' mental health. Therefore, the aim of this study was to evaluate the effectiveness of metacognitive therapy on body image concern, anxiety and depression in psoriasis patients.

This research was a quasi-experimental study with pretest-posttest and control group. Thirty people with psoriasis in Mashhad (Iran) selected by available sampling method and the randomly assigned to experimental and control groups. The experimental group underwent 8 sessions to metacognitive therapy, while the control group did not receive any intervention. The participants completed Body Image Concern Inventory (BICI), Hamilton Anxiety Rating Scale (HAM-A) and Beck Depression Inventory II (BDI-II). Data were analyzed by SPSS software, using multivariate analysis of covariance (MANCOVA).

The findings showed that there was a significant difference between experimental and control groups in body image concern, anxiety and depression scores (P< 0.05).

The results suggested that metacognitive therapy has a significant effect on reducing body image concern, anxiety and depression in psoriasis patients. Therefore, therapist can use this method to reduce body image concern, anxiety and depression in these patients.

Forkhead box P3 (Foxp3) gene is an important means in the Treg cells function, in both maintenances of immune tolerance and regulation of response. Epigenetic modifications of the foxp3 gene at its regulatory regions control the chromatin accessibility for the transcription factors and other transcriptional regulators in order to control Foxp3 expression. In addition, the methylation status of CpG islands within the Foxp3 promoter and regulatory elements regulate the expression of Foxp3. This study was performed to assess the role of the foxp3 gene in patients with Behçet’s syndrome (BS). Venous blood samples were collected from all participants and peripheral blood mononuclear cells (PBMC) were extracted through Ficoll-Hypaque method. Genomic DNA was randomly sheared by sonication and immunoprecipitated with a monoclonal antibody. The status methylation of the foxp3 gene was estimated in 108 blood samples of active BS patients and healthy individuals (controls); using methylation DNA immunoprecipitation (MeDIP) technique. Expression analysis was carried out; using Real-time PCR. The expression of foxp3 gene in the patients' group (mean±SD: 1.79±1.12) was significantly lower than the healthy group (mean±SD: 2.73±1.33) (p<001). Also, the methylation levels of Foxp3 promoter showed that its level in patients (mean±SD: 2.3±1.16) was higher than the healthy group (mean±SD: 1.85±0.59). However, this increase was not statistically significant (p>0.05). Also, these results indicated that increasing the amount of methylation of the foxp3 gene by reducing its expression leads to an increase and intensifying of the disease. The decrease in Foxp3 expression is possibly associated with hypermethylation of the gene, and it can be considered as a risk factor for BS. Future studies may be needed to identify the capability of specific DNA methylation alterations in this syndrome.