جستجوی مقالات مرتبط با کلیدواژه "محدودیت رشد درون رحمی" در نشریات گروه "پزشکی"

Uteroplacental insufficiency (UPI) by inducing oxidative stress in the fetal brain leads to disruption of its development. The present study evaluated the effects of Naringin on the antioxidant defense system in the fetal forebrain and prevention of the hippocampal damage following UPI.

20 pregnant Wistar rats were randomly divided into 4 groups: control, UPI+Saline, UPI+Nar50 (UPI+naringin with a dose of 50 mg/kg) and UPI+Nar100 (UPI+ naringin with a dose of 100 mg/kg). In order to induce UPI, permanent occlusion of the anterior uterine vessels was performed on the embryonic day (ED) 18. Naringin and saline were gavagd from ED12-18. On the ED21, measuring the level of catalase (CAT), superoxide dismutase (SOD) and antioxidant capacity (TAC) by ELISA technique and malondialdehyde (MDA) by thiobarbituric acid method in the fetal forebrain and evaluating neuronal density in the CA1 and CA3 areas of the hippocampus were done.

A significant decrease in the brain activity of CAT, SOD, TAC and neuronal density in the CA1/CA3 areas of the hippocampus along with a significant increase in MDA was seen in the UPI+Saline group compared to the control group (p<0.05). While, a significant increase in CAT, SOD, TAC and CA1/CA3 neuronal density and a significant decrease in MDA was seen in the groups receiving Naringin compared to the UPI+Saline group (p<0.05).

Administering Naringin before induction of UPI by strengthening the antioxidant system in the fetal forebrain caused the prevention of neurological complications caused by UPI in the fetal brain.

Utreoplacental Insufficiency (UPI) causes impaired fetal brain development and induces oxidative stress, which ultimately leads to intrauterine growth restriction. Due to the antioxidant properties of Hesperidin (HES), the study aimed to outcome this compound on cognitive impairment and serum level of catalase, antioxidant capacity of total and malondialdehyde following uterine-placental insufficiency in rats.

Thirty pregnant Wistar rats were randomly divided into 5 groups: control group, UPI+NS (Utreoplacental insufficiency+normal saline), UPI+HES25 (Utreoplacental insufficiency+Hesperidin 25 mg/kg), and UPI+HES50 (Utreoplacental insufficiency+Hesperidin 50mg/kg), UPI+HES100 (Utreoplacental insufficiency+ Hesperidin 100mg/kg). UPI was induced by obstruction of the anterior uterine arteries on day 18 of gestation. Hesperidin or normal saline gavage was performed from day 12 to 18 of gestation. Evaluation of working memory, avoidant learning and anxiety-like behaviors and then evaluation of serum levels of catalase, total antioxidant capacity and malondialdehyde content were performed in one-month-old pups.

There was a significant decrease in working and avoidance memory, catalase levels, total antioxidants capacity with increased levels of anxiety and malondialdehyde in the UPI+ NS group compared to the control group (P<0.05). While in the HES-treated groups, there was a significant increase in working and avoidance memory, catalase level and total antioxidant capacity with a decrease in anxiety and malondialdehyde levels compared to the UPI+NS group (P<0.05(.

Hesperidin can improve memory and cognitive impairments in the model of uterine-placental insufficiency of rats by reducing oxidative stress damage.

Intrauterine growth restriction (IUGR) lead to abnormalities in fetal central nervous system, till hippocampal and cortical cells became apoptotic. The goal of this research is investigating the effects of Gallic acid on improvement of cognitive impairments and nuclear factor kappa B (NFƙB) in animal model of IUGR. In this experimental study, 32 female rats from wistar race with weighing approximately 180±25g were divided into 4 groups of 7 .Control group: that did not receive any treatment . IUGR group: To induce IUGR of pregnant rats were under 50 % restricted diet from the 14th day of pregnancy to childbirth. Experimental groups 1 and 2: pregnant rats subjected to a 50 % dietary restriction for induction IUGR from 14th day of pregnancy to childbirth and from 12th day of pregnancy to the birth of newborns, received 200 and 400 mg/kg gallic acid doses daily by gavage method. After the birth of pups, morphological evaluations were checked. Then, in 30 postnatal days working and passive avoidance tests and anxiety test were assessed. The serum level of NFƙB was analyzed by ELISA. The working memory and fear-based memory of IUGR rats was reduced significantly compared to the controls. In addition restricted diet leads to increase in NFƙB and anxiety levels. Gallic acid was ameliorated working and fear-based memories and reduced serum level of NFƙB and anxiety in treated rats. The findings suggest that restricted diet during pregnancy can cause behavioral cognitive disorders in rats. This is likely due to increased levels of pro-apoptic cytokine such as NFƙB. The results also suggest that the neuroprotective effect of Gallic acid is likely to improve memory disorders in IUGR rat model.