omid mohammaddoost

The increase in inflammatory markers, including TNF-α, contributes to the development and progression of cardiovascular complications. This study aimed to investigate the effects of six weeks of total body resistance training (TRX) and oral consumption of aqueous extract of mango leaves (Mangifera indica) on serum TNF-α level and body mass index (BMI) in overweight and obese non-athletic men.

In this semi-experimental study, 48 overweight and obese non-athletes aged 20 to 25 years were randomly assigned to four groups: control, mango leaf extract, exercise + placebo, and exercise + extract. For six weeks (three sessions per week), participants engaged in total body resistance training (TRX) and consumed aqueous mango leaf extract (two capsules of 500 mg per day). Serum TNF-α level were measured 24 hours before the first session and 48 hours after the last training session using the ELISA method. Additionally, measurements for weight, BMI, and waist-to-hip ratio (WHR) were recorded.

After six weeks of intervention, serum TNF-α levels significantly decreased in the exercise + placebo, exercise + extract, and mango leaf extract groups compared to pre-test values (P = 0.0001). In the post-test, both the exercise + extract and exercise + placebo groups, along with the mango leaf extract group, demonstrated a significant reduction in TNF-α levels compared to the control group (P < 0.001). Furthermore, body weight, BMI, and WHR were significantly reduced in the exercise + placebo and exercise + extract groups compared to the mango leaf extract and control groups (P < 0.001).

Six weeks of TRX training combined with the consumption of mango leaf extract may effectively reduce inflammatory markers such as TNF-α, as well as decrease BMI and WHR in young overweight and obese non-athletes. These findings suggest valuable insights for implementing effective exercise programs aimed at addressing obesity in young men.

Physical activity has a dual effect on inflammation and the results of studies are very contradictory. The aim of this study was the interactive effect of six weeks of TRX training and oral intake of mango tree leaf extract on interleukin-12 and anterometric indices of overweight and inactive obese male students.

In a semi-experimental research, 48 overweight and inactive obese students with an age range of 20-25 years were purposefully selected and divided into 4 groups of 12: control, extract, exercise and exercise+extract. For six weeks (three sessions per week), they did TRX exercises and took 500 mg capsules containing mango leaf extract twice a day lunch and dinner. Blood sampling was done 24 hours before and 48 hours after the last training session. Interleukin-12 serum level was measured by ELISA method using human kit. Data were analyzed with dependent t-test and one-way analysis of variance and significance level less than 0.05 in SPSS-25 software (P<0.05).

A significant difference was observed in the levels of interleukin-12 in the exercise, exercise+extract and extract groups compared to the pre-test (p=0.001). The pre- and post-test differences between the groups using one-way analysis of variance on weight, fat percentage, body mass index and interleukin-12 levels showed a significant difference between the research groups (p < 0.05 between groups).

Six weeks of TRX training and consumption of mango leaf extract may be effective in reducing weight, fat percentage, body mass index and interleukin-12 serum levels. On the other hand, one of the ways to control inflammation is to do TRX exercises with mango leaf extract.

The α-actinin-3 (ACTN3) gene plays a key role in muscle signaling pathways and sarcomere contraction. Iranian weightlifters are among the most successful world and Olympic champions. Therefore, the present study was performed to compare the genetic profile of the single-nucleotide polymorphism of the ACTN3 gene in elite Iranian male weightlifters vs. non-athletes.

This cross-sectional study was of a qualitative-quantitative type. Subjects included 30 volunteer elite male weightlifters, including all of Iran’s premier league, members of the national team, Olympic, world, and Asian champions of Isfahan province, with a mean age of 21.77 ± 7.11, the height of 179.87 ± 6.98, and the weight of 96.87 ± 22.73 (Mean ± SD) versus 30 volunteers available healthy non-athletes who were the same in age, height, and weight as weightlifters. After completing the consent form and physical health measurement questionnaire, participants’ saliva samples were collected, and DNA was extracted accordingly. Genotypes were determined after performing the polymerase chain reaction via the Tetra-Arms method and electrophoresis. Data were analyzed by SPSS (version 20) and the chi-square test (P < 0.05).

The prevalence of the RR genotype in selected weightlifters (56.7%) was significantly higher than that of other genotypes (χ2 = 13.40, P = 0.03). There was a significant difference in ACTN3 R/X genotype distribution (P = 0.039, χ2 = 6.48) between weightlifters and non-athletes.

A higher prevalence of the RR genotype of the ACTN3 gene in selected elite male weightlifters versus non-athletes can be likely considered for selecting genetically predisposed individuals.

Miners are exposed to different pollutions in mineral environments. This study aimed to investigate the pulmonary function and respiratory disorders in the workers of Nahbandan city caused by dust and dirt. The semi-experimental study was conducted on 30 workers with occupational exposure to dust (exposure group) and compared them with 30 workers without occupational exposure to dust. Two rounds of spirometry were performed for them after they completed a standard respiratory questionnaire. Data were analyzed using paired t-test and one-way ANOVA in the confidence level of p<0.05 in SPSS-22 software. The clinical symptoms pulmonary in the exposure group were significantly higher than the clinical symptoms pulmonary in the group without exposure (p<0.05). Pulmonary function was significantly lower in the exposure group than in the without exposure group (p<0.05). The second Spirometry showed that the average of all parameters at the end of the work shift was decreased compared to the corresponding values before exposure. These values were not considerable (p>0.05), but the average of inhalable dust in mines was 1.75 times the allowable occupational contact in Iran. Stone mine dust is associated with irreversible chronic changes in pulmonary function parameters and respiratory symptoms. Consequently, all workers must wear special masks at work, and the daily work schedule should be reduced.

N-methyl D-aspartate (NMDA) is one of the leading causes of synaptic formability. This study aimed to investigate the effect of ginseng supplementation and aerobic exercise on NMDA levels in non-athlete female students.

 In this quasi-experimental study, the statistical population included all female students aged 15 to 18 years in Zahedan. Among the eligible individuals, 48 were selected voluntarily and purposefully and were randomly divided into four groups: "Exercise," "Exercise + Supplement," "Supplement," and "Control." The training protocol included six weeks of running in the gym for 25 to 40 minutes. Exercise intensity was 60 to 70% of the reserve heart rate. Subjects in the supplement groups received 500 mg of ginseng daily (250 mg in the morning and 250 mg in the afternoon). In the pre-test stage, five ccs of blood were taken from the right arm vein of each subject. Then, 48 hours after the end of the intervention (end of the sixth week), sampling of the participants was repeated in conditions similar to the pre-test stage. ELISA measured plasma NMDA levels. Data were analyzed by two-way analysis of variance, Bonferroni post hoc test, and paired t-test, and the significance level of P<0.05 was considered.

 N-methyl D-aspartate levels increased significantly after six weeks of aerobic exercise and ginseng supplementation in the exercise + supplement group compared to the other groups. In addition, the levels of NMDA in the same group (Exercise + Supplement) showed a significant increase compared to the pre-test after six weeks of exercise and ginseng supplementation (p=0.001). Also, the N-methyl D-aspartate index increased in the exercise, Exercise+Supplement, and supplement groups compared to baseline values (p=0.001). In contrast, no change in this index was observed in the control group.

 Aerobic exercise and ginseng supplementation significantly improve N-methyl D-aspartate level in non-athlete girls.

Trampoline rebound is one of the recent interesting exercises. The present study aimed to investigate the effect of six weeks of trampoline rebound exercises on cardiovascular indices, body mass index, and lipid profile of obese and overweight women.

The statistical population of the present quasi-experimental study consisted of 20 obese and overweight women in Zahedan ( (BMI) ≤27.5 kg/m2), and randomly assigned to two groups of exercise (n=10) and control (n=10). The subjects participated in four 90-min sessions of rebound trampoline exercises for six weeks using a trampoline mat. Physiological, BMI, and lipid parameters were measured in two stages of pre-test and post-test. Data were analyzed in SPSS software (version 21) using independent and dependent t-test, as well as an ANCOVA test. A p-value less than 0.05 was considered statistically significant.

The results demonstrated a significant decrease in post-test values ​​of LDL (from 92.90±1.52 to 73.10±3.81), cholesterol (from 182.10±1.96 to 166.30±6.32), triglyceride (from 108.30±1.33 to 95.30±5.35), and body mass index (29.44±1.07 to 27.38±1.02), as well as a significant increase in HDL (from 59.60±2.75 to 77.00± 3.09) and Vo2max (from 45.50±1.31 to 57.80±1.31) in posttest of the training group, compared to their pre-test (P<0.05). Furthermore, there were the same changes in these parameters in the exercise group, compared to the post-test values ​​of the control group (P<0.05).

As evidenced by the results of this study, six weeks of trampoline rebound training had beneficial effects on controlling lipid profile, cardiovascular indices, and body mass index of obese and overweight women. This training protocol is suggested to improve these indicators in the same groups with obesity and overweight, especially for the variety of exercises.

Exercise along with sutible diet and medication are the basic methods of treating type 2 diabetes. The present study aimed to investigate the effect of aerobic exercise and isoflavone soy supplementation (Glycine soja) on changes in hemoglobin A1C and fasting blood sugar in type 2 diabetic patients.

In this semi-experimental study, 56 men and women with type 2 diabetes referred to Zahedan Dietetic Clinic with a range of 25-35 years through targeted sampling and randomly in four groups (of 7 females and 7 males) were divided into aerobic supplementation, aerobic exercise, supplementation, and diet. The study lasted 12 weeks and aerobic exercise. One Isoflavone soy tablet (50 mg) was given daily. The diet of all groups was 5% lower calorie restriction and 10% daily energy increase. Blood sampling was performed 24 hours before and 48 hours after the intervention. SPSS-22 software and dependent T-statistical methods and one-way analysis of variance at a significant level (P<0.05) were used to analyze the data.

In all four groups, FBS and HBA1C factor of men and women decreased significantly (P<0.05), but in the FBS factor men compared to the intergroup, all four groups had a significant difference (P <0.05).

Aerobic exercise and soy isoflavone supplementation (50 mg daily) improve the risk factors for type 2 diabetes. Therefore, exercise and consumption of soy isoflavone supplement can be used as an alternative to drug therapy in the recovery of patients with type 2 diabetes, but this issue needs more and more accurate research.

The aim of this study was to evaluate the effect of six weeks of TRX training and curcumin consumption on muscle injury indices in female athletes.

This quasi-experimental study was performed on 36 healthy female athletes with an age range of 18-25 years and a body mass of 18.5.5 kg / m2. Subjects were purposefully selected and randomly divided into three groups of 12 people including exercise + placebo, exercise + curcumin and curcumin. The training protocol consisted of six weeks of TRX training (three sessions per week; eight sessions per session). Curcumin supplementation is also given in the form of 500 mg capsules daily after lunch. Data were analyzed by paired t-test and one-way ANOVA at a significance level of 0.05 with Spss-22 software.

Posttest values ​​related to creatinine index were significantly reduced in the exercise + placebo (P = 0.02) and exercise + curcumin (P = 0.03) groups. Also, this decrease in lactate dehydrogenase index was observed in the mentioned groups (P = 0.04 and P = 0.04, respectively). There was a significant difference between exercise + placebo group and curcumin group in creatine kinase (P = 0.00), lactate dehydrogenase (P = 0.02) indices. Also, a significant difference was observed between the exercise + curcumin group and the curcumin group in the indices of creatine kinase (P = 0.00) and lactate dehydrogenase (P = 0.05).

To reduce muscle injuries, TRX training can be used as an effective method to reduce pain and bruising after exercise. In addition to this exercise method, taking curcumin herbal supplement is effective in faster recovery of pain and contusion after exercise.

Puberty is affected by obesity. The aim was to investigate the interactive effect of stevia aqueous extract consumption and aerobic exercise on insulin resistance index and body composition of obese boys and girls during puberty.

Semi-experimental research; 60 obese boys and girls aged 12-17 years who were divided into four groups: aerobic exercise, stevia, aerobic exercise + stevia, and control. Fasting glucose and insulin levels were measured and the insulin resistance index was calculated by the HOMA-IR method. Subjects practiced three sessions a week for 12 weeks with an intensity of 60 to 85% of maximum heart rate. Supplement for 12 weeks daily 12 cc of the water-soluble extract was taken 3 times after the main meal. Data were analyzed by paired t-test, one-way analysis of variance, and Bonferroni test at the significant level of p

The decrease in body mass index, body fat mass, insulin, and serum glucose as well as the increase in net body mass in the aerobic + stevia exercise group were significant in girls and boys (p < 0.05). HOMA-IR reduction was significant in all groups except the control group, but there was no significant difference between the changes in the two groups of aerobic exercise and control.

Aerobic exercise and consumption of aqueous stevia extract made favorable changes in the subjects' HOMA-IR and body composition, but some of these changes are due to the natural growth process during puberty.

Activity has turned away from the human body by machine life and has replaced with obesity. This study aimed to investigate the interactive effect of eight weeks combined training and curcumin consumption on serum levels of interleukin-12 and some anthropometric indicators in obese sedentary woman.

Semi-experimental study, Forty-eight obese women with an age range of 20-30 years were purposefully selected and divided into four groups of 12 people: control, curcumin, exercise and exercise+curcumin and for eight weeks to do combination exercises (aerobic exercise with an intensity of 60 to 80% of the MHR and resistance training with an intensity of 55 to 75% of a maximum repetition) and daily intake of curcumin of 80 mg. Fasting blood samples were taken before and after the last training session and interleukin-12 levels were measured by ELISA using kits. Data were analyzed using dependent t-test and one-way analysis of variance and significance level less than 0.05 in SPSS-22.

There was a significant difference in levels of interleukin-12 and body mass index between the groups of exercise, exercise+curcumin and curcumin consumption compared to the pretest (p<0.05 intragroup). The difference between pre- and post-test group differences on levels of interleukin-12 and body mass index was significantly different between the research groups (p<0.05 between groups).

Eight weeks of combined training and curcumin consumption had a significant change in levels of IL-12. Physical activity causes weight loss and thus a decrease in body mass index, but the consumption of curcumin alone does not change the anthropometric indicators of individuals.

This study aimed to compare the effect of two types of core stability and balance training program on the semi-dynamic balance of non-athlete girls.

This quasi-experimental pre and post-test on 36 healthy female student-athlete with a mean age 20/32+0/9 in three groups (11 people controls group, 12 people in central sustainability group, 13 people in equilibrium group) Was performed The subjects in the two groups practice their training program conducted 2 sessions per week for 4 weeks. Before and after the training period, semi dynamic balance of subjects were evaluated using the Biodex system. After collecting and importing data into environment of SPSS 20.0 software, using statistical methods, the Kolmogorov-Smirnov test for normality of the data and the analysis of variance the three groups were evaluated. ANOVA and Tukey's test was used to compare changes within the group and between groups

Compare the results of the test balance, represents a significant difference in the overall index and anterior posterior of non-athletic girls that this meaningful comparison of the group, in favor of sustainability is central.

According to the findings, it can be said that the core stability exercises appropriate method to enhance and improve balance. Hence it is necessary to develop a training program lasting central part of the semi-dynamic balance of functional (performance).