جستجوی مقالات مرتبط با کلیدواژه "vascular function" در نشریات گروه "تربیت بدنی"

Cardiovascular diseases are the most important cause of death among women. Hormonal changes around and after menopause can affect inflammatory factors such as interleukins and tumor necrosis factor alpha (TNF-α) as well as vascular function. The aim of this research was to determine the effect of a session of aerobic exercise with moderate intensity on interleukins 6 and 8, TNF-α, as well as vascular function (flow mediated dilation) in premenopausal and postmenopausal women.

In this semi-experimental study, 30 inactive women without any cardiovascular disease participated in the study voluntarily, which were allocated into two equal groups (n=15) of premenopausal women (age, 47.7±1.3 years) and postmenopausal women (age, 56.8±1.5 years). Participants in both groups performed a session of moderate intensity aerobic exercise included 30 min of running on a treadmill at 60-70% of heart rate reserve. Participants' blood samples were collected 30 min before and 30 min after the exercise and were analyzed to measure inflammatory factors (interleukin 6, interleukin 8 and TNF-α). Vascular function was evaluated by measuring flow mediated dilation at 15 min before and 15 min after aerobic exercise. Data were analyzed by using SPSS software and covariance test (P>0.05).

In response to a session of moderate intensity aerobic exercise, no significant difference was seen in interleukin 6 and 8 between two groups of premenopausal and postmenopausal women (P=0.432, P=0.097), but TNF-α decreased significantly in premenopausal whereas it it did not change in postmenopausal women (P=0.003). In addition, vascular dilation after a session of moderate intensity aerobic exercise was significantly (P=0.001) different between premenopausal and postmenopausal women , where, flow mediated dilation increased in premenopausal compared to postmenopausal women.

Based on the increased FMD and decreased TNF-α in premenopausal women, in general our findings show that following acute exercise factors associated with endothelial responsiveness are improved in premenopausal women while responses are decreased in postmenopausal womenHowever, lack of differences in interleukins 6 and 8 between premenopausal and postmenopausal women might indicate increased inflammation in premenopausal women, which is a reason for the onset or increases in disorders of endothelial function during menopause.

Recently, the technique of restricting blood flow (BFR) has become more popular among researchers, physicians, physiotherapists, and coaches due to its anabolism effects. Given the importance of adaptive response of hormones and vascular function to exercise with BFR, this study examines the effect of BFR composition and rock climbing activity on the hormonal response of growth hormone and insulin-like growth factor1 and plasma nitric oxide of elite rock climbers.

In this quasi-experimental study with pre-test and post-test design. 20 climbers (weight: 61.55±8.69, fat percentage: 15.29±8.05 and age: 26.6±2.6) as accidentally, they were divided into two training groups (5 men + 5 women each) with limited blood flow and no blood flow restriction. The training protocol was 4 weeks and 3 sessions of climbing training per week. Blood pressure was about 40 to 100 mm Hg. Blood sampling was performed at baseline at rest before and after exercise to determine growth hormone, IGF-I, and nitric oxide levels. Also, the strength of the dominant hand grips was measured before and after the training period. Data were evaluated using spss v16 statistical software and paired t-test and p <0.05.

After climbing training, only a significant increase was observed in the basal level of growth hormone and nitric oxide, but the basal level of IGF-I showed a low increase. And the strength of the dominant hand grips increased in both groups.

Apparently, climbing exercises with blood flow restriction improve anabolic processes, muscle strength, and vascular function.

Chronic inflammation is an integral part of cardiovascular disease and high blood pressure was found to be associated with endothelial dysfunction. The aim of this study was to evaluate the effect of endurance training and Galbanum supplement on parameters related to vascular function includes endothelial selectin (E-SELECTIN) and angiotensin converting enzyme inhibitor (ACE-I) as inflammatory factors and vasoconstriction and nitric oxide (NO) as a factor vasodilation during chronic hypertension induced by Nitro-L-arginine methyl ester (L-NAME) in male Wistar rats. 48 male Wistar rats were randomly divided into six groups; 1) basic، 2)sham، 3)L-NAME، 4)endurance training، 5)Galbanum and 6)training+Galbanum. Groups of 3 until 6، five times a week for eight weeks، 10 mg / kg L-NAME solutions were given. Also، rats in the sham group received saline in the same conditions. Groups of 4 and 6 were performed endurance running protocol on a treadmill speed of 15 to 20 meters per minute for 25 to 64 minutes 5 times a week for 8 weeks. Groups of 5 and 6 received 90 mg / kg dissolved Galbanum using gavage 5 times a week for 8 weeks. Infusion of L-NAME was led to hypertension، as was detected by significance decrease in ACE-I (p<0. 00). Furthermore، hypertension was associated with increased NO and decreased E-SELECTIN. The training protocol significance reduces E-SELECTIN (p<0. 00) and significance increased NO (p<0. 04) in the 4 group and administration of Galbanum causes a decrease in E-SELECTIN (p<0. 00) in the 5 group and combine training and galbanum causes a significance decrease in E-SELECTIN (p<0. 00) and a significance increase in NO (p<0. 03) in group of 6، as compared to L-NAME group in p<0. 05 significance level. Chronic hypertension is associated with endothelial dysfunction and use of non-pharmacological strategies such as endurance training and Galbanum antioxidant supplementation probably through vascular endothelial function can cause controlled high blood pressure.