جستجوی مقالات مرتبط با کلیدواژه "آسپروزین" در نشریات گروه "علوم انسانی"

Inflammatory factors are known as an important mechanism in the occurrence of type 2 diabetes and metabolic diseases; while regular exercise has anti-inflammatory effects and suppresses low-grade systemic inflammation in type 2 diabetes. Therefore, the present study was conducted with the aim of investigating the effect of combined exercises with stevia supplementation on serum levels of asprosine, glucose and insulin resistance in obese women with type 2 diabetes.

60 women with type 2 diabetes voluntarily participated in the study and were randomly divided into four groups. The subjects of the exercise group participated in selected sports exercises for 12 weeks and three sessions a week. One gram of stevia extract was taken daily, 15 minutes before the main meal. Fasting blood glucose, HbA1C, insulin resistance index and asprosin serum levels were measured.

The results of analysis of variance showed that there is a significant difference between the effects of different interventions in the serum levels of asprosine, blood glucose levels, HbA1C and insulin resistance. Combined exercises with stevia supplementation led to a decrease in the serum levels of asprosine in the exercise, supplement, exercise+supplement groups (p<0.001). But these changes were more significant in the exercise + supplement group.

It seems that both intervention methods of combined exercises and stevia supplementation are effective methods in controlling blood sugar and reducing inflammation, and the combination of these two methods is more effective in controlling glycaemia in patients with type 2 diabetes.

Asprosin is a protein hormone that is mainly secreted by fat cells and enters the bloodstream. In the present study, the effect of 8-week continuous training was investigated on serum levels of asprosin, insulin, and insulin resistance index in obese rats.

For this, 32 male Wistar rats (mean weight=180/23±7 grams) were randomly divided into four groups of Healthy Control (N=8), Obese Control (N=8), Healthy Training (N=8), and Obese Training (N=8). The continuous training group performed the training protocol for 8 weeks, and 48 hours after the end of the last training session, the rats were anesthetized and euthanized. The variables of interest (serum levels of asprosin, level of glucose, insulin, and insulin resistance index) were measured in rats. Data analysis was performed using the Kruskal–Wallis test at the significance level of α=0.05.

There was a significant difference among mean serum levels of asprosin (p<0/001), insulin (p<0/001), fasting glucose (p<0/001), and insulin resistance index (p<0/001) in the Healthy Control, Obese Control, Healthy Training, and Obese Training groups.

Based on the results of the present study, it seems that obesity has a significant effect on increasing asprosin levels and continuous exercise has a significant effect on reducing asprosin levels. Therefore, continuous training can be used as an important strategy to reduce asprosin levels and weight.

Type 2 diabetes is a risk factor for heart disease and has a major contribution in mortality due to cardiovascular diseases. In diabetics people, high levels of glucose is a very important issue that should be controlled. In the present study, the effect of 8-week HIIT was investigated on Serum levels of Asprosin, insulin, and insulin resistance index in diabetic rats. In this Investigation, A total of 32 male Wistar rats (mean weight, 180/23±7gr) were randomly divided into four groups of Healthy control (N=8), diabetic control (N= 8), Healthy training (N= 8) and Diabetic training (N= 8). The training group performed a 8-week High Intensity Interval Training, and 48 hours after the end of the last training session, the rats were anesthetized and euthanized. The variables of interest (Serum Levels of Asprosin, level of glucose, insulin, and insulin resistance index), were measured. Data analysis was performed using Kruskal–Wallis at significance level of p≤0.05.There was a significant difference among Asprosin (p>0/001), level of glucose (p>0/001), insulin (p>0/026), and Insulin Resistance Index (p>0/001) between the Healthy control Group, diabetic control Group, Healthy training Group and Diabetic training Group. According to the results of the present study, it seems that High Interval Intensity Training is an important strategy to decrease Asprosin, plasma glucose and Insulin resistance index in diabetics rat and it can be considered as an effective intervention method for treatment diabetes.

Asprosin is a counter-regulatory protein hormone of insulin and is associated with chronic diseases such as obesity and diabetes. Therefore, the aim of this study is to investigate the effect of aerobic exercise on the expression of the asprosin gene in the pancreatic tissue of male rats with diabetes.

32 male Wistar rats were randomly divided into 4 groups: control (n=8), exercise (n=8), diabetes (n=8), and diabetes+exercise (n=8) after inducing diabetes with STZ. After getting familiar with the training protocol, the rats in the training group performed the aerobic training protocol 5 times a week for eight weeks. After completing the protocol, pancreatic tissue was extracted and RT-PCR method was used to measure RNA and ELISA method was used to measure asprosin protein expression. Analysis of variance test was used to analyze the data (P<0.05).

The results showed that induction of diabetes significantly increases the expression level of asprosin gene and protein in pancreatic tissue (P<0.001). Eight weeks of aerobic training significantly reduced asprosin protein expression in the exercise group (P=0.019) but the decrease in gene and protein expression of asprosin in the diabetes+exercise group was not significant compared to the diabetes group.

Aerobic exercise reduced the level of asprosin in pancreatic tissue, which was increased due to diabetes, but was not able to return it to its original level. It seems that the effect of exercise is independent of the cellular and molecular pathways in the pancreatic tissue and plays a role mostly through the cell signaling pathways in the muscle, and in the damaged cells of the pancreatic tissue due to diabetes, in relation to asprosin addition to exercise, it is necessary to other treatment methods.