جستجوی مقالات مرتبط با کلیدواژه « lipid parameters » در نشریات گروه « علوم پایه »

In this experiment, 50 male Wistar rats were randomly divided into two groups (25 series). A group of 25 was induced with diabetes. Experimental groups included: (healthy control), healthy recipient of mixed bacteria isolated from Yogurt, healthy recipient of pure lactobacilli bacteria, healthy recipient of mixed bacteria isolated from yogurt plus oleic acid, healthy recipient of pure lactobacilli bacteria plus oleic acid, diabetic control, diabetic recipient of mixed bacteria isolated from yogurt , Diabetic receiving pure lactobacilli, diabetic receiving mixed bacteria isolated from yogurt plus oleic acid, and diabetic receiving pure lactobacilli plus oleic acid. The results showed that in healthy mice, all experimental treatments significantly increased blood glucose, cholesterol and triglycerides and decreased LDL. In healthy mice, the probiotic Lactobacillus significantly reduced the blood HDL of healthy mice. In diabetic rats, supplementation of all experimental treatments significantly reduced blood glucose, cholesterol, LDL and HDL. In this group, the greatest effect of reducing blood glucose, cholesterol and LDL was related to probiotic treatment produced from yogurt plus oleic acid. In both healthy and diabetic groups, experimental treatments significantly increased serum levels of liver enzymes (ALT, AST, ALP and CK). The greatest effect of increasing the serum activity of liver enzymes in the diabetic group was related to the treatment of lactobacillus plus oleic acid.

With the increasing use of nanoparticles in pharmaceutical applications, concerns about their possible negative effects on the body have also increased. Therefore, the present study aimed to investigate the effects of different levels of gold nanoparticles on the activity of ALT and AST, ALP enzymes as well as fat profile (TG, Chol, LDL) in male rats. For this study, 30 adult male Wistar rats weighing 200±50 g were divided into 3 groups of ten. The control group, salin and the other two groups were received gold nanoparticles at 100 and 1000 mg / kg body weight by gavage for 3 weeks. The results showed that the level of 100 mg of gold nanoparticles compared to other groups significantly reduced the serum levels of all three liver enzymes ALT, AST and ALP. Meanwhile, the 1000 mg group of gold nanoparticles compared to the other two groups, caused a significant increase in the level of ALT, AST and ALP (p<0.05). In addition, while the 100 mg group of gold nanoparticles had no significant effect on serum lipid parameters, the 1000 mg group caused a significant increase in all three lipid indices of cholesterol, triglyceride and blood LDL (p<0.05). In general, the results of this study showed that the level of 100 mg of gold nanoparticles reduced the serum level of liver enzymes and this level can be successfully used in pharmaceutical applications.