جستجوی مقالات مرتبط با کلیدواژه « رمینرالیزاسیون » در نشریات گروه « پزشکی »

The aim of this study is to examine the impact of incorporating Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP), produced at the Dental Materials Research Center of Mashhad University of Medical Sciences, into an Iranian toothpaste on the remineralization of enamel lesions.

Twenty enamel blocks were obtained by cutting sections from the crowns of cow incisor teeth. Each enamel block was divided into thirds; one-third was varnished to serve as the healthy control, while the remaining two-thirds underwent a demineralization process.Following demineralization, the remaining half of the enamel block surface was varnished, leaving only the third area exposed to the remineralization process. The 20 enamel blocks were then divided into two groups: the first group received Meridant Complete7 toothpaste, and the second group received Meridant Complete7 toothpaste containing 1% CPP-ACP by weight.In each group, the designated toothpaste was applied to the exposed third area for 3 minutes, followed by washing with distilled water and placement in an artificial saliva solution. This procedure was repeated daily for seven days. Remineralization was assessed using the Vickers microhardness method, measuring at depths of 20, 50, 100, and 150 micrometers in the three designated areas, from the surface to the depth.

The results indicated that the incorporation of CPP-ACP into Merident toothpaste significantly enhanced remineralization at depths of 20 micrometers (p=0.028) and 50 micrometers (p=0.033). However, at other depths, the addition of CPP-ACP did not yield a statistically significant difference in the toothpaste's impact on remineralization.

In conclusion, the findings of this study demonstrate that the incorporation of CPP-ACP into Merident Iranian toothpaste enhances its efficacy in remineralizing enamel lesions, particularly in the surface layer of tooth enamel

Various factors contribute to tooth decay. Modern dentistry suggests different ways to enhance remineralization and prevent caries progression. The present study aimed to evaluate the effect of nano-hydroxyapatite toothpaste and mouthwash on the remineralization of primary enamel lesions and occlusion of dentinal Tubules.

A total of 45 extracted human central teeth were used in this study. Artificial decay was induced by placing samples in a demineralization solution in an incubator at 37°C for 72 h. The hardness of four samples of demineralized teeth was determined by a microhardness test. The samples were divided into three equal groups according to the table of random numbers. The samples were subjected to pH cycling for 14 days, which included 3 and 21 h of demineralization and remineralization, respectively. SEM and Vickers microhardness tests were performed and the results were compared and the degree of occlusion of dentinal tubules was reported. Then the results were analyzed using SPSS software (version 24) and descriptive statistics, ANOVA, and Tukey's multiple comparison test.

The results of repeated measures ANOVA indicated a statistically significant difference in microhardness changes between the studied groups (P=0.006). Also, in-group analysis of microhardness changes in the groups demonstrated a significant difference between these changes (P<0.0001).

According to the obtained results, using nanohydroxyapatite can considered as a therapeutic approach to repair decayed teeth and it increases dental microhardness when added to varnish.

For decades, using fluoride has been introduced to prevent the development and progression of primary carious lesions. Increased surface microhardness of primary caries is among the essential factors in preventing lesion progression and cavity formation. The present study aimed to compare the microhardness changes of primary caries treated with 3 products, containing fluoride (varnish, toothpaste, & mouthwash) in dental teeth.

In this study, 45 extracted human deciduous molars were used. Using a diamond-winning disc, enamel blocks with a dimension of 1 x 4 x 4 mm were prepared from the buccal surface of the teeth, i.e., healthy and without structural defects; they were mounted in acrylic self-adhesive. Initial microhardness test (Vicker’s test) with a force of 300 gr and Dwell time for 15 seconds was applied on samples. Next, artificial caries with the standard solution were created in all samples and the microhardness of samples was recorded at this stage. The study samples were randomly divided into 3 groups of 15, treated with fluoride varnish, mouthwash, and toothpaste. Then, the microhardness of samples was re-measured. The mean surface microhardness was compared between the study groups by Independent Samples t-test and Bonferroni test. All analyses were performed using SPSS at the significance level of P<0.05.
Ethical Considerations: This study was approved by the Ethics Committee of the Arak University of Medical Science (Code: IR.ARAKMU.REC.1397.264).

 Increase in surface microhardness of primary caries in fluoride varnish group was statistically significant; in GC MI paste plus toothpaste and Oral B mouthwash was non-significant. The research samples treated by fluoride varnish had a higher surface microhardness, compared to toothpaste and mouthwash.

According to the present research results, fluoride varnish was superior to fluoride mouthwash and toothpaste in improving the microhardness of primary dental caries.

The present study was conducted with the aim of evaluating the effects of Er:YAG laser (λ=2940 nm) and acidulated phosphate fluoride (APF) gel on the acid resistance of enamel white spot lesions, when applied alone or combined together.
This laboratory study was conducted on 90buccal and lingual slabs of human molar teeth. The samples were submitted to pH-cycling model to create white spot lesions. Subsequently, they were randomly assigned into six groups of positive control (without enamel white spot lesion), negative control (with enamel white spot lesion), enamel treated with APF gel, enamel irradiated with Er:YAG laser, pre-treated with APF gel followed by Er:YAG laser irradiation, and pre-irradiated with Er:YAG followed by APF gel application. Before and after the treatments, the samples were analyzed using potentiometer in order to evaluate the fluoride contents. Statistical analysis was performed using Kruskal-Wallis and ANOVA tests (P=0.05).
According to the results, the application of APF gel before or after laser irradiation resulted in the highest enamel resistance to acid and fluoride uptake (P As the findings indicated,Er:YAG laser changes the chemical combination of the enamel, and improves enamel hardness, especially when combined with topical fluoride, suggesting its anticaries potential

Surface micro-hardness measurements are a suitable technique for investigating the effect of these materials on the amount of enamel remanization.The aim of this study was to compare the effect of sodium fluoride mouthrinse, nano hydroxyapatite solution, resin infiltration Icon and combination of nanohydroxy apatite solution and sodium fluoride mouthrinse on the micro-hardness of demineralized enamel lesions.
In this in vitro study 50 specimens of intact human premolar enamel were chosen and randomly divided to 5 groups of 10. After the initial measurement of micro-hardness, the specimens were immersed in demineralizing solution and then the measurement were recorded again. G1 group was immersed in sodium fluoride mouthrinse, G2 group was immersed in nano hydroxyapatite solution, G3 group was treated with resin infiltration Icon according to manufacturer’s instruction and G4 group was immersed in combination of nanohydroxy apatite solution and sodium fluoride mouthrinse. The G5 group was kept in distilled water as control. After the treatments of all specimens the micro-hardness for each one were measured again. For the statistical comparison between the groups, ANOVA and LSD tests were performed.
In all groups, surface micro hardness after dimerization was significantly lower than that of enamel (P= 0.01) and in groups G1, G2, G3 and G4 after treatment the microhardness increased significantly after demineralization (P = 0.005) and in groups G1, G2, G4 and G5, microhardness decreased significantly before demineralization (P Sodium fluoride mouthwash and nano-hydroxyapatite solution both increase the surface microhardness of primary carious lesions. Infiltration resin showed the best result in increasing the surface microcrystallinity of primary carious lesions compared to other products.

Although dental caries are very prevalent, there is little information on the remineralizing capability of highly concentrated fluoride products. The aim of this study was to evaluate the effect of 1.23% Acidulated Phosphate Fluoride (APF) gel and 5% NaF varnish on remineralization of artificial enamel caries in a PH-cycling model.
In this experimental in vitro study, artificial enamel caries lesion were produced in sixty premolar teeth. Depth of caries lesions were measured using polarized light microscopy (PLM). Then sections were assigned to four groups: 1.23% APF gel (Sultan), 1.23% APF gel (Kimia) and 5% NaF varnish (Durashield) and control. After samples preparation, dental sections were placed in a 21 days PH-cycling model (6 hours at PH=4.3 and 17 hours at PH=7). The longitudinal sections were evaluated by PLM for lesion depths. The amount and percentage of depth variation for each group were calculated and data were analyzed using one-way ANOVA and Tukey test.
1.23% APF gel (Sultan) group showed greatest amount of depth reduction with the average of 25.5%. The Case groups had significantly greater reduction in lesion depth as compared with control group (P APF gel and fluoride varnish efficacy in reducing enamel caries lesions of permanent teeth were similar in this laboratory study.

Currently, a substance called casein phosphopeptide-amorphous calcium phosphate has been used as a substitute for fluoride mouthwash. This study aimed to compare the remineralization rate of fluoridated GC tooth mousse with concomitant use of fluoride mouthwash and GC tooth mousse on demineralized enamel lesions.
In this laboratory study, 50 samples were selected from 30 intact human premolars, halved into buccal and lingual segments, and randomly divided into five groups. Enamel health was recorded using a DIAGNOdent device and Vickers microhardness test.
Afterwards, the remineralized agents were applied to the surface of samples for two weeks as follows: 1) Control, 2) Fluoridated GC tooth mousse, 3) GC tooth mousse, 4) Sodium fluoride mouthwash and 5) Sodium fluoride mouthwash GC tooth mousse. Repeatedly, enamel remineralization values were recorded via DIAGNOdent device, and data were analyzed using one-way and two-way repeated measures ANOVA tests.
Our findings indicated that no significant difference was observed between remineralization rate of fluoridated GC tooth mousse and concomitant use of fluoride mouthwash and GC tooth mousse, evaluated by DIAGNOdent device (P=0.959) and Vickers microhardness test (P=0.884).
According to the results, application of fluoridated GC tooth mousse with concomitant use of fluoride mouthwash and GC tooth mousse had a similar impact on remineralization of demineralized enamel lesions.

NovaMin is a synthetic mineral composed of calcium, sodium, phosphorous and silica releases deposites of crystalline hydroxyl-carbonate apatite similar to tooth mineral composition. Furthermore, hydroxyapatite is a well known material for the remineralization of tooth enamel surface. The present study compared the efficacy of NovaMin and Nano-hydroxyapatite in the remineralization of carious lesions in permanent teeth. In an experimental in vitro trial, 30 impacted third molars teeth without any crack were selected and artificial carious lesions were developed on the teeth after exposing to demineralization / remineralizion cycles. The teeth were randomly treated with a NovaMin-contained dentifrice or nano-hydroxyapatite 2 minutes daily for a total 5 days and their Vicker’s microhardness values were calculated. The data were subjected to Student T and Mann-whitney U tests. The SMH was found to be higher in the teeth treated with NovaMin toothpaste (412.87kgf/mm2) than that in the teeth treated with NHA (388.40 kgf/mm2); however, this difference was not statistically significant. Both NovaMin-contained dentifrice and Nanohydroxyapatite solutions were effective to increase remineralization of carious-like lesions in permanent teeth.

Dental caries is one of the most common infectious diseases which could be prevented in various ways. The aim of the present study was to evaluate the effect of a toothpaste containing different concentrations of nano-hydroxyapatite on the remineralization of incipient caries. 9 sound first premolar teeth of maxilla and mandible were sectioned to four pieces. 6 specimens were stored in distilled water as control group. The remaining 30 specimens were demineralized for 72 hours and then their microhardness was measured. 0, 0.5, 1, 2 and 5% wt nano-hydroxyapatite were added to the solution of distilled water and toothpaste. Specimens were divided into 5 groups (N=6) and after demineralization, each group were randomly immersed in the above-mentioned solutions for 15 minutes. Next, specimens were kept in artificial saliva for 1 hour followed by immersion in the related remineralizing solution for another 15 minutes. This procedure was repeated for 5 days. Finally, the microhardness of the teeth was measured. Data were analyzed using repeated measures analysis of variance (ANOVA). The microhardness of demineralized teeth was increased following exposure to different concentrations of nano-hydroxyapatite, but this increase was not statistically significant (P=0.62). Nano-hydroxy apatite can enhance remineralization and increase the tooth microhardness although this increase was not significant.

The main cause of erosion is acid exposure. Side effects of erosion necessitate therapeutic agents’ uses. The aim of this study was to investigate the effects of nano- hydroxy apatite in tooth remineralization following exposure to soft beer. This in vitro experimental study was conducted on 18 human impacted third molars that had been surgically extracted. The microhardness of specimens was measured. Then teeth were exposed to soft beer and their secondary microhardness was measured. The teeth were divided into 2 groups (water and nano-hydroxy apatite solution) and were placed on 9 orthodontics appliances and delivered to 9 volunteers. These volunteers placed the tooth on one side in water for 5 minutes and the tooth in opposite side in nano-hydroxyapatite solution. This application was repeated 6 times a day for 10 days. The microhardness of teeth was measured again. Data were analyzed using Paired T-test. The tooth enamel microhardness reduced after exposure to soft beer significantly (P=0. 04). The microhardness of 9 teeth after being in water showed significant changes (P=0. 012). The microhardness of 9 teeth significantly changed after exposure to nano -hydroxyapatite solution (P=0. 001). Based on the results of this study، 10% solution of nano- hydroxy appatite could restore the erosive lesions.

The main reason for failure in application of fissure sealant is its loss of bond to tooth and development of secondary decays. Nanoparticles of hydroxyapatite have convenient biologic properties and we can try to benefit from these characteristics by adding them to repair materials. The present study was performed with the aim to assess the effect of addition of various amount nanoparticles of hydroxyapatite on mechanical properties such as microshear bond strength and physical properties like curing depth and degree of conversion as well as evaluation of teeth enamel remineralization.

In the present laboratory experimental studydifferent weight percentages comprising 0% (control)، 1%، 3%، 5%، 10% and 15% of nanoparticles of hydroxyapatite with 50 nm dimensions were separately added to fissure sealant. Then degree ofconversiontest by Fourier Transform Infrared Spectroscopy (FTIR) and curing depth according to ISO 4049 standard were performed on prepared samples. For the microshearbond strength test 35 premolar teeth without caries were used. The substance properties measurement device (Zwick) was used to do the test. Remineralization of permanent teeth enamel was assessed by Scanning Electron Microscopy (SEM). Raw data obtained were statistically analyzed by normal distribution test (Kolmogorov-Smirnov)، one way ANOVA and Tukey Post Hoc.

Results showed that microshear bond strength and degree of conversion had no significant difference in various concentrations of fissure sealant containing hydroxyapatite nanoparticles (P>0/05). Between microshear bond strength and degree of conversion means of 3M commercial fissure sealant and usual fissure sealant there was no significant difference (P>0/05). Curing depth in concentrations of 10% (P=0) and 15% (P=0) statistically significantly decreased compared to previous groups (P<0/05). Curing depth of 3M commercial fissure sealant group was lower compared to conventional fissure sealant group (P=0) and the difference was statistically significant (P<0/05). A remineralized region on the surface between the fissure sealant and tooth enamel was observed by SEM. This region was more remarkable in higher concentrations.

Fissure sealant containing hydroxyapatite nanoparticles with effect on remineralization on the surface of tooth enamel can lead to reduction of micro-leakages and prevention of development of secondary caries while mechanical properties do not decline.