جستجوی مقالات مرتبط با کلیدواژه « لقاح خارج رحمی » در نشریات گروه « پزشکی »

Although currently assisted reproductive methods are widely used in the treatment of human infertility, there are still contradictory results of studies on the growth of children after treatment with these methods, including IVF. Therefore, the present study was performed with aim to determine the growth parameters (weight, height and head circumference) in neonates born by IVF in Motazedi and Jahad University Infertility Treatment Centers in Kermanshah city.

This analytical study was conducted on 105 term neonates born in two groups of IVF infertility treatment and normal pregnancy during 2021-2022. All stages of IVF were performed in Motazedi and Jahad University Infertility Treatment Centers in Kermanshah, and then the mothers and their neonates were followed up until after birth. The information of newborns was checked in terms of height, weight and head circumference and recorded in a checklist which was the main and exclusive tool for collecting the study information. Data analysis was done using SPSS statistical software (version 20) and chi-square and Mann-Whitney U tests. P<0.05 was considered statistically significant.

The results of the study showed that the mean weight of the newborns (p=0.007) and the mean height of the newborns (p=0.021) in the normal pregnancy group were significantly higher than the IVF infertility treatment group. However, no significant statistical difference was observed in terms of head circumference (p=0.345).

The height and weight of neonates born by IVF were lower than those born with normal pregnancy, but no significant difference was observed in terms of head circumference.

Infertility is a stressful phenomenon for infertile couples, which is related to their perception of infertility. This study was designed to investigate the effectiveness of stress management training on perceived stress and the outcome of IVF in women with infertility.

A clinical trial study was conducted on infertile women referred to the Shiraz Infertility Center under IVF. 70 infertile women were selected and those eligible to enter the study were randomly divided into two experimental and control groups. The experimental group received an 8-session cognitive-behavioral stress management training program, while the control group did not receive any psychotherapy services. Both groups completed the perceived infertility stress questionnaire before and after the intervention. IVF after one month of investigation and data was analyzed using SPSS software and multivariate and univariate covariance test.

The findings showed that there was a significant difference between the experimental and control groups in terms of reducing perceived stress (F = 1031.68, p = 0.0005). But there is no significant difference in the result of IVF.

It seems that stress management training using cognitive-behavioral strategies can significantly improve the perceived stress of infertile women. This study suggests that stress management training should be included in the treatment program of infertile women.

Poor and low fertility in IVF cycles can be due to hormonal status and hormonal levels results from induced ovulation protocols. In cases of decreased ovarian reserve، follicular response to gonadotropin stimulation also decreases and the small number of oocytes will be resulted. This article measured the predictive effects of anti-mullerian hormone (AMH) and follicle-stimulating hormone (FSH) levels and antral follicle count (AFC) in infertile women prior to IVF and ICSI on ovarian response and the success rate of pregnancy.

This prospective observational study was conducted during 2011 to 2013 on 60 patients referred to Montaserie infertility center of Mashhad، Iran for IVF or ICSI. Serum levels of AMH، FSH، CBC، LFT، TFT، Ur، Cr and Prolactin were measured and vaginal ultrasound was performed to determine AFC. Required number of gonadotropin ampoules were determined and recorded. At days 20 and 21 of menstrual cycle patients underwent imitated transfer and GnRH was injected. At the 2nd day of menstruation، gonadotropin was injected. 6 days after injection، the ultrasound was performed every other day until at least two follicles up to 17-18mm were observed. Based on the number of follicles، 5000 to 10000 units of hCG was administered. After 36 to 40 hours، IVF or ICSI was performed. Finally bHCG was measured as an index of pregnancy. Data were analyzed by SPSS software version 11andt-test and chi-square tests. P value less than 0. 05 was considered significant.

The mean number of antral follicular and oocytes before and after treatment was 4. 43±4. 17 and 3. 09±3. 71، respectively. Mean of bHCG after treatment was 94. 79±265±86 Pmol/dl. Adequate ovarian response occurred in 52 cases (86. 7%) and the incidence of pregnancy was 30% (18 cases). In all patients، AMH was 1. 34±2. 66 Pmol/dl and FSH was 6. 81±4. 54 Pmol/dl. Comparison of hormone levels in women with positive and negative ovarian response showed no significant differences (p>0. 05)، but the differences of these hormones were significant in terms of pregnancy and pregnancy outcomes (p<0. 05). In pre-treatment، the level of AFC in these groups showed no significant difference (p>0. 05)، .

AMH and FSH hormones are predictive factor for positive pregnancy in infertile women after IVF and ICSI.

Controlled ovarian hyperstimulation (COH) is an important factor in IVF/ICSI success rates. CRP is a serological marker for systemic inflammation and it increases following hormonal stimulation. Probable inflammation following ovulation induction and ovarian puncture, in regards to CRP changes, might affect the outcomes of IVF programs. The present study was conducted to determine the effects of ovulation induction and puncture of ovaries on serum CRP levels in IVF/ICSI candidates.

This observational, descriptive-analytical study was performed at Avicenna Infertility Clinic during 2006 – 2007. COH was performed on 70 infertile patients who were candidates for IVF/ICSI, using standard long GnRH agonist protocol. Peripheral blood was drawn four times during the treatment cycle on the first day of stimulation and the days of HCG injection, ovary puncture, and embryo transfer. Non-serosanguinous follicular fluid samples were taken at the time of ovum pick up from each individual too. CRP levels were measured in follicular fluid and serum using competitive ELISA methods.

Serum CRP levels increased along with the stimulation cycle, from the first day of the procedure to the day of HCG injection but significant increases were seen in 82.2% of the cases following ovary puncture (respectively, 3.97±1.00g/ml, 5.54±2.26g/ml and 6.61±4.16g/ml; p<0.001). There were no significant correlations between serum estradiol and CRP levels.

Controlled ovarian hyperstimulation and ovarian puncture potentiate systemic inflammation. Serum CRP levels increase during ovulation induction cycle and also after HCG injection, but not in all patients undergoing ovarian puncture. These inflammatory reactions may affect IVF/ICSI outcomes.

Development of Assisted Reproductive Technologies (ART) and the successful birth of the first child in 1978, new therapeutic options have become available for infertile couples. Development of IVF methods made conception and embryo formation possible for the infertile, something impossible by then. ART has also brought about the possibility of third party involvement in the process of reproduction. This may occur by providing an egg, a sperm, an embryo or a uterus by a third party.

To use a donated gamete requires an evaluation and screening of the health of both donors and recipients in order to make any necessary adjustment regarding physical characteristics and specifications, blood group, social and cultural traits and religious requirements. All these ought to be in accordance with relevant rules and regulations. As ART methods enables women over 40 to conceive and bear child, meticulous evaluations of physical health, pregnancy risk factors and in particular emotional readiness of the couples is necessary. The very first step in the treatment of infertility using a substitute gamete is to inform the couple of the method of gamete and embryo supplement and the way the embryo will form in vitro. This may lessen their worries, make the procedure safer, reduce possible ethnic hazards, increase the success rate and finally bring the expenses involved to an efficient level. Other aspects that should be considered, since they may give the couple a sense of confidence are a religious and legal counseling, technique explanation, confidentiality of identities of recipients and donors None of the said aspects should be overlooked. Health evaluation could be undertaken by a history review, physical examination, infection tests, genetics and general medicine consultation.

Phonotypical characteristics of the recipient such as height, weight, skin color; hair color will be matched with donor according upon recipient’s request. Although, in most cases, matching blood group is not medically compulsory but it might be required in some cases. In many cases, recipients are interested in raising questions regarding particularities of the donor like their beliefs, social and cultural status, intelligence quota education on which a donation clinic should be cooperate.

Along with the emerged IVF technology in 1978, the possibility of fertilizing couples, who could produce gametes but were for one reason or another deprived of having children, was materialized. Assessment of applying ART methods in Iran, in particular from jurisprudential point of view, is among the main prerequisites to make such a therapeutic approach to this technology. Concepts like assisted reproductive techniques, IVF, direct transfer of donated gamete into the uterus and its comparison with formation of embryo from donated gamete after its culture, in the laboratory and the consequent embryo transfer to the uterine cavity are among the fundamental and initial concepts for familiarization of religious schools and jurisprudents with the application of donated gametes in treatment of infertile couples, which together have provided a new view point in Shiite jurisprudence in confronting treatment of infertility. The donors' and the recipients' physical and mental health are among the most important factors in assessing the process of donation which will not only increase the level of confidence in preventing transmission of genetic and non genetic diseases to the embryo but also insures a high level of compatibility in blood born, physical, cultural, social and even religious characteristics. Preparing the socio-cultural basement for application of these techniques for treatment of infertile couples calls for a comprehensive introduction of such issues in the society and also in the scientific community. For an infertile couple to volunteer to use these techniques, they need to be well aware of their different dimensions.

Any information that can affect the decision of the couple in applying these techniques must be discussed with them in comprehensive and even repeated consultation sessions and only after well educated and informed consent of the couple, application of these techniques may be allowed. It is the task of the infertility clinics to cover these issues with maximum caution.