جستجوی مقالات مرتبط با کلیدواژه "استئوسارکوم" در نشریات گروه "پزشکی"

The purpose of this study was to investigate the effect of sports rehabilitation exercises with vitamin D consumption on fatigue, sleep quality and depression level of people with osteosarcoma cancer after bone marrow stem cell transplantation.

In this study, 27 women with osteosarcoma cancer with body mass index above 30 kg/m2, age 24.90±4.03 years, height 163.85±3.62 cm and weight 82.17±4.5 kg were randomly divided into four groups. (patient-exercise), (patient-exercise-vitamin D), (patient-exercise-placebo) and (control) were divided. The training protocol includes ten weeks of Pilates exercise. The supplement group took 500 IU of vitamin D three days a week for 10 weeks. Data were analyzed using dependent t-test and one-way analysis of variance.

The results of the covariance analysis of the research of three exercise groups showed that after ten weeks of sports rehabilitation with vitamin D consumption, the indicators of fatigue and the level of depression decreased significantly (P≤ 0.05). Also, the results of covariance analysis of the three training groups showed that the overall sleep quality of people with osteosarcoma cancer increased significantly (P≤ 0.05).

Based on the obtained results, it is suggested that the consumption of vitamin D along with exercise rehabilitation can be an effective treatment method for fatigue, sleep quality and depression in people with osteosarcoma cancer.

Fibro-Osseous-Lesions (FOLs) in jaws have been considered as one of the most important diagnostic challenges. FOLs are benign lesions in which part of the normal jaws bone is replaced by mineralizing fibrotic connective tissue. Different types of FOLs have some differences in etiology, treatment and prognosis but they may show similar in radiographic and microscopic view. Furthermore, they may also have microscopic similarities with some low-grade malignant lesions of the jaw. Therefore, in this review, we have tried to bring this always challenging story to a good and practical conclusion by providing specific and practical indicators for more accurate diagnosis of these lesions by examining the most important related studies.

Evaluated studies were in the range of 2011 to 2021. Our criteria for entering the study were associated researches with diagnostic challenges of FOLs and purposes of the study include: determining the connection among the clinical and pathologic FOLs, distinguishing various diagnostic challenges of FOLs from each other and malignant bone lesions.

The results of this study declare that accurate and correct diagnosis of FOLs requires a connection between clinical, radiographic and histopathological data.

 Osteosarcoma (also called osteogenic sarcoma) is the most common type of cancer that starts in the bones. It is a malignant mesenchymal cell tumour, characterized by pleomorphic spindle-shaped cells, capable of producing an osteoid matrix. Tumour cells metastasize primarily via the haematogenous route. This disease is very aggressive and the tumor formed is fixed, hard and irregular. The cancer cells in these tumors look like early forms of bone cells that normally help make new bone tissue, but the bone tissue in an osteosarcoma is not as strong as that in normal bones. Overall, osteosarcoma is a rare disease, however, children and teens are the most commonly affected age group, but osteosarcoma can develop at any age. Although this disease occurs sporadically, approximately 70% of tumor specimens show an abnormality in the chromosome. Moreover, regulation of cell cycle has been reported to demonstrate inherited defects in some cases. The incidence of osteosarcoma is bimodal. The first peak occurs at the ages of puberty, implying the ages of 15 to 19 in boys and the ages of 10 to 14 in girls. The second peak occurs in the elderly with the age of 75 years. Noteworthy, osteosarcoma is rare before the age of 5. With the application of multimodal chemotherapy, disease-free survival of patients with high-grade osteosarcoma has been improved to more than 60% compared to 10–20% which was reachable with the surgery as the only therapeutic approach. At present, treatment of osteosarcoma is a combination of surgery and chemotherapy both before and after the surgery. Additionally, the use of common chemotherapeutic agents such as high-dose methotrexate, cisplatin, doxorubicin and/or etoposide and ifosfamide frequently causes both acute and long-term toxicity. Although several chemotherapy regimens have been applied in the past 20 years, survival rates of patients are still not satisfying and no practical targeted therapy is discovered. Therefore, it is important to investigate different therapeutic methods and anti-tumor agents in order to find an approach that provides a higher survival rate. Flavonoids possess several biological and pharmacological activities. In addition, flavonoids have the advantage of being less toxic and can be prescribed for an extended duration. Therefore, various plant-derived flavonoids use as drugs have been reported as a modulator for chronic inflammation caused by virus infection and other diseases, such as human papillomavirus, hepatitis virus, SARS-CoV-2, autoimmune disease, type 2 diabetes, cardiovascular diseases, Alzheimer’s disease, Parkinson’s disease, and cancer. Quercetin is a naturally occurring polyphenolic flavonoid, whose chemical name is 3,3′,4′,5,7-Pentahydroxyflavone (C15H10O7), can be found in a wide range of daily foods, such as grains, fruits, and vegetables and in higher levels in capers, buckwheat seeds, radish, onions, apples, red leaf lettuce, asparagus, nuts, and teas. It is reported that oral administration of 1 g quercetin per day is safe and is absorbed up to 60%. Quercetin has a high ability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS) molecules; therefore, exhibiting beneficial effects in preventing obesity, diabetes, cardiovascular diseases, and inflammation. Furthermore, quercetin is indicated to exert various anti-tumor effects both in vitro and in vivo against several cancers, such as ovarian cancer, colorectal cancer, lymphoma, gastric cancer, and breast cancer. On the other hand, the high toxic effect of quercetin against cancer cells is accompanied with little or no side effects or harm to normal cells. Its wide accessibility, efficacy, and a broad range of activity, and low toxicity as compared with other examined compounds, make it an attractive chemical in the fight against diseases including cancer. It has been recognized and employed as an alternative drug in treating different cancers alone or in combination with other chemotherapeutic drugs. NO is a free radical that regulates several physiological functions and is formed by the conversion of L-arginine to L-citrulline by nitric oxide synthases (NOS). NO is a dual molecule that can have a tumor-protecting or stimulating effect, depending on its local concentration. Certain reports demonstrated a cytotoxic role of NO; others presented a protective role. Many investigations have shown that quercetin has anti-inflammatory activity that pulls out the nitric oxide, catalase, and cytokines, specifically TNF-α, IL-β, and IL-6, which are inflammatory mediators. Therefore, we tried to elucidate the influence of quercetin in order to suggest a new candidate for the treatment of this cancer, on in vitro NO production from Saos2 osteosarcoma cell line

After 24 hours of culture of Saos2 cells in 96-well plates, different concentrations of quercetin were added to the wells for 72 hours. Cell viability was measured using the colorimetric MTT assay. Briefly, cells were incubated with 0.5mg/mL MTT in DMEM at 37 ºC under 5 % CO2 for 3 h. The blue formazan reduction product, which is generated by the action of the succinate dehydrogenase on the dye only in living cells, was dissolved in 100µL DMSO, and its absorbance was read at 570nm using a Dynex MMX microplate reader. The level of nitrite as an indicator of NO production in the culture medium was measured using modified Griess reagent. In brief, after the experiment, the medium in each well was removed and centrifuged at 10,000 g for 10 min at 20 ºC. Then, 100 µL of the supernatant was mixed with an equal volume of Griess reagent at room temperature for 10 min, and the absorbance was measured at 540 nm using a microplate reader. The nitrite concentration was determined from a sodium nitrite standard curve.
The data were analyzed by one-way ANOVA and P < 0.05 was considered statistically significant.

The results of this study showed that quercetin can decrease the percentage of cell viability of Saos2 cells compared to the control group. The best effective dose is 120 μM. Also, the data showed that quercetin in all concentrations was able to reduce the production of NO levels in Saos2 cells and the best effective concentration is 120 μM.

In this study, it was found that quercetin was able to reduce the viability of Saos2 cells, and part of its effects could be mediated partially by a decrease in NO production. However, further studies are needed on this natural compound.

Osteosarcoma of jaw bones is the most common primary malignant bone tumor arising from mesenchymal cells capable of producing steoid; this disorder predominantly occurs in the long bones and rarely involves the maxillofacial region. Normally, this disease presents in the third and fourth decades of life, is slightly more common in men than women, and affects the mandible and maxilla in the same proportion.
Case report: An 8-year-old girl was referred to an oral and maxillofacial surgeon due to tumoral lesions in the posterior mandible in Sari, Iran. After the surgery, histopathological examination of the tumoral lesions revealed fibroblastic osteosarcoma. Further, immunohistochemical markers were evaluated, results of which approved final diagnosis of mandible osteosarcoma.
Given that osteosarcoma of jaw bones share the same clinical manifestations with benign lesions, misdiagnosis is highly common and diagnosis is challenging for dentists. Accurate diagnosis and early referral are critical in prognosis and survival of patients.

Osteosarcoma is one of the most prevalent malignant bone tumors . This study is designed to assess the prognostic effect of pathologic fracture and treatment options on survival of patients with osteosarcoma.
In this study, prognosis of 106 patients with limb osteosarcoma, which were treated at three hospitals in Tehran from April to August 2012 was evaluated. Patients were divided in two groups according to the presence of pathologic fracture at the time of diagnosis. Survival, local recurrence and distant metastasis were compared between groups. For patients with pathologic fracture, survival rate was compared according to surgical options (amputation or limb salvage). Chi-square and Independent sample T-test were used to compare means of the groups. Recurrence free and metastasis free survivals and final survival of the patients were calculated using the Kaplan-Meier method. To determine the predictive factors of survival, Cox-Regression analysis and estimating hazard ratio (HR) with 95% confidence interval were used.
Among 106 patients, 57 cases had not and 49 others had a pathologic fracture at the time of diagnosis. There were no statistically difference between two groups in Survival (P-value=0.36), local recurrence (P-value=0.91) and distant metastasis (P-value=0.73). There was no statistically difference in survival according to surgical options in patients with pathologic fracture (P-value=0.85).
pathologic fracture in limb osteosarcoma is not a poor prognostic factor. In patients with pathologic fracture limb salvage procedures can be performed without adverse effect on survival rate.

Primary malignant tumors of the chest wall are rare and include about 5 percent of all chest wall tumors. Primary osteosarcoma of the rib has very low prevalence and mostly exists in young age. Case Report: We present a 70-year-old man with a very large tumor of the chest wall, becoming gradually larger, for about 30 years. It underwent resection and reconstruction and was reported to be well differentiated osteosarcoma in pathological study.

Background and Osteosarcoma is among primary bone tumors, seen mostly in long bones among young adults. Therapeutic approach to this disease consists of surgery and chemotherapy. Unfortunately, there is no access to information on its early symptoms and the high risk group. Therefore, in this study we have assessed the epidemiologic, clinical and paraclinical characteristics of osteosarcoma. Methods and Materials: This cross sectional descriptive study involved 100 cases of osteosarcoma with various ages admitted to academic hospitals in Mashad, Iran. The obtained data were analyzed statistically in SPSS 11.5. There were 69 male and 29 female patients, with a mean age of 17.6±7.04 years. The most common tumor sites were femur (46%) and tibia (41%). Bone pain (56 cases), swelling (18 cases) and pathologic fractures (11 cases) were the most common complaints. Osteosarcoma can be recognized as a malignancy in young male adults, which is characterized mainly with pain.

The present study aims to report osteosarcomas of the maxillofacial area between 1991 and 2000 in two important referral centers of Tehran: Cancer institute of Iran and Taleghani hospital. Method & Material: All relevant data were recorded from files of patients with a final diagnosis of osteosarcoma and registered in a descriptive manner in prepared data sheets. Among the 42 cases of maxillofacial osteosarcoma, 24 (57.1%) were male and the remaining 18 (42.9%) were female. Their average age was 34.1 years. Maxilla to mandible ratio of involvement was 1.05. Swelling was the main chief complaint (88.5%) and 96.3% of the cases could be categorized as conventional. Most of them (75%) were chondroblastic histologically. A total of 212 cases of osteosarcoma other than in jaws had been registered during the same period. They were 18.81 years old on average and comprised 144 males (68.2%) and 67 females (31.8%). Histologically, they were chiefly chondroblastic (35.3%). In general, jaw involvement constituted 16% of the whole body involvement. The mean age was significantly higher in tumors of the jaws and they also showed a significantly higher percentage of involvement by the chondroblastic subtype.

Bone tumors are uncommon and have two groups, primary and secondary tumors. The later consists of metastatic tumors and it is more common than the primary tumors. Bone tumors are rare in body. This study is designed to determine the frequency of bone tumors in Kurdistan. This study was descriptive and documented data were collected from governmental and private centers from 1996 to 2000 in Kurdistan. There were 190 files and necessary data consist of histopathologic types of masses, age, sex and location of lesions were analyzed with descriptive analysis. From 190 primary bone tumors 8.4% were malignant, 69.5% were benign and 22.1% were tumor like lesions. Osteochondroma was the most frequent in benign tumors (57.6%) and its frequency among all of the bone tumors was 40%. In malignant tumors osteosarcoma and giant cell tumor have the most frequency (25%). Among all pathologic types consist of malignant, benign and tumor like lesions, the frequency for male was more than female. Most of bone masses that were been biopsy are benign and malignant tumors are rare.