جستجوی مقالات مرتبط با کلیدواژه « هیپوکمپ » در نشریات گروه « تربیت بدنی »

Exercise and training can maintain the health and plasticity of the nervous system. Tropomodulin-2 (Tmod2) plays an important roles in the central nervous system and it correlated with various functions such as the formation of new synapses and increased neuritis extension. The aim of this study was to evaluate the effect of low-intensity endurance training on Tmod2 protein levels and Malondialdehyde (MDA) in the hippocampal tissue of male Wistar rats.

For this experimental research, 20 rats were randomly divided into two groups including training (n=10) and control (n=10), that for the training group, the endurance training program was run for six weeks at 20-40 percent of maximum running speed. Forty eight hours after the last training session, the rats were dissected and hippocampal tissue was extracted. Immunohistochemistry and Elisa methods were used for measuring the expression of Tmod2 protein and MDA respectively. Independent t-test was used to compare the groups at the significant level of p<0/05.

Based on the results, low-intensity endurance training significantly increased the expression of Tmod2 protein (p=0.01) but the MDA concentration (p=0.001) reduced during training as compared to the control group.

Endurance training showed a beneficial effect on Tmod2 and also the nervous system; however, reducing the concentration of MDA can be considered as a decreasing of the oxidative stress; a change that shows the protective effects of this training method against oxidative stress.

The purpose of this study was to investigate the effect of sprint interval training on hippocampal oxidative stress markers hippocampus of adult male Wistar rats. This is an experimental study in which 16 male Wistar rats were obtained, and after environmental adaptation and reaching target weight range randomly divided into two equal groups: control (CO) and sprint interval training (SIT). The SIT was performed for 8 weeks, 3 sessions per week, 4-9 repetitions of 10 seconds with 60 secs of active recovery between intervals. Forty-eight hours after the last exercise session the rats were anesthetized and the hippocampus was dissected and level of malondialdehyde (MDA) and superoxide dismutase (SOD), glutathione peroxidase (GPx), and total antioxidant capacity (TAC) were assessed in hippocampus homogenate. The independent samples T test was used for data analysis (P<0.05). There were no significant difference between the SIT and CO groups in the hippocampal GPx, TAC and MDA levels (p < 0.05). However, the activity level of SOD in the SIT group was significantly higher than the CO group (p<0.05). The present research revealed that despite its strenuous nature, SIT did not induce oxidative stress in the hippocampus and trend of changes in GPx and TAC, as well as observed significant increase in SOD activity levels suggests that it may have favorable effects on hippocampus oxidative- antioxidative status.

Aging is an important risk factor for cognitive functions. On the other hand, exercise improves brain health and improves cognitive functions. However, the mechanisms of these benefits have not yet been fully elucidated. Therefore, the present study was conducted with the aim of investigating the effect of four weeks of intermittent aerobic exercise with moderate intensity on cognitive function and the expression level of PGC1α and VEGF genes in the hippocampus of old rats. For this purpose, 20-month-old male Wistar rats were divided into 2 exercise training groups (number = 8 heads) and control (number = 8 heads). The animals of the sports group performed intermittent aerobic training with moderate intensity for 4 weeks, 5 days a week. In order to investigate learning and spatial memory, the animals were subjected to the Morris water maze test 48 hours after the last training session. Then, the animals were killed and the hippocampal tissue was extracted. Real time-PCR method was used to measure gene expression. Statistical analysis was done using independent t-test and Pearson's correlation coefficient at a significant level of P£0.05. The results showed that aerobic exercise improved learning performance (P ≥ 0.05) and spatial memory (P ≥ 0.001) and the expression level of PGC1α (P ≥ 0.01) and VEGF (P ≥ 0.001) Increasing. Also, a significant positive correlation between PGC1α gene expression and VEGF gene expression in the hippocampus was observed (p≥0.001, r=0.894). In addition, there was a significant inverse relationship between VEGF gene expression and the average time spent to find the platform (p≥0.05, r=-0.578), and there was a significant positive relationship with the time spent in the quadrant of the target circle (p≥0.01, r=0.713). In general, aerobic exercise improves learning performance and spatial memory in old animals; It seems that exercise-induced upregulation of the PGC1α/VEGF signaling pathway in the brain is at least partially involved in this adaptation.

  Today, the use of energizers has become a complex problem in sports. On the other hand, resistance training and Tribulus terrestris have a great effect on controlling oxidative stress, but the interaction of resistance training with Tribulus terrestris and Stanazol on low antioxidant capacity. More reviewed. Therefore, the aim of this study was to investigate the effect of eight weeks of resistance training with consumption of Tribulus terrestris extract on the levels of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) in the hippocampal tissue of male rats exposed to stanazol.

In this experimental study, 56 male rats with a weight range of 150 to 200 g and a mean age of 8 weeks were selected and included in 7 groups of 8 series including 1) control (C), 2) stanazol (S), 3) stanazol with 100 mg / kg of tribulus terrestris (ST100), 4) Taking Stanazol with 50 mg / kg of tribulus terrestris (ST50), 5) Taking Stanazol with resistance training (SRT), 6) Taking Stanazol with resistance training and 100 mg / kg of tribulus terrestris (SRTT100) and 7) Taking Stanazol with training Resistance and 50 mg / kg of tribulus terrestris (SRTT50) were divided. For eight weeks, the 2-7 groups received 5 mg / kg daily of stanazole peritoneally;  Groups 5-7 performed resistance exercises three sessions a week with an intensity of 30 to 100% of their body weight and groups 3, 4, 6 and 7 received certain doses of tribulus terrestris daily.  One-way analysis of variance with Tukey post hoc test was used to analyze the findings (p <0.05).

Consumption of S had a significant effect on reducing SOD, GPX and CAT levels in rat hippocampal tissue (P<0.05), however, SRT significantly increased SOD, GPX and CAT levels (P<0.05), as well as ST50 and ST100. They had a significant effect on increasing SOD and GPX levels (P<0.05). SRTT100 and SRTT50 had a significant effect on increasing SOD, GPX and CAT levels (P<0.05). SRTT100 had a greater effect on increasing SOD levels (P<0.05), while CAT levels had a greater increase in SRTT50 (P<0.05).

 It seems that resistance training and consumption of tribulus terrestris separately have effective effects on improving antioxidant indices, however, resistance training and consumption of tribulus terrestris supplementation can have more favorable effects than any intervention alone on Have antioxidant properties of hippocampal tissue due to stanazole poisoning.

Exercise can causes neurogenesis in the brain of adult mammals. Until now few studies investigated how the effect of exercise on neurogenesis. The aim of the present study was examine the effect of the running time on cell proliferation in the hippocampus of adult male rats.

Eighteen adult male rats following one week of familiarization with treadmill were randomly divided into three groups including of control group (n=6), 30-min running group (n=6) and 60-min running group (n=6). The animals in running groups were subjected to daily 30-min and 60-min treadmill exercise sessions with velocity of 12 meter per minute for 14 consecutive days. At the last 10 days, animals received daily injections of bromodeoxyuridine (BrdU) in a specific dose to label dividing cells. After 48 hours of the last session of running, the animals were sacrificed and their brain was removed for immunohistochemichal analysis. The one-way analysis of variance followed by least significant difference (LSD) post hoc test was used to analyze the data at the significant level of p<0.05.

The number of Brdu+ cells increased significantly both after running for 30 (p=0.001) and 60 (p=0.001) minutes; so that these changes were significantly higher after the 60-min than to the 30-min running (p=0.001).

The results of this study showed that running regardless of time traveled per day increases cell proliferation in the hippocampus of adult male rats; so that the longer the time, the greater the rate of cell proliferation.

One of the cause of adaptations due to exercise training is increased capillary density or angiogenesis. increased blood flow to hippocampus tissue causes improvement of memory, learning and neurogenesis process and prevention from accession brain disease like Alzheimer. The Aim of this study was to compare the effect of Eight weeks resistance and Endurance running on VEGF-A and FGF-2 levels of hippocampus tissue in male Wistar rats.

This study in aim perspective was developmental and in method perspective was Experimental. For this aim 32 male Wistar rats, divided randomly in four groups (Resistance Training, Running, Sham and control) and training groups exercised for eight weeks. For evaluation of VEGF-A and FGF-2 concentrations of hippocampus tissue used from sandwich Elisa method and for hypothesizes test from one-way ANOVA and Tukey post hoc used.

Results show that Eight weeks’ resistance and endurance training Respectively cause significant increase in VEGF-A (P = 0.000), (P = 0.000) and FGF-2 (P = 0.000), (P = 0.000) than to control group. Also there are significant different in concentrations of VEGF-A (P = 0.000) and FGF-2 (P = 0.000) of hippocampus tissue between resistance and endurance running groups. In addition, no significant differences was observed in VEGF-A (P = 0.982) and FGF-2 (P = 1.000) indexes between exercise sham and control groups.

Results of this study show that eight weeks’ resistance training cause more significant increase on effective angiogenic factors in hippocampus tissue of male Wistar rats than endurance running training group.

The aim of the present study was to investigate the effect of different training periods on beta-amyloid 42 index in the hippocampus of streptozotocin-induced diabetic male rats. For this purpose, 84 male Wistar rats weighing 281± 28 g were randomly divided into 4 groups of 21. Subjects were divided into control, exercise, diabetes, diabetes and exercise groups. Simple variance analysis and repeated measures analysis of variance were used to investigate the changes of beta-amyloid 42. The results of analysis of variance in repeated measures showed that there was a significant difference in beta-amyloid 42 at different stages (8, 4 and 12 weeks of training) (P = 0.001). Multiple Bonferroni comparisons revealed that the levels of beta-amyloid 42 were significantly different during all stages of exercise (4 weeks (P = 0.37), 8 weeks (P = 0.001) and 12 weeks (P = 0.001)).In general, it can be concluded that in all 3 different times (4, 8 and 12 weeks) the amount of beta-amyloid 42 in the control and diabetes groups was higher than the exercise, diabetes and exercise groups, respectively. In diabetes, over time (from 4 weeks to 8 and then 12 weeks) the amount of beta-amyloid 42 increases and continuous aerobic training reduces this variable.

The aim of the present study was to investigate the effect of 4 weeks of aerobic exercise on cognitive function and mitochondrial dynamics in the hippocampal tissue of male Wistar rats with Alzheimer's disease.

For this purpose, 21 male Wistar rats at 20 months of age were randomly divided into 3 groups: Alzheimer's disease (n = 7), Alzheimer's disease + aerobic exercise (n = 7) and control group (n = 7). Alzheimer's disease was induced by intrahippocampal injection of Aβ42 (1 microliter per side). Seven days after surgery, the exercise group performed 4 weeks of treadmill training (5 days per week at a speed of 10 to 15 m/min). Forty-eight hours after the last training session, the animals underwent behavioral tests. Twenty-four hours after the behavioral test, all rats were killed and hippocampal tissue was extracted. The mRNA expression of OPA1, Mfn2 and Drp1 genes was assayed using Real Time-PCR. One-way analysis of variance was used for statistical analysis. Ethical Considerations: All stages of the study were conducted according to the ethical guidelines and authorization of Research Deputy of Islamic Azad University, Central Tehran Branch No. IR.IAU.TMU.REC.1399.124.

The results showed that spatial learning (P ≤ 0.001) and memory performance (P ≤ 0.001) as well as the gene expression of OPA1 (P ≤ 0.001) and Mfn2 (P ≤ 0.001) in animals with Alzheimer's disease decreased compared to the control group, while the gene expression of Drp1 increased (P ≤ 0.001). Aerobic exercise in patient animals improved spatial learning (P ≤ 0.001) and memory performance (P ≤ 0.001), increased hippocampal OPA1 (P ≤ 0.001) and Mfn2 (P ≤ 0.001) genes expression, and decreased Drp1 gene expression compared with Alzheimer's disease group (P ≤ 0.001).

In general, it seems that aerobic exercise can improve spatial learning and memory performance in Alzheimer's disease by modulating abnormal mitochondrial dynamics. کلیدواژه‌ها [English]

Running causes increments in synaptic plasticity in the adult brain. However, the effect of types of running on plasticity-related molecular changes are not well documented. The purpose of this study was to determine the effect of two types of endurance training on brain derived neurotropic factor (BDNF) and tyrosine kinase B receptor (TrkB), in the hippocampus of adult male rat.

In this experimental study 18 adult male wistar rats, 8 weeks of age were randomly and equally (n=6) divided into 3 groups of control, continuous running and interval running. Animals in training groups were allowed to run on treadmill with intensity of 12-23 meter per min and 3 days a week for 8 weeks. Changes in protein levels of variables were determined by ELISA technique. In order to extract of the results, the one-way analysis of variance and LSD post hoc test were used at a significant level of p≤0.05.

The values of BDNF (p=0.01) and TrkB (p=0.0001) in the continuous running group showed a significant increase compared to the control. Also, in the interval running group, a significant increase was observed in both variables, BDNF (p=0.003) and TrkB (p=0.0001), but no significant difference was observed between the two training groups.

Endurance training (as running) leads to increases in the BDNF and TrkB in hippocampus regardless of its type. Since these two biomarkers are the main factors in hippocampal plasticity, memory and learning processes; increasing their protein levels after endurance running shows the positive effect of these factors on the mentioned processes in adults.

The increase of proteins related to blood supply in the hippocampus tissue following swimming exercise can probably prevent the occurrence of brain diseases such as Alzheimer's. The aim of the present study was to determine the effect of eight weeks swimming exercise training on VEGF-A and FGF-2 levels of hippocampus tissue and Lee's Index in male Wistar Rats.

16 male Rats, divided randomly into 2 groups (swimming exercise training and control). Swimming training group exercised for 8 weeks, 5 consecutive days per week for 60 minutes in water with 32±2˚C of temperature. for evaluation of VEGF-A and FGF-2 Levels used from Elisa Method, To measure Lee's index from height and weight measurements and for hypothesizes test used from Independent T Student, Mann - Whitney U and Wilcoxon tests in level of p≤0.05.

Results show that eight weeks swimming training cause significant increase in VEGF-A (P=0.002) and FGF-2 (P=0.000) in hippocampus tissue compare to control group. Furthermore Eight weeks Swimming training cause significant decrease in Lee's index and improvement of mass index in Rats (P=0.012).

Results of this study show that eight weeks swimming exercise training cause increase on effective angiogenic factors in hippocampus tissue and improvement of mass index in male Wistar Rats

Although the beneficial role of exercise in the health of patients with Alzheimer's (AD) has been reported, the mechanism of these effects on neuronal function in these patients is still not well understood. Therefore, the present study was designed to compare the effect of high intensity interval training (HIIT) and exercise in motor enriched environment (RE) on the expression of irisin and adiponectin proteins in the hippocampal tissue of Alzheimer's rats.

In this experimental study, 25 rats were divided into (1) control, (2) sham (Sh), (3) streptozotocin Alzheimer's model (AD) (4) high intensity interval training (HIIT) and (5) Exercises in motor enriched environment (RE). The HIIT group trained for eight weeks, five sessions per week and each session in 90 seconds practice in 9interval with an intensity of 85% of maximum speed, and the RE group were placed in especially motor enriched cages. In order to confirm the Alzheimer's model, thioflavin staining was used. One-way ANOVA with Tukey’ s post-hoc test was used for data analysis (P≤0.05).

The RE exercises significantly increased in irisin levels compared to the Alzheimer's group (P=0.0009), HIIT exercises resulted in no significant change in irisin levels. None of the training methods caused significant changes in adiponectin level (P>0.05).

Activity in an enriched motor environment through the irisin mechanism has more desirable effects in reducing AD symptoms

Mitochondrial transcription factor A (Tfam) has a key role in keep of copy numbers and transcription activity of mtDNA. The object of the recent study was to determine the effect of exercise training on serum levels and gene expression of mitochondrial transcription factor A and PGC1α in hippocampus of male rats. In the present study 20 Wistar rats were divided into training and control groups. Training protocol was done 60 min in each session for four sessions in each week. Training group was carried out 15 × 4 min bouts of training with 85 to 90% of VO2max that sustained with three min recovery with 70% of VO2max. PGC1α and Tfam and their gene translations were evaluated by commercial kits and Real-Time PCR method, respectively. Results illustrated that VO2max and serum levels of biomarkers of mitochondrial biogenesis were significantly increased (p<0.05). Also, PGC1α and Tfam gene translations in hippocampus were significantly increased (p<0.05). It seems that, the present three-week training protocol has competency to increase in both hippocampus and serum levels of PGC1α and Tfam in male rats. Likewise, there is a likelihood that significant increase of Tfam is due to meaningful vicissitudes of PGC1α.

This study was designed to investigate the effects of two models of training with different days of rest-to-training ratios of high-intensity interval training (HIIT) and natural honey supplementation on serum interleukin-6 (IL-6) and its expression in the hippocampus of immature Wistar rats. Thirty-six male rats were randomly assigned into six groups: control; honey (10% in drinking water); 4-day strenuous interval training; 4-day strenuous interval training+honey; 7-day strenuous interval training; and 7-day strenuous interval training+honey. They underwent HIIT (from 10-16 m/min in the first week to 36-40 in the last week) during 4-day (three days training, one day rest) and 7-day (six days training, one day rest) models for a month. Results demonstrated that the serum concentration of IL-6 was significantly (P=0.001) higher in the 7-day program in comparison with the control group.  Supplementation with honey in the 7-day group resulted in a lower level of serum IL-6 compared with 7-day group alone (P=0.018). There was no significant difference between four days and control groups (P=0.946). Both 7-day (P=0.007) and 4-day (P=0.005) training programs lead to a significantly higher level of gene expression of IL-6 in the hippocampus. However, honey supplementation didn’t modulate hippocampal gene expression in 4-day-honey (P=0.983) and 7-day-honey groups (P=0.583). Therefore, HIIT increases hippocampal gene expression of IL-6; however, longer period of training cause increase systemic inflammatory cytokines. Although honey supplementation couldn't adjust the central effect of the intensive interval training, it can ameliorate systemic inflammation. Also, honey hasn't anti-inflammatory effect in non-training and non-inflammatory conditions.

The aim of this study was to find answers to these questions: can exercise increase neurogenesis and does neurotrophic factor that is necessary for neurogenesis increase with training?30 rats were divided into four groups: young control, young training, middle-aged control and middle-aged training. The training was performed with overload principle for 6 weeks and 6 sessions per week. Young rats ran with the speed of 27 m/min. and the middle-aged rats with the speed of 20 m/min. for 20 minutes on the first day. The running time increased 2 minutes every day until it reached 60 minutes per day. Elisa method was used to measure the factors and they were analyzed by Tukey post hoc test.There was no significant difference in weight between young groups (sig=0.979) but the difference was significant between middle-aged groups (sig=0.000). Ki67 in young and middle-aged training groups was significantly more than control group (sig=0.002) and (sig=0.037). Midkine did not have a significant increase in the young training group compared with the young control group (sig=0.134). This factor increased in middle-aged training group but this increase was not significant (sig=0.557). The correlation between ki67 and Midkine was significant (r=0.407) (sig=0.029).Continuous training can increase the neurogenesis in young and middle-aged rats. This type of training may be useful to increase neurogenesis and its essentials (i.e. neurotrophic factors).

Cytoplasmic transport is a vital process in the CNS that improves neuronal survival. KIF5B and Dynein are motor proteins involved in cytoplasmic transport which play an important role in the anterograde/retrograde transport. However, the effect of training especially high intensity interval training (HIIT) is less clear on the expression of these proteins. The present study examined the effect of HIIT on the gene expression and the amount of KIF5B and Dynein proteins in the hippocampal tissue of Wistar male rats. 14 rats were divided into 2 groups: (1) the training (TG: n=7) and (2) the control (CG: n=7). Training program was carried out on a treadmill for 6 weeks, 5 sessions per week. The protein contents of KIF5B and Dynein were determined by the immunohistochemical analysis. Moreover, the Real-Time polymerase chain reaction (Real-Time PCR) procedure was used to measure mRNA expression of the variables. The findings showed that 6 weeks of HIIT significantly decreased the gene expression of KIF5B and Dynein (P=0.001 and P=0.001 or percentage of changes= -0.72 respectively). Also, HIIT significantly decreased KIF5B (P=0.001) and Dynein (P=0.004) protein content after 6 weeks of HIIT. These findings demonstrated that HIIT was associated with the down-regulation of gene expression and protein content of KIF5B and Dynein in the hippocampal tissue although the underlying mechanisms have remained unknown. These changes show that HIIT may have negative effects on anterograde/retrograde cytoplasmic transport because the cytoplasmic transport is mediated by KIF5B and Dynein.

Exercise through BDNF induces its beneficial effects on the brain. However, its cellular mechanisms are not fully understood. Thus, the purpose of this study was to investigate the effect of 8 weeks interval aerobic training on mRNA expression of SIRT1, CREB and BDNF genes in the hippocampus of male Westar rats.

Twelve 8 week old rats were the subjects of this study rats were randomly divided into two groups: exercise group and control group animals in the exercise group experienced interval aerobic exercise for 8 weeks (5 sessions per week at a speed of 10 to 15 m/min). Forty-eight hours after the last training session, animals were sacrificed and hippocampal tissue was extracted. mRNA expression of SIRT1, CREB and BDNF genes was determined by the real-time PCR method. An independent t-test was used to compare groups and significant differences were considered at the P≤0.05 level.

The results showed that the expression of SIRT1, CREB and BDNF mRNA levels in hippocampal tissue of the exercised group were significantly increased (P ≤0.001).

Overall, it appears that interval aerobic exercise is able to upregulate brain BDNF levels through the SIRT1/CREB/BDNF signaling pathway hence, this type of exercise training can be used to induce the beneficial effects of exercise on brain health.

The propose of this study was to evaluate the effect of aerobic training and exposure to PM10 carbon black on IL-6 mRNA expression in the hippocampus and frontal cortex of male Wistar rats. Twenty-four adult male Wistar rats (8-10 weeks age) were randomly divided to 4 groups: A: Control (n=6), B: Aerobic training (n=6), C: Exposure to Carbon black (n=6), and D: Aerobic training plus exposure to Carbon black (n=6). In order to exposure the animals to carbon black particles with diameter less than 10 microns was used particle injection device and chamber (Falunak). The rats of air pollution and air pollution-aerobic training groups were exposed to PM10 carbon black for four weeks (five days per week, two hours per day). After that, the rats of air pollution-aerobic training and aerobic training groups were carried out aerobic training program with 50% of own maximum speed for 4 weeks (60 minutes per session). The animals were sacrificed 24 hours after the last session. The mRNA expression of IL-6 were analyzed in hippocampus and frontal cortex tissues by Real time – PCR. In order to determine the significant differences between groups two-way ANOVA test were used. Particulate air pollution resulted in significant increase in IL-6 gene expression in the hippocampus (p=0.007) and frontal cortex of the brain tissue (p=0.010), however, the training had no significant effect on the expression of this gene. Despite the lack of significant effect of training on gene expression of IL-6, the results showed that the expression of this gene in training and training-air pollution groups was lower than air pollution group. So, it seems that training can moderate the neuro-inflammatory effects of air pollution by reduction of IL-6.

This study aimed to identify the possible effects of the different types of exercise on levels of brain-derived neurotrophic factor (BDNF-Brain-Derived Neurotrophic Factor) in the hippocampus of adult rats. In this experimental-trail، Thirty-five Wistar rats were divided into five groups: (1) Sedentary (Sed)، (2) Endurance Training (ET)، (3) High-Intensity Interval Training (HIIT)، Sprint Training (ST)، Incline Treadmill Workout (ITW); Sed group was regarded as control. ET group received 8-wk Mild-intensity endurance exercise. The exercise schedule of HIIT group consisted of high intensity interval training for 8 weeks (with Active recovery). ST group ran on treadmill for 8-weeks with high intensity. ITW group ran on the inclined treadmill. Hippocampal BDNF protein was assessed using commercial ELISA kits and the data were analyzed by one-way ANOVA. Statistical differences were considered significant at α<0. 05. The results showed that all training groups had no significant differ in BDNF protein level comparison with the Sd group (PET=0. 786، PHIIT= 0. 135، PST= 0. 163، PITW=0. 172). However، altered exercise training did not differ significantly BDNF levels، it seems، higher intensity exercise and stress can affect more change in hippocampus BDNF levels.

Transcription factors (TFs) are molecules that regulate some genes including neurotrophins in multicellular organisms. Recently has been shown that these elements play significant role in crucial processes such as; differentiation and development through regulation after translation. Our goal in this study was examination of effect of light aerobic running on the expression of NRSF/REST andchanges in BDNF protein in the hippocampus of adult male rat. This experimental study was conducted with the animal model so 24 adult male wistar rats, 8 weeks of age, were selected as subjects (with mean body weight of 200-225 gr). The animals randomly divided into 2 groups of control (n=12) and runner (n=12). In runner group, animals daily were allowed to run on treadmill at a speed of 12 m/min, for 30 minutes, for 2 weeks. Changes in protein levels were determined with ELISA technique. Changes in expression of genes estimated using qRT-PCR technique.Statistical analysis using SPSS software, by independent sample T test showed that, light aerobic running leads to decreased expression of REST and an incensement in BDNF protein levels statistically (p≤0.05). How changes in these two factors show that, exercise as a mediating factor is involved in growth and neuronal survival, synaptic plasticity and on the other hand, neuronal differentiation in the hippocampus of adult male rats.