جستجوی مقالات مرتبط با کلیدواژه « آترواسکلروزیس » در نشریات گروه « پزشکی »

Atherosclerosis is an inflammatory disease and is one of the leading causes of cardiovascular disease. Vascular plaques are formed on the inner surface of hardened arteries and gradually develop, reducing the diameter of the arteries. CXCR4 is one of the most important chemokine receptors, whose presence has been confirmed in cardiac plaques. Our aim was to determine the relationship between genetic diversity of CXCR4 gene (rs2228014) and atherosclerosis among the population of patients.

The present study included 254 participants who referred to the Cardiac Angiography Department of Afshar Hospital in Yazd City. The main criteria for admission to the case group were coronary artery stenosis with angiography testing, and in the control group, the clients did not have coronary artery disease. The age and sex matching of the two groups were considered. Blood specimens were taken, and after DNA extraction, the SNP genotype of the CXCR4 gene was determined using ARMS-PCR. Statistical analysis of the data carried out using SPSS software version 19 and Chi-square test.

Genetic models of rs2228014 variant were evaluated in patients with atherosclerosis in comparison with the control group and a significant difference between allelic (P = 0.333), homozygous (P = 0.087), heterozygous (P = 849.0), dominant (P = 0.570) and recessive (P = 0.086) genetic models of rs2228014 polymorphism was not observed.

In the current study, no significant difference was observed between genetic models of rs222801 polymorphism in patients with atherosclerosis and healthy individuals. Based on our findings, the rs222801 polymorphism of the CXCR4 gene might not be considered as a predisposing factor for atherosclerosis.

The main problem with using stents in the treatment of coronary artery atherosclerotic stenosis in percutaneous coronary intervention (PCI) is In-stent restenosis (ISR). In this study, we investigated the possible role of the G22A variant of the Adenosine Deaminase gene (ADA) in the development of ISR. In this study, 91 patients who underwent PCI were divided into two groups: the case with ISR (n=40) and control without ISR after 6 months from stenting (n=51). The case and control groups were matched in terms of age and sex matching. The genotypes of the G22A variant in the samples were examined by the molecular method of PCR-RFLP and electrophoresis and the results were statistically analyzed by using t-test. The results of this study show that the frequency of allele A of variant G22A in (+ ISR) group is higher than (- ISR). However, there is no significant relationship between the distribution of allele and genotype frequency of this variant with the incidence of ISR (p>0.05).

We aimed to examine the atherosclerotic patterns of lower limb arteries in patients with diabetes mellitus undergoing angiography in Razi hospital, Rasht, Iran, in 2016.

In this retrospective cross-sectional study, patients with diabetes mellitus underwent angiography in an endovascular surgery center in Razi Hospital in Rasht in 2016, were evaluated. Demographic characteristics, disease-related factors, and angiographic findings were recorded. Proximal Pattern in this study was defined as significant involvement of suprageniculate arteries, and the distal pattern was defined as significant involvement of infrageniculate arteries. The extent of vascular involvement in this study was measured by trans-atlantic inter-society consensus 2 (TASC2) scale.

169 patients were included in this study. 60.9% of the patients were men, and the average age was 64.34 ± 10.26 years. Chief complaint in 58% of the patients was non-healing ulcer (58.0%). 47.3% of the patients had dyslipidemia, 65.1% had hypertension, and 22.5% of them had no other underlying diseases. 24.3% of the patients were smokers. In general, in 62.7% of all patients, the pattern of atherosclerotic involvement was distal. There was no significant relation between atherosclerotic involvement pattern and sex, body mass index (BMI) range, history of renal disease, or dyslipidemia.

The findings showed that the most prevalent pattern of atherosclerotic vascular involvement in patients with diabetes mellitus was distal pattern. There was no significant relationship between atherosclerotic pattern and sex, BMI, history of renal disease, and dyslipidemia.

Diabetes mellitus, which is associated with elevated blood glucose, lipids and liver enzymes, may results in alterations in the production of inflammatory cytokines, including chitinase-3-like protein 1 (YKL-40) and high-sensitivity C-reactive protein (hs-CRP), which induce and promote complications of diabetes such as atherosclerosis.The aim of this study was to evaluate the serum level of chitinase-3 like 1 protein (YKL-40) and high-sensitive C-reactive protein (hs-CRP) in type 2 diabetes with coronary artery disease compared to diabetic and healthy control.

This cross-sectional study was performed on 87 subjects in four groups, including: 23 samples as healthy control (Group 1), 22 patients with type 2 diabetes (Group 2), 20 patients with coronary artery disease (Group 3) and 22 patients with type 2 diabetes and coronary artery disease (Group 4). Serum Fasting blood sugar (FBS), Cholesterol, Triglyceride, Low density lipoprotein (LDL-C), High density lipoprotein (HDL-C), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), YKL-40 and hs-CRP were determined.

The mean serum levels of FBS (Group 1 with 2 and 4, Group 2 and 3, P = 0.001), Cholesterol (Group 1 and 3, P = 0.03), Triglyceride (Group 2 and 3,p=0.027), HDL-C (Group 1 with 3 and 4, P = 0.02, P = 0.01 respectively), ALT (Group 1 and 4, P = 0.03, Group 2 and 4, P = 0.02) and AST (Group 2 and 4, P = 0.009) were significantly different..The mean serum levels of YKL-40 were significantly difference in the group 1(4.81±1.27 ng/ml) and group 2 (15.52±4.61 ng/ml) (P=0.01), group 3 (19.2±2.75 ng/ml, P=0.017) and group 4 (16.1±4.17 ng/ml, P=0.04). Also, The mean serum levels of hs-CRP in the group 3 (4.49± 1.53 μg/ml) and group 4 (1.28 ± 0.43 μg/ml) was significantly difference (P= 0.028).

Serum levels of YKL-40 are increased in people with type 2 diabetes and coronary artery disease. It is recommended to determine the serum level of this marker in these patients.

One of the most important of heart problems is related to the occurrence of atherosclerotic plaques. One of the underlying factors in this regard is bacterial infections. Many studies indicate the association between Chlamydia pneumoniae and the creation of plaques; it is one of the most important organisms in the development of coronary heart disease. The aim of this study was to investigate the association between the antibodies against Chlamydia pneumoniae and those relation with coronary atherosclerosis.

In this descriptive case-control study, serum samples were collected from two groups of patients (108 patients) and healthy subjects (108 persons). Anti-Chlamydia pneumonia antibody titers were evaluated; patients under study were diagnosed with acute myocardial infarction. Both groups were matched in terms of the age and sex to reduce possible interactions.

In the evaluation of IgG antibody titers by ELISA and comparison between the two groups, the positive titers were 88.2% in the case group and 60.5% in the healthy subjects; this percentage was 74.6% in all subjects. The results of the two groups were statistically significant (P ≤ 0.005).

Regarding the significance of the results in comparison between the patient and the control group, it can be argued that the presence of Chlamydia pneumonia can have a significant relationship with the development of atherosclerotic plaques. Despite the controversial findings in this regard, precise molecular studies can reveal possible mechanisms for the association of bacterial infections and the development of atherosclerosis.

The relationship between iron status and risk of atherosclerosis in beta- thalassemia patients has been shown previously. The aim of this case-control study is to compare common carotid artery intima-media thickness (CIMT) in beta-thalassemia major, intermedia, and minor with healthy individuals.

In this, case-control study, 27 beta-thalassemia major patients, 27 beta-thalassemia intermedia, and 27 beta-thalassemia minor (age: 18-29 years) with similar sex ratio were investigated in Jahrom, Fars province, Southern Iran. In addition, 27 sex-matched healthy controls with the same age range were randomly selected from individuals referred to the out-patient clinic. Exclusion criteria were diabetes, hypertension, obesity, thyroid dysfunction and smoking.

Serum low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were significantly lower in patients with beta-thalassemia major and intermedia in comparison with beta-thalassemia minor and healthy control (P<0.001). In all thalassemia groups CIMT were significantly higher in comparison with healthy individuals (P<0.001). These results were similar after removal of confounding effect of other variables including serum ferritin levels, cholesterol, LDL, HDL, and age.

It seems regardless of other relative risk factors of atherosclerosis, being beta-thalassemia is an influential determinant on the occurrence of atherosclerosis. Maybe some molecular and genetic factors can influence the occurrence of atherosclerosis in these patients that needs further larger combined clinical and basic studies.

Paraoxonase-1 is a calcium dependent enzyme which is related to HDL. Paraoxonase LDL plays an important role in prevention of atherosclerotic lesions by having preventing potential. Different antioxidants such as flavonoids affect serum paraoxonase activity. In the current study, the aim was to investigate the effect of some flavonoids on serum paraoxonase activity.

In this animal experimental study, 45 Wistar rats in 9 groups of 5 animals received flavonoids by gavage feeding as follows: Group 1 as control group received 1 ml water daily and ethanol with concentration 0.25. Group 2-5 and 6-9 was fed with 7.5 and 15 mg/kg for per kilogram of body weight (BW) of the one of myricetin, quercetin, kaempferol and galangin flavonoids along with 1 ml ethanol 25%. The mean of changes in enzyme activities due to performed intervention between groups was compared using one-way ANOVA.

There were significant differences between PON-1 enzyme activity changes before and after intervention in both dosages 7.5 and 15 mg/kg body weight (P=0.04). There were significant differences in increasing concentration between PON-1 enzyme activity changes before and after intervention (Gavage for 4 types of flavonoids) compared to control groups (P≤0.009), but there was not any significant difference between PON-1 enzyme activity changes used two dosages of flavonoids (P>0.05)

In this study, it was shown that all of the flavonoids increased paraoxonase activity. Probably, the potential of flavonoids in increasing serum paraoxonase activity is related to the number and location of hydroxyl groups on these compounds.